Diabetic macular edema (DME) is a leading cause of vision loss in diabetic patients.It is very important to correctly select a treating approach for DME.At present,the treating methods of DME include retinal laser photocoagulation,application of the glucocorticoid,intravitreous injection of anti-vascular endothelial growth factor (VEGF) drugs,administration of inhibitor of protein kinase C,vitrectomy and combined treatment etc.However,each method has its advantage and disadvantage.Retinal photocoagulation,vitrectomy,intravitreous injection and drug delivery system implantation are invasive treatment methods,and they can not rescue damaged retinal photoreceptors.Therefore,it is recommended that DME should be early diagnosed and effective treatment.The research status at home and abroad and future development trends of DME treatment were summarized.

Altitude Sickness ; diagnosis ; Humans ; Occupational Diseases ; diagnosis ; Reference Standards

Objective To evaluate the feasibility and safety of hand-assisted laparoscopic one-stage operation for colorectal cancer with single hepatic metastasis.Methods The clinical data of 6 patients of colorectal cancer with single hepatic metastasis treated with hand-assisted laparoscopic one-stage operation between Aug 2009 and Mar 2010 were analyzed retrospectively.Result Procedures were completed successfully in all cases and there was no conversion to open surgery.The mean operation time was (183 ±45) min,the mean blood loss in operation was (165 ±70) ml,the mean time to intestinal function recovery was (69.4 ± 10.5) h,and the average length of stay was (9.5 ±3.2) d.There was no major intraoperative or postoperative complications.All the patients received chemotherapy and up to 30 months follow-up found good condition in all but one dying of widespread intraabdominal tumor metastasis.Conclusions Handassisted laparoscopic one-stage operation for colorectal cancer with hepatic metastasis is feasible and safe.

Animals ; Cytokines ; blood ; Humans ; Peripheral Vascular Diseases ; etiology ; physiopathology ; Rabbits ; Vibration ; adverse effects

Objective To investigate the changs of serum and urine vascular endothelial growth factor(VEGF) in children with steroid-sensitive nephrotic syndrome(SSNS) at their active and remission stage.Methods Serum and morning urine levels of VEGF were assayed by Liquichip in 30 patients with SSNS at the active and remission stage and 30 normal age-and sex-matched controls.Results Serum levels of VEGF in patients at the active stage [(186.62?106.21) ng/L] were significantly higher those that at the remission stage [(118.75?73.08) ng/L] and than those in control group [(108.64?54.75) ng/L](P0.05).Morning urine levels of VEGF in patients at the active stage [(201.66?100.46) ng/L] were significantly higher than those at the remission stage [(116.35?55.99) ng/L] and than those in control group [(99.94?42.07) ng/L](P0.05).Conclusions Serum and morning urine levels of VEGF are significantly elevated in patients with SSNS,however they are significantly lower after the treatment of steroid.There is no obvious difference between the patients at the remission stage and healthy controls.VEGF involves pathogenetically and physiologically in SSNS during its onset and growth.

ObjectiveTo investigate the effect of nickel-titanium(Ni-Ti) shape memory alloy embracing internal fixer on oblique or spiral fracture.Methods23 cases with spiral or oblique fracture accepted internal fixation with Ni-Ti shape memory alloy embracing.The time of bone healing,articular function,the appearance and function of the wound extremity were evaluated after 9～34 months follow-up.ResultsAll fractures healed in 4～16 weeks after operation.None infection,nonunion,embracing emersion or break had been found. The fine rate was 91.3%.ConclusionThe effect of Ni-Ti shape memory alloy embracing internal fixer on long spiral or long oblique fracture is satisfactory.

Objective: To investigate the anti-inflammatory and analgesic effective fractions from Cayratia japonica. Methods: The acute inflammatory models, such as xylene-induced ear edema, egg white-induced paw edema, and the chronic inflammatory model granuloma induced by cotton pellet implantation, were used in researching the inflammatory effects of the different fractions from C. japonica by ig administration. Meanwhile, the analgesic effects of the different fractions from C. japonica were observed by hot plate and acetic acid writhing test. Results: Compared with the model group, high-and low-dose water fraction and water extract could significantly inhibit ear edema in mice (P<0.05, 0.01) and paw edema in rats (P<0.05, 0.01). Also, water fraction and water extract decreased the granuloma of rats (P<0.01). Moreover, after the treatment with high-and low-dose petroleum ether fraction and water extract, the pain threshold with hot plate method was significantly prolonged (P<0.05, 0.01) compared with the model group and the data before the drugs administration. The writhing number was reduced after administration (P<0.01) compared to the model group. Conclusion: The anti-inflammatory effect of C. japonica mainly locates in the water fraction, and the analgesic effect is mainly the petroleum ether fraction.

Objective: To investigate the anti-inflammatory and analgesic effects of Polygonum orientale extract. Methods: The acute inflammatory models such as xylene-induced ear edema and egg white-induced paw edema and the chronic inflammatory model granuloma induced by cotton pellet implantation were used in researching the inflammatory effects of water and alcohol extract from P. orientale (POWE and POAE) by ig administration. Meanwhile, the analgesic effects of POWE and POAE were observed by hot plate and acetic acid writhing test. Results: Compared with the model group, high- and low-dose (7.5 and 3.75 g/kg) POWE and POAE could significantly inhibit ear edema in mice (P < 0.01) and paw edema in rats (P < 0.05, 0.01). Also, POWE and POAE decreased the granuloma of rats (P < 0.01). Moreover, after treatment with high- and low-dose POWE and POAE, the pain threshold with hot plate method was significantly prolonged (P < 0.01) compared with the model group. The writhing number was reduced after administration (P < 0.01) compared to the model group. However, there were substantial variations between the POAE groups and the same dose of POWE in high and low concentration (P < 0.05, 0.01). Conclusion: P. orientale extract possesses the anti-inflammatory and analgesic effect, and POWE has better effect than POAE.

Accidents, Occupational ; Adult ; Female ; Hexanes ; poisoning ; Humans ; Male ; Occupational Diseases ; chemically induced ; diagnosis ; Shoes