Objective To explore the individual psychological intervention on the perioperative psychological state of liver transplantation patients.Methods Ninety - six liver transplantation patients in June 2008 to June 2011 were randomly divided into observation group and control group,each group 48 cases.Control group received routine care,the observation group received individual psychological nursing on the basis of routine care.Then patients' perioperative psychological status,surgery complications,length of hospital stay,patients' satisfaction in two groups were observed and compared.Results Before the operation,the SAS,SDS scores in two growps,there were no.statis tically significant differences ( P ＞ 0.05 ) ; Three days laror,the SAS,SDS scores in two groups,there were statis tically significant diffrernces ( P ＜ 0.05 ) ; Ten days later,the postoperative SAS score of observation group was ( 38.82 ± 11.13 ) significantly lower than (43.29 ± 13.16 ) of control group ( t =12.602,P ＜ 0.05 ).The average score of SDS in observation group was ( 36.75 ± 12.20) lower than (47.76 ± 15.82 ) in control group ( t =18.931,P ＜ 0.05 ).Surgery complications and length of hospital stay in observation group were significantly lower than that of control group ( t =16.201,x2 =6.697 ; P ＜ 0.05 ) and patients' satisfaction in observation group was significantly higher than that of control group[ (94.62 ± 17.52) vs (76.69 ± 19.14) ; t =29.641,P ＜ 0.05 ].Conclusions Psychological intervention can decrease the perioperative anxiety and depression of liver transplantation patients,and effectively promote postoperative rehabilitation and it is worth clinical spreading.

In addition to the ribosome, aminoacyl-tRNA, and mRNA, translation factors are also necessary for protein synthesis.The eukaryotic translation initiation factor 5 A (eIF5A) is essential for cell viability and well conserved in all three domains during evolution.It is the only protein in eukaryotic cells that contains the unusual amino acid hypusine and the unique post-translational modification of eIF5A is strictly required for its function.eIF5A was identified in 1978 for the first time and was thought to stimulate the formation of the first peptide bond during translation initiation phase.Its involvement in the translation of polyproline-containing protein was not uncovered until 2013.With the research of over 40 years, our understanding of eIF5A function has changed dramatically.Recent ribosome profile data demonstrate that eIF5A works more generally at many ribosome stalled sites, and not limited to polyproline motif.It also enhances translation termination by facilitating peptide release.Moreover, eIF5A also indirectly regulates various cell life activities by controlling the translation of certain proteins.In this review, we provide a summary of the post-translational modification, the regulating effects during protein synthesis and autophagy as well as the relationship between eIF5A and human diseases, and explore the evolutionary conservation of eIF5A by comparing with the bacterial and arehaeal orthologs, so as to provide a theoretical basis for the research in related fields.