1.Report of a case with methylmalonic acidemia.
Hong-hua LIN ; Cheng WU ; Yang DONG
Chinese Journal of Pediatrics 2008;46(7):557-558
3.Study on the changes of coagulation and fibrinolysis system in solid cancer patients and the mecha-nism of venous thromboembolism and metastasis of solid cancer
Zhao-Xia DUAN ; Lin-Hua YANG ;
Cancer Research and Clinic 2006;0(11):-
Objective To investigate the changes of coagulation and fibrinolysis systems in patients with solid cancer. Determine the mechanism of thrombosis formation in solid cancer and the the metastasis mechanism of solid cancer.Methods To measure plasma concentrations of TF,TFPI,t-PA,u-PA,PAI-1 by ELISA and test protein C activity(PC:A)by chromogenic substrate assay.Results Plasma concentrations of TF,TFPI,u-PA,PAI-1 were all higher in solid cancer patients than normal control and higher in metasta- sized team than non-metastasized team.In the dead team,u-PA and PAI-1 were higher while TFPI was low- er. t-PA was higher in cancer patients combined with venous thromboembolism while protein C activity was lower.Conclusion Disorders of coagulation and fibrinolysis system are related to the thrombosis formation in solid cancer.Coagulation and fibrinolysis factors take part in the metastasis progress of solid cancer. High concentration of u-PA and PAI-1 or low concentration of TFPI are considered to be related with poor outcome.
4.Sacral cellular schwannoma: a clinicopathologic analysis of eight cases
Jun LIN ; Daohua YANG ; Yingqi HUA ; An CHEN
Chinese Journal of Clinical and Experimental Pathology 2017;33(4):417-421
Purpose To investigate clinicopathologic fea-tures of sacral cellular schwanoma and the difference from sacral conventional schwanoma.Methods Eight cases of sacral cellular schwanoma were collected.Microscopic examination and immunohistochemistry were performed for studying the clinical feature,radiologic appearance,pathologic characteristic,immunophenotyping,differential diagnosis and postoperative prognosis.Results There were 5 females and 3 males,whose mean age was 46.4 years.The majority of patients complained of pain in sacrococcygeal region.Radiographically,there was an endosacral or endosacral and presacal mass.Histologically,cellular schwannoma was composed of spindle cells,arranged in interlacing fascicles without nuclear palisading and Verocay bodies.Antoni A and Antoni B were not seen overtly.The destruction of bone was found.Immunohistochemically,tumor cells were diffusely and strongly positive for S-100 protein and vimentin.The mean of Ki-67 index was 6%.Tumor recurrence of 4 cases occurred several years after initial surgical resection.The mean interval to recurrence was 6.5 years.Conclusion Sacral cellular schwanoma is a rare tumor.Compared with sacral conventional schwanoma,it shows different growth pattern and pathologic features.So pathological diagnosis of the tumor should be noted for clinical follow-up and treatment.
6.Asphyxiating thoracic dysplasia: a case report.
Lin YANG ; Qiu-hua LIANG ; Xiang-hang LUO
Chinese Journal of Pediatrics 2009;47(6):473-474
Asphyxia
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etiology
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Child
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Dysostoses
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complications
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Female
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Humans
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Osteochondrodysplasias
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Thorax
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abnormalities
7.A Review on the Research Progress and Prospect of the Leuconostoc mesnteroides Dextransucrase
Jin LUO ; Ya-Lin YANG ; Jian-Hua WANG ;
Microbiology 1992;0(04):-
The structure, reaction mechanism and molecular biology of Leuconostoc mesnteroides dextransucrase are reviewed.
8.A trial of applying current events to pharmacology teaching
Hua YANG ; Hao CHEN ; Qun ZHANG ; Lin-sheng LEI
Chinese Journal of Medical Education Research 2011;10(8):1003-1004
A piece of news was introduced into pharmacology course examination.Students were asked to make comments on the news based on pharmacology knowledge or principles.All points of view were summarized and given back to the students after the examination. The right way to answer the question was discussed and a consensus on the answer was reached.lt was indicated that the teaching method in the trial is helpful for improvement of students' overall analytical skills.
9.Effect of simple PKP treatment of osteoporotic thoracolumbar vertebral compression on serum leptin and bone mineral density in patients with fracture
Fanguo LIN ; Dong LIU ; Yongming SUN ; Jun HUA ; Zhaoyao YANG
The Journal of Practical Medicine 2016;32(11):1794-1796
Objective To investigate the effect of percutaneous vertebroplasty and kyphoplasty (PKP) on bone density and serum leptin in patients with osteoporotic thoracolumbar compression fractures. Methods One hundred and two patients with osteoporotic thoracolumbar vertebral compression fractures and 100 cases of healthy control were treated with PKP surgery. The serum leptin and adiponectin, and the bone mineral density of the lumbar spine were determined. Results patients Levels of the serum leptin and adiponectin in patients with osteoporotic thoracolumbar vertebral compression fracture were significantly higher than those with non osteoporotic fracture patients (P < 0.05). One month post-PVP, the levels of serum leptin and adiponectin in the two groups were significantly decreased (P < 0.05). postoperative group of The lumbar bone density at 1 month post-operation was is significantly higher than that before operation in each group (P < 0.05, respectively), with no significant difference between the two groups. The levels of serum leptin and adiponectin were negatively correlated with the bone mineral density (BMD) (P < 0.05). Conclusions tLevels of serum adiponectin and leptin were both increased in osteoporotic or non bone osteoporosis thoracolumbar vertebral compressor fractures. The percutaneous vertebroplasty forming operation could effectively reduce the serum level of leptin and adiponectin, and improve the bone mineral density of the lumbar vertebrae.
10.Study on changes of IL-6, IL-10 and TNF-αafter cholecystectomy
Xianyi ZHANG ; Hua YANG ; Shenglin LONG ; Hao LIN ; Yingqiang CHEN
Chinese Journal of Biochemical Pharmaceutics 2015;(8):89-91
Objective To investigate the changes of IL-6, IL-10 and TNF-αafter cholecystectomy.Methods 46 cases with cholecystolithiasis were selected and divided into 2 groups.23 in control group were treated with open cholecystectomy, experimental group were treated with laparoscopic cholecystectomy.The levels of IL-6, TNF-α, IL-10 and CD4 +/CD8 +T were compared in the two groups pre-and post-treatment.ResuIts Compared with pre-treatment, two groups of patients with IL-10, TNF-α, IL-6 and CD4 +T and CD4 +/CD8 +T increased (P<0.05), compared with control group, experimental group IL-10, TNF-α, IL-6, CD4 +/CD8 +T levels were higher (P<0.05).ConcIusion Laparoscopic cholecystectomy can significantly reduce the IL-6, TNF-αand IL-10 levels, reduce the body′s stress response to surgery, and reduce blood flow, shorten the operation time.