Humans ; Psychological Tests ; Rhinitis, Allergic ; Rhinitis, Allergic, Perennial ; psychology

Acupuncture Points ; Acupuncture Therapy ; Adolescent ; Adult ; Aged ; Earthquakes ; Female ; Humans ; Male ; Middle Aged ; Pain Management ; Young Adult

Objective To study the oxidative damage on testis of male rats induced by micro-nano-scale SiO2. Methods Male Wistar rats were exposed to nanometer SiO2(20-40 nm) and micro-meter SiO2(1-10 ?m)by intratracheal injection once two days. The rats were killed after 5 weeks of exposure. Some indicators related to the oxidative damage in the serum and the testis were determined. Results The activity of GSH-Px and SOD in the high dose groups decreased significantly and the MDA levels increased compared to the control group;The MDA levels of nano-silicon dioxide high dose group increased in the serum. Conclusion Nano-silicon dioxide may cause lipid peroxidation in the testis with a tendency of higher toxicity than that of micro-SiO2 at the same exposed level,the detail mechanism needs further discussion.

Acetylglucosaminidase ; urine ; Adult ; Biomarkers ; urine ; Clinical Enzyme Tests ; Female ; Humans ; Insecticides ; poisoning ; Kidney Diseases ; chemically induced ; urine ; Male ; Middle Aged ; Organophosphate Poisoning ; Poisoning ; urine

Adult ; Female ; Humans ; Insecticides ; poisoning ; Male ; Middle Aged ; Organophosphate Poisoning ; Poisoning ; blood ; Serum Albumin ; analysis ; Serum Globulins ; analysis

Acute Disease ; Adult ; Female ; Humans ; Lipoprotein(a) ; blood ; Male ; Middle Aged ; Organophosphate Poisoning ; Young Adult

Adolescent ; Atrial Appendage ; Diagnostic Errors ; Female ; Humans ; Tachycardia, Ectopic Atrial ; diagnosis ; Tachycardia, Sinus ; diagnosis

Objective To detect the mutations in connexin genes in a family with hidrotic ectodermal dysplasia(HED)complicated by pseudo-ainhum.Methods Peripheral blood samples were collected from a 20-year-old patient with HED complicated by pseudo-ainhum,and from his unaffected sister.Total DNA was extracted from these samples,and PCR was performed to amplify the partial coding region of GJB2,GJB5 and GJB6 genes.Subsequently.PCR products were bidirectionally sequenced in both subjects.Results No mutation was detected in GJB5 or GJB6 gene in either subjects.Two mutations (V27I and V37I)were detected in the GJB2 gene in the patient but not in his sister.Conclusion The mutation in the GJB6 gene may be absent in patients with HED;there might be other genes involved in the pathogenesis.

Adult ; Female ; Humans ; Myocardial Infarction ; complications ; Pregnancy ; Pregnancy Complications, Cardiovascular

Drug dependence has been a severe social and health problem,which has caused serious economic losses and social disorder in China.The critical problem in drug dependence is repeated relapse even after detoxification.We have been contributed to the research of neurobiological mechanisms,clinical characteristics,and interventions of craving after withdrawal from addicting drugs.We have systemati-cally studied the change of drug seeking behavior and craving after withdrawal from cocaine,and further investigated the neural anatomic pathway,long-term neuroplasticity,and neural signal pathways which involved in the change of drug seeking behavior.According to the situation of dug abuse in China,we investigated the characteristics in the expression of incubation of craving after withdrawal from opiate.We have primarily found the neural anatomic pathways and neural plasticity mechanisms which contribute to the process.We have also demonstrated the psychological characteristics and neurobiological mechanisms of craving induced by opiate and its long-term maintenance resulting from learning and memory,chronobiology and imaging.Our findings have provided evidence for effective inventions on preventing relapse after abstinence in addicts.Abstract:SUMM ARY Drug dependence has been a severe social and health problem,which has caused serious e-conom ic losses and social d isorder in China.The critical problem in drug dependence is repeated relapse even after detoxification.W e have been contributed to the research of neurobiologicalmechanisms,clini-cal characteristics,and interventions of craving afterwithdrawal from add icting drugs.W e have systemati-cally stud ied the change of drug seeking behavior and craving afterwithdrawal from cocaine,and further investigated the neural anatom ic pathway,long-term neuroplasticity,and neural signal pathways which involved in the change of drug seeking behavior.Accord ing to the situation of dug abuse in China,we in-vestigated the characteristics in the expression of incubation of craving after withdrawal from opiate.W e have primarily found the neural anatom ic pathways and neural plasticity mechanisms which contribute to the process.W e have also demonstrated the psychological characteristics and neurobiologicalmechanisms of craving induced by opiate and its long-term maintenance resulting from learning and memory,chrono-biology and imaging.Our find ings have provided evidence for effective inventions on preventing relapse after abstinence in add icts.