In recent years,considerable progress has been made in the treatment of multiple myeloma(MM).However,despite the current improved prognosis of this malignancy,it always ends in relapse and therefore new therapeutic approaches are urgently needed to overcome it.The chimeric antigen receptor(CAR)-T cells targeting B cell maturation antigen(BCMA),cluster of differentiation 19(CD19),cluster of differentiation 38(CD38) and kappa light chains have been evaluated,and have achieved remarkable results in clinical trials.However,even when MM is treated with CAR-T cell therapy,most patients eventually relapse,which is the greatest limitation of this therapy.This paperreviewedthe research progress,limitations and optimization of CAR-T cell immunotherapy in the treatment of MM.

Gefitinib and erlotinib are the first generation of targeted therapeutic agents approved for the treatment of advanced non-small cell lung cancer. Despite a dramatic initial response, most patients subsequently and ultimately become resistant to the drugs. Recent studies have proposed various mechanisms of such resistance, some of which related to a second mutation in epidermal growth factor receptor, aberrant activation of other tyrosine kinase receptors, bypassing signal pathways and constitutive activation of downstream signal molecules. Other researches also associated the drug resistance to internalization of epidermal growth factor receptor and changes in tumor microenvironment. Furture studies need to focus on overcoming or reversing resistance to the drugs and developing new targeted therapeutic agents.

Objective To interview the work feelings of the Middle youth patients with peritoneal dialysis. Methods Using the purposive sampling method, 11 patients were interviewed, and analyzed the content of the interview. After the interview, data were transcribed and extracted the keywords. Results Eight keywords were extracted, the patients had four positive feelings:self-perceived burden relived;more social support; more glad, negative feelings relived; peritoneal dialysis could be sure. 4 negative themes were extracted:tedious;had economic pressure;lack of self-realization;could not take the family burden. Conclusions Work can improve the living conditions of middle youth patients with peritoneal dialysis. More patients should be encouraged to return to work.

Objective To establish a HPLC method to determine the antiseptics in compound dexamethasone acetate cream and evaluate the usage rationality of antimicrobial preservatives. Methods The content of ethyl hydroxybenzoate was calculated by external standard with HPLC.The effectiveness of antimicrobial preservatives was measured according to the preservative effectiveness test in ChP(2015edition) by inoculating 5 kinds of test microorganisms including Pseudomonas aeruginosa,Escherichia coli,Staphylococcusaureus,Candida albicans and Aspergillusniger.Results The linear ranges of ethyl hydroxybenzoate was 6.63-132.6 μg/mL ( r =0.999 7 ) .The average recoveries was 99.2%.The samples from different batche had different antimicrobial effectiveness due to the content of ethyl hydroxybenzoate.Conclusion The described method can be used in the determination of the preservatives of ethyl hydroxybenzoate in compound dexamethasone acetate cream.At present the use of antibacterial agent is arbitrary, it is necessary to strengthen research and supervision.

A systematic comparative study ou the morphology and histology of the rhizomes of polygonatum including "Huangjing" and "Yuzhu" currently available on the Chinese market werepresented. The differences between this two types of herbal medicines were given.

Objective To approach the effects of decoction changed from Didangtang and Xiaoxianxiongtang Modified Formula on mucoprotein in stratum medium and the III-type collagen level of serum in experimental rats with fibrosis disease in lung interstitial tissue. Methods 40 male Wistar rats were randomly divided into 4 groups, that is pseudo-operation group, model control group, traditional Chinese drug group (TCD) and western medicine group (WM). Every group has 10 rats. Acid hydroc bleocin was dripped disposably into trachea of every group rats except pseudo-operation group, and Sodium Chloride with same volume as Acid hydroc bleocin was dripped disposably into trachea of pseudo-operation group. 24 hours after operation, the rats of TCD was lavaged with Decoction changed from Didangtang and Xiaoxianxiongtang Modified Formula, and the rats of WM was lavaged with Prednisone physiological saline solution. The rats of pseudo-operation group and model control group was lavaged with Sodium Chloride of same volume as TCD and WM. 28 days after operation, the rats was executed. And contents of mucoprotein in stratum medium of and the III-type collagen serum was detected. Results Didangtang and Xiaoxianxiongtang Modified Formula could decrease contents of mucoprotein in stratum medium of and the III-type collagen in serum of experimental rats, and extenuate fibro-accrementition in lung interstitial tissue. Conclusion Didangtang and Xiaoxianxiongtang Modified Formula has the function of treating fibrosis disease in lung interstitial tissue probably by decreasing contents of extracellular matrix in experimental rats with fibrosis disease in lung interstitial tissue.

The material of this paper comes from a real consolidation case of the radiography department of a hospital, which succeeds in sharing several automatic processors through layer 3 switching.

Objective To investigate the free radical scavenging effects and antioxidation activity of squid(Dosidicus eschrichitii Steenstrup) skin gelatin hydrolysate.Methods The free radical scavenging effects of the hydrolysate on superoxide and hydroxyl free radicals were assessed by chemiluminescence analysis method.The activity of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px) and content of malondialdehyde(MDA),hydroxyprolyne(Hyp) in blood serum and skin tissue in galactose treated mice were analyzed after 42 days of hydrolysate feeding.Results and Conclusion The fraction with relative molecule weight less than 2000 D of the hydrolysate had the highest free radical scavenging effects on superoxide and hydroxyl free radicals,and the activities of SOD,GSH-Px were enhanced,the quantity of MDA in blood serum and skin tissue of the mice was decreased and the quantity of Hyp in skin tissue of mice was increased after the hydrolysate administration.

Objective To investigate the significance of MMP-3 and IL-15 in the patients with ankylosing spondylitis (AS).Methods The serum levels of MMP-3,IL-15,TNF-? and CRP of 45 patients with AS and 31 healthy controls were tested by sandwich ELISA.The results between the 2 groups were compared each other.Results Significantly increased serum levels of MMP-3,TNF-? and CRP were found in AS patients as compared to those in healthy controls(P

Objective:To explore influence of large dose atorvastatin therapy on ventricular remodeling in rats after myocardial infarction.Methods:A total of 48 male SD rats were randomly and equally divided into myocardial in-farction (MI)control group (received deionized water gavage),routine dose group (received atorvastatin 20mg/kg gavage four weeks before and after MI model was established)and large dose group (received atorvastatin 80mg/kg, in the same way as routine dose group).On two days after MI,hematoxylin eosin (HE)staining was used to detect pathological changes of myocardial tissue;four weeks later,Masson staining was used to evaluate myocardial fibrosis while echocardiography was used to assess cardiac chamber size and heart function,the results were compared among three groups.Results:Pathologic change:On two days after MI,color of stained myocardial tissue was uneven, muscular fiber arranged in turbulence,there were partial dissolved muscle focus and blockbuster collagenous fiber in MI control group;color of stained myocardial tissue was lack of even,arrangement of muscular fiber was irregular, there were less dissolved muscle focus and collagenous fiber in routine dose group;color of stained myocardial tissue was slightly uneven,muscular fiber still arranged in rules and there was very few dissolved muscle focus and still more survived myocardium in infarct area,and small amount of collagen fibrosis was found in myocardial cell clear-ance after four weeks in large dose group.Change of left ventricular structure and function:Compared with MI con-trol group and routine dose group,the left ventricular end-diastolic dimension [LVEDd,(7.68±0.54)ml vs.(7.06 ±0.68)ml vs.(6.37 ± 0.40)ml] significantly reduced in large dose group, left ventricular ejection fraction [LVEF,(33.0±7.9)% vs.(39.3±2.8)% vs. (48.7%±9.1)%]significantly rose (P <0.05,or <0.01);but those indexes no significant difference between MI control group and routine dose group (P =0.059,0.146 respec-tively).Conclusion:Large dose atorvastatin may significantly relieve ventricular remodeling after infarction.