Antineoplastic Agents ; therapeutic use ; Benzamides ; Chemotherapy, Adjuvant ; Gastrointestinal Neoplasms ; drug therapy ; metabolism ; pathology ; surgery ; Gastrointestinal Stromal Tumors ; drug therapy ; metabolism ; pathology ; surgery ; Humans ; Imatinib Mesylate ; Indoles ; therapeutic use ; Mutation ; Neoplasm Staging ; Piperazines ; therapeutic use ; Proto-Oncogene Proteins c-kit ; metabolism ; Pyrimidines ; therapeutic use ; Pyrroles ; therapeutic use ; Receptor, Epidermal Growth Factor ; genetics ; metabolism ; Vascular Endothelial Growth Factor A ; metabolism

Hepatocellular carcinoma (HCC) is one of the most common malignant tumor with increasing incidence worldwid.Most of patients with HCC are diagnosed at a late stage.Threrfore,the prognosis of HCC patients is generally poor with a 5-year survival rate of 20% if withoutoperration. Screening strategies including α-fetoprotein (AFP) and ultrasound every 6 months in patients with liver cirrhosis,the major risk factor for HCC development, have been recommended to detect HCC at earlier stages amenable to effective treatment strateges.AFP, however,is a marker with poor sensitivity and specificity and the ultrasound is highly dependent on the operator's experience.Apart from AFP, lens culinaris agglutinin-reactive AFP and des-gamma carbexyprothrombin and several other biomarkers(e.g., glypican-3,human hepatocyte growth factor,and insulin-like growth factor) have been proposed as markers for HCC detection.In addition,with recently employed techniques,such as gene-expressing microarrays and proteomics,it is to be expected that new HCC-specific markers will become available in the near future.For all such proposed markers,however,the clinical usefulness has to be carefully evaluated and validated.

Objective:We try to examine the hypothesis that perceptual reversal is function of frontoparietal cortex. Methods:We employed block design in functional MRI, extracted event signal of endogenous reversal of Necker cube and compared with that of exogenous reversal. Results:Functional MRI revealed that spatial varieties were significant in bilateral superior and middle frontal lobe. Conclusion:Perceptual reversal may be the function of frontal cortex.

The latest advances on target therapies of cancer were presented on the 44th Annual Meeting of American Society of Clinical Oncology(ASCO)in 2008.One of the most important results was the outstanding efficacy of Cetuximab in Metastatic Colorectal Cancer fIncao patients with k-ras"wild-type".Besides,detection of k-ras statuswouldmakeitpossibleforthetailoredtargettherapy of mCRC.Itwasestimatedthat k-ras gene status would become a predictive molecular marker for Cetuximab treatment in mCRC.

The opening rate, information update and menu of official WeChat in 11 Hangzhou municipal public hospitals were analyzed in order to understand their running, which showed that of the 11 public hospitals that opened their official WeChat,36. 36% opened their service account and 63. 64% opened their subscription ac-count. The information update frequency of WeChat varied and the online service function needed to be further deepened. Suggestions were put forward for the WeChat running in hospitals, such as normalizing its information push, deepening its online service, diversifying its communication between physicians and patients, and intensifying its popularization.

Objective To explore the efficacy of zolpidem in improvement of sleep quality of patients received methadone maintenance treatment (MMT).Methods 80 cases of MMT with insomnia were randomly divided into the study group (administered with zolpidem)and the control group (administered with placebo), 40 cases in each group.Pittsburgh sleep quality index (PSQI)and treatment emergent symptoms scale (TESS)were assessed before treatment and at the weekend of 4th,8th after treatment.Results The scores of PSQI in the study group were much lower than those in the control group (t =-2.517,P =0.014;t =-3.611,P =0.000),while the effective rate in the study group was significantly higher than that in the control group (χ2 =4.949,P =0.026). Conclusion Zolpidem could improve the sleep quality of patients with MMT.

Objective To investigate relation between atrial enlargement and pathogenesis of atrial tach yarrhythmia.Methods 786 patients were observed with atrial tachyarrhythmia through 24-hour electrocardiographic monitoring,echocardiographic was used to analysis atrial enlargement.Results The patient with left atrial enlargement in atrial tachyarrhythmia was more than those with right atrial enlargement(73.82%vs 21.25%,P＜0,01).Conclusions Atrial enlargement,especially left atrial enlargement,was the one of most important pathogeny in atrial tachyarrhythmia.The enhancement of pressure and muscle tension in atrial were the major factors of electronicphysiobgy disorganization,and the left atrial was the leading position in patients with electronicphysiology abnormity.

Objective To explore the relation between single umbilical artery with other malformations and pregnancy outcome,and to provide evidence for pregnancy counseling and diagnosis.Methods The outcomes of 92 fetuses with single umbilical artery diagnosed and delivered in Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University from September 2007 to July 2009 were followed up and retrospectively analyzed with Chi-square test.Results Among 25 292 pregnant women,92 cases were finally diagnosed as single umbilical artery giving the incidence of 0.36％,among which 57.6％ (53/92) of newborns survived without malformations,15.2％(14/92) survived with malformations and 27.2％ (25/92) died during perinatal period.There were 36 fetuses (39.1％,36/92) with single umbilical artery complicated with other malformations,among which 29 had single malformation (80.6 ％ ),and seven ( 19.4 ％ ) had multiple malformations.The incidence of heart defects was the highest among the complicated malformations,and then followed by central nervous system,digestive system,motor system and urinary system.Thirty-three fetuses with single umbilical artery accepted karyotype analysis.Chromosome abnormality was diagnosed in three subjects (9.1％,3/33).Twenty-three fetus (25.0％,23/92) associated with small for gestational age,and among which 18 fetuses (78.3％,18/23) died with a higher mortality than that (4.0％,24/597) of small for gestational age patients without single umbilical artery (x2=181.71,P＜0.01).Conclusions Single umbilical artery is likely to be complicated with congenital anomalies.After single umbilical artery was diagnosed by routine ultrasound,fetal ultrasonography,echocardiography and amniocentesis for karyotype analysis is suggested.Fetal growth restriction is an important indicator of fetal adverse outcomes.

Dr.WU Liang-cun applys constitution doctrine of TCM in treating geriatric oncology patients.According to the classification of constitutions and the features of geriatric oncology’s pathogenesis,Dr.WU Liang-cun advocates the principle of comprehensive treatment and stage treatment.There are different rating in different fuzhenquxie period basis on the patient’s condition of zhen-xie and xu-shi.Dr.WU Liang-cun always pays attention to applying wenshen pharmacy in his prescription.

OBJECTIVE To investigate the usage of antibiotics for improving the management and proper clinical utilization. METHODS The data of 781 inpatients had been analyzed by field survey in our hospital in July 27,2005.The data were analyzed by computer. RESULTS The rate of antibiotic usage was 56.98%,and the rate of preventive antibiotic usage was 20.74%.Cephalosporins were the first,quinolones were the next and then penicillins in the antibiotics usage.Only 33.57% infectious patients were made bacteria culture and antibiotics drug sensitive test.Most antibiotics were used according to clinical experience. CONCLUSIONS Most of the doctors can use antibiotics properly.The strengthening control and rational antibiotics usage in prevention are the key means to decrease the numbers of irrational application.