Objective: To study the difference between the preventive and therapeutic effects of dexamethasone on acute lung injury models induced by lipopolysacharide(LPS) in different phases.Methods: Forty adult male Wistar rats were randomly divided into four groups:(1)control group to receive intraperitoneal NS injection(2 mL/kg).(2)LPS group to receive intraperitoneal LPS injection(5(mg/kg).)(3)one-hour group to receive intraperitoneal dexamethasone injection(2 mg/kg) one hour after LPS injection.(4)three-hour group to receive intraperitoneal dexamethasone injection(2 mg/kg) three hours after LPS injection.Then histopathology,arterial blood gases,lung permeability,wet-to-dry weight ratio and immunohistochemistry AQP1 were performed 24 hours later.Results: Dexamethasone could improve biological indexes.Lung permeability,wet-to-dry weight ratio and immunohistochemistry AQP1 were(5.73?1.37),(4.92?0.23),(19.92?6.47) in LPS group,(2.4?0.51),(4.89?0.21),(33.47?9.41) in one-hour group and(2.15?0.63),(4.57?0.14),(40.69?9.18) in three-hour group,respectively.Dates in three-hour group were prior to those of one-hour group,and there was slight but no significant difference between the two groups.Conclusion: Dexamethasone can improve lung permeability and reduce lung edema.There is no need to be treated with glucocorticoids in advance.

Although current epidemiological studies have not demonstrated that there is an association between serum cholesterol concentration and stroke, the effect of statins has been confirmed in the high-risk (mainly coronary heart disease, diabetes or hypertension) and advanced-age populations in the primary prevention studies. Statins have a good safety profile, and they do not increase the risk of intracerebral hemorrhage. The effect of statins in the secondary prevention of ischemic stroke remains to be confirmed by the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study.

Objective　To analyze the CT features and diagnostic valuation of endometriosis. Methods 　The CT features in 26 cases with endometriosis confirmed by operation and pathology were retrospectively studied. Results　The endometriosis deposited in the overly （n=16）,wall of bladder （n=2）,uterus （n=5）,and Vagina （n=3）.On CT,the lesion could appear as a round or oval or irregular,Cystic or solid or mixed mass,with unclear margin,and certain adhesion to surrounding sssstructures.There were some small cysts within the mass.On enhanced CT,the cystic margin and solid part of the mass could be enhanced. Conclusion　CT features with clinical information,it is possible to diagnosis endometriosis.

Acute Disease ; Cohort Studies ; Humans ; Leukemia ; diagnosis ; Myelodysplastic Syndromes ; diagnosis ; Prognosis

Objective To study the change of the oxygen-carried function of stored red blood cells,which was warmed in room temperature and calorstat.Methods Randomly removed from 4 ℃storage refrigerator,red blood cell suspension were put in room temperature 30 min (group N)and 37℃ calorstat 30 min (group H),and samples taken to examine electrolyte,blood gas,free Hb,ATP content,2,3-DPG content,oxygen affinity(P50).Results In two groups,blood pH value and blood Na+ did not change obviously due to heating.The content of blood K+ and free Hb increased,glucose fell,but there was no statistically significant difference.The content of ATP and 2,3-DPG in eryth-rocyte increased and P50 increased after heating (P <0.05),which increased more significantly in group H compared with group N (P<0.05).Conclusion Heating stored blood up to 37 ℃ can in-crease the oxygen-carried function of red blood cells,which contribute to improve the effectiveness of transfusion.

Tumor invasion model is an important tool to study the mechanisms of tumor mvasion and to evaluate prevention and treatment of cancer.Compared to the in vitro model,in vivo model can simulate the tumor microenvironment and tumor mvasion biological behaviour better.Morphological observation and invasion-related protein detection can be used to evaluate the animal invasion model,which are widely used in basic and clinical research now.

Objective To study the teaching effect in physical evaluation by application of item teaching method for high occupation nursing students. Methods 249 high occupation nursing students of grade 2008 from four class were divided into the experimental group and the control group randomly. 123students of the control group were taught by traditional method, 126 students of the experimental group were taught by item teaching method, that is, listing teaching emphasis, examining item and standard for evaluation, preparing the lesson for students, teaching theory for teacher, teaching medical examination in groups,simulated training, testing item. The practical operation results and various capabilities were compared between two groups. Results The practical operation results and various capabilities of the experimental group was better than the control group. Conclusions Constructing evaluation system of physical evaluation by application of item teaching method is a beneficial attempt for high occupation nursing students. It improves the students' general ability and is beneficial to the justice and fair of teaching evaluation. So it is worth popularizing.

OBJECTIVE: To investigate the efficacy and related factors of nasal surgery combined with upper air way radiofrequency ablation(RFA) for treatment of obstructive sleep apnea hypopnea syndrome (OSAHS) with chronic nasal blockage. METHOD: One hundred and three mild or moderate OSAHS patients with chronic nasal blockage were recruited, all cases had nasal surgery and upper airway RFA. All patients were evaluated by body mass index (BMI), Epworth sleep scale (ESS), snoring scale, and nocturnal polysomnography (PSG). Eighty-nine patients were reevaluated at least 6 months after surgery with the preoperative methods. RESULT: After operation, the apnea and hypopnea index (AHI) decreased from (18.67 +/- 9.48)/h to (9.22 +/- 7.18)/h; the lowest artery oxygen saturation (LSaO2) increased from (0.83 +/- 0.08) to (0.92 +/- 0.06); the Epworth sleep scale(ESS) decreased from (8.74 +/- 5.67) to (5.12 +/- 3.74); the snoring scale decreased from (7.16 +/- 2.85) to (3.56 +/- 2.26), the percentage of time with oxyhemoglobin saturation below 0.90 (CT90) decreased from (18.64 +/- 12.98) to (10.73 +/- 8.29). All of the differences were obvious (P<0.01). Success was defined as a postoperative apnea-hypopnea in dex < 10 events per hour and at least 50% less than the preoperative value. The surgical success rate was 75.3% (67/89). No major perioperative complications occurred. CONCLUSION Our findings suggest that nasal surgery combined with upper airway RFA can improve snoring and disease-specific quality of life in patients with anatomic na sal obstruction with mild or moderate OSAHS.
Adult ; Catheter Ablation ; Female ; Humans ; Male ; Middle Aged ; Nasal Septum ; surgery ; Nasal Surgical Procedures ; Sleep Apnea, Obstructive ; surgery ; Snoring ; surgery ; Turbinates ; surgery

Objective To explore the clinical curative effect of hollow screw internal fixation for the treatment of distal epiphyseal teenagers tibial fracture.Methods Thirty -nine cases of epiphyseal fractures of the distal tibia were treated in Shanghai Children′s Hospital between February 2005 and September 201 4.This study included 24 boys and 1 5 girls with the average age of 1 3.1 years (ranged 1 0.5 to 1 6.2 years old).Preoperative diagnosis was confirmed by the X -ray films or CT examination.All the cases were closed fractures and manipulative reduction all failed.Surgi-cal reduction was performed when plain radiographs showed the fracture gap of epiphysis board and articular surface were greater than 2 mm or after closed reduction.Under C -arm X -ray machine,ankle axial traction was performed initially.Anatomical reduction underwent according to the bone fracture type.The fractures were fixed with cannulated screws by percutaneous or open approach.Postoperative X -ray or CT confirmed anatomical reduction at articular sur-face and growth plate.All patients had been immobilized with short -leg cast for 4 -6 weeks.The ankle joint function and growth were evaluated by means of American Orthopaedic Foot and Ankle Society(AOFAS)Ankle Hindfoot Scale. Results All patients were followed up for 5 to 91 months with an average duration of 35 months.X -ray films showed that all fractures were bone healing.No uneven articular surface was found and there was no extremity rotation and shorte-ning deformity.Results were evaluated by AOFAS scoring system:excellent in 27 cases,good in 10 cases,and general in 2 cases.All patients were able to participate in the normal physical activities.Conclusions CT with multiplanar recon-struction is a premise to make an accurate diagnosis and to choose a reasonable approach.For failed closed reduction for adolescent distal tibial epiphyseal fractures,the cannulated screws are simple and may have a satisfactory effect.