Background: Tunnel thread-drawing therapy is an effective treatment for complex anal fistula, and this therapy may be used for horseshoe-shaped low-position perianal abscess. Objective: To analyze the therapeutic effects of tunnel thread-drawing therapy in treatment of horseshoe-shaped low-position perianal abscess. Design, setting, participants and interventions: A total of 68 patients with horseshoe-shaped low-position perianal abscess were from Department of Anorectal Surgery, Shanghai Tianshan Traditional Chinese Medicine Hospital, and were randomly divided into treatment group and control group. There were 34 cases in each group. The patients in the treatment group received thread-drawing therapy and the patients in the control group received multiple incisions and drainage. Main outcome measures: Lasting time of postoperative pain, healing time of incision, average area of the wound scar, anal function and postoperative recurrence were observed in the two groups. Late postoperative follow-up was from half a year to three years. Results: The lasting time of postoperative pain and healing time of incision in the treatment group were shortened as compared with those in the control group (P<0.01). There was no significant difference in postoperative recurrence rate between the two groups (P>0.05). Conclusion: There is a significant curative effect of tunnel thread-drawing therapy in treatment of horseshoe-shaped low-position perianal abscess.

Objective To investigate preoperative infection prevalence indicators of orthopedic emergency surgery patients,to analyze infection index distribution and prevalence of orthopedic emergency surgery patients before operation.Methods Enzyme-linked immunosorbent assay(ELISA) was used to detect the hepatitis A virus antibody (anti-HAV),hepatitis C virus antibody (anti-HCV),human immunodeficiency virus (1/2)-type antibody (anti-HIV1/ 2) and Treponema pallidum antibodies (TPAb)in 4 381 cases received orthopedic emergency surgery.Results The positive rates of hepatitis C and syphilis antibody in male patients were 0.228％,0.821％,those in female patients were 0.366％,0.686％,the differences were statistically significant (x2 =3.543,3.631,all P ＜ 0.05).The HAV antibody positive rates in young group,middle age group and elderly group were 0.000％,0.329％ and 0.101％ ;the positive rates of hepatitis C antibody were 0.107％,0.591％ and 0.203％ ;the positive rates of syphilis antibody were 0.160％,0.854％ and 1.722％ ;HIV antibody positive rates were 0.000％,0.131％ and 0.000％.,The positive rates of hepatitis C and syphilis antibody between the young group and elderly group had statistically significant differences (x2 =3.654,5.743,all P ＜ 0.05).The positive rates of hepatitis C antibodies,syphihs,HIV (1/2) antibody,hepatitis A antibody between the middle-age group and the young group had statistically significant differences (x2 =3.543,3.854,5.432,3.432,all P ＜ 0.05).The positive rates of hepatitis C antibodies,syphilis,HIV (1/2) antibody,hepatitis A antibody between the elderly group and the middle-age group had statistically significant differences(x2 =3.546,3.6431,3.564,3.433,all P＜0.05).Conclusion In 4381 patients,the indicators are not zero,suggest that preoperative infectious diseases are likely to be infected.For patients before surgery to make hepatitis A,hepatitis C,human immunodeficiency virus,syphilis antibody detection has a positive meaning.

Objective To investigate the effect of community-based rehabilitation on psychotic patients.Methods84 severe psychotic patients were treated with multidisciplinary community-based rehabilitation including specific drugs, psychological treatment, medical workers, family care, and etc. The implementation rate of taking medicine, improvement rate of disease, working ability of the patients before and after treatment were compared.ResultsAfter treatment, the implementation rate of taking medicine increased from 33.33% to 89.29% ( P<0.01), improvement rate of disease increased from 19.05% to 80.95% ( P<0.01), the working ability increased from 10.71% to 30.95% ( P<0.01), blocked rate decreased from 15.48% to 5.95%, the rate of causing trouble decreased from 2.38% to 0.ConclusionThe community-based rehabilitation can significantly improve the health status and quality of life for the psychotic patients and decrease the accident rate.

Bacterial Infections ; epidemiology ; etiology ; Cerebral Hemorrhage ; diagnosis ; etiology ; therapy ; Craniocerebral Trauma ; diagnosis ; etiology ; therapy ; Female ; Fetal Membranes, Premature Rupture ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases ; diagnosis ; etiology ; therapy ; Pregnancy ; Risk Factors ; Tomography, X-Ray Computed

ObjectiveTo investigate the effects of recombinant human erythropoietin (rhEPO) on the apoptosis of human mesenchymal stem cells induced by H2O2 and related cell signaling pathways.Methods After being cultured in vitro, human MSCs were treated with rhEPO.Phosphorylation of ERK1/2,p38 MAPK and PI3K/Akt was detected by using Western blotting.One h after pretreatment with1U/ml rhEPO,cells were cultured in the presence of1mmol/L H2O2 for1h.Cell morphology was observed under the inverted microscopy.Cell apoptosis was determined by using flow cytometry,migration assay was performed in Transwell chambers,and adhesion assay was performed by plastic dishes.ResultsRhEPO could increase phosphorylation of PI3K/Akt pathway in human MSCs,but reduce phosphorylation of p38MAPK.RhEPO had no obvious effect on ERK1/2 pathway and total proteins of Akt and p38MAPK.RhEPO could decrease apoptosis of human MSCs induced by H2O2 (P＜0.01) and the inhibitory effect was abrogated by Ly294002 but not anisomysin.Conclusion RhEPO could protect MSCs from apoptosis. Activation of PI3K/Akt pathway was involved in the effect of rhEPO on apoptosis.

Ethical Anthropology is a very important discipline that we should pay great attention to.It should make great contribution to the regulation of basic health policy for poor,minority nations and to the development of regional medicine in developing and third-world countries as well.Also,Ethical Anthropology will have great influenve on modern health reform and current health policy in China.

OBJECTIVE:To investigate the effect of extract of Ginkgo biloba(EGb) on levels of Endothelin-1(ET-1) and transforming growth factor ?1(TGF-?1) in renal tissue of diabetic rats.METHODS:Twenty-four male Sprague-Dawley rats were randomly divided into three groups:normal control group,diabetic model group and EGb-treated group.The levels of blood glucose,insulin,total cholesterol(TC),total triglycerides(TG),creatinine clearance(Ccr),urinary albumin excretion(UAE),and urinary ?2-MG were measured after 8-week corresponding treatment.Expression of SET-1,UET-1,and RET-1 was examined by radioimmunoassay technique.Expression of STGF-?1 and UTGF-?1 in serum and urine was examined by enzyme linked immunosorbent assay(ELISA).RESULTS:The concentrations of blood glucose,blood insulin,TC and TG increased significantly in diabetic group,which were down-regulated by EGb.Levels of ET-1 and TGF-?1.in both blood and urine and the ET-1 level in renal tissues were significantly higher in diabetic model group than in normal control group(P

We are constantly reminded to take care of ourselves. We need a healthy and balanced diet, with regular exercises, and good quality rest. However, research has shown that social connectedness also plays an essential and critical function to our physical and mental well-being. Many studies have shown that lack of social connection is a predictor of social isolation, resulting in greater detriment to health. Strong social connectedness is associated with increased longevity, strengthening of ones’ immune system, faster recovery from disease and, hence, a lengthening of one’s life. Studies have also shown that people who feel more connected to others in relationships tend to generate a positive feedback loop in communicating and maintaining healthy social and emotional well-being with others in the family, workplace and community. This decreases the propensity to antisocial behaviour, isolation behaviour or poor mental health. Individuals with strong connectedness were observed to have lower rates of anxiety and depression; and higher self-esteem and were more empathic towards self and others, resulting in better emotional and psychological well-being. Social connectedness is a broad topic and can be reviewed from various perspectives. This article will review the concept from a psychological perspective of self, exploring the importance of practicing compassion intervention in social connectedness and self-care.

Objective To observe the effect of panax notoginseng saponins (PNS) pretreatment on the expression of wnt4 protein in renal ischemia reperfusion injury in rats. Methods Seventy-two male SD rats were randomly averaged into control group (CON group), renal ischemia-reperfusion group (IR group) and PNS group. Rats in CON group were removed the right kidneys, and the left kidneys were exposed for 30 minutes, and then the incisions were closed. Rats of IR group were removed the right kidneys, and the left renal artery were clamped for 30 minutes, and then the incisions were closed. Rats in PNS group were injected PNS (150 mg/kg) via tail vein for 3 days before experiment, and the rest steps were the same with IR group. After 24 h, 48 h and 72 h reperfusion, 8 rats in each group were killed, and blood and kidney samples were collected to examine the serum creatinine (Scr) and blood urea nitrogen (BUN). The left renal tissues were stained with HE. Pathological changes were observed under light microscopy. The score of renal tubular injury was evaluated. Immunohistochemistry was performed to detecte the expression of wnt4 in kidney tissue. The expression of wnt4 was detected by Western blot assay. Results There was significant renal injury in IR group. The renal tubular injury score, Scr and BUN reached the peak levels of injury at 24 h, which were then decreased gradually, but at 72 h still significantly higher than those of CON group (P<0.05). The renal tubular injury score, Scr and BUN values at different time points were significantly lower in PNS group than those of IR group (P<0.05). The results of wnt4 immunohistochemistry and Western blot assay were consistent, which showed that the expression of wnt4 peaked at 24 h in IR group and PNS group, but the expression levels were significantly higher in PNS group than those of IR group at each time point (P<0.05). Conclusion PNS could protect kidney from ischemia-reperfusion injury, which may be related to the enhanced expression of wnt4 protein.

More and more linear servo systems have been used in servo applications. Direct drive technology can greatly increase the bandwidth and the tracking accuracy. A position servo-system based on linear voice-coil motor was designed for one linear oscillation movement application. Besides the conventional position, speed and current control loops, the speed and acceleration feed-forward control of command position signal were also used. The experimental test proved the correctness of the design, and the system can track the given periodic sinnsoid position command signal of 15Hz with high accuracy. The linear voice-coil motor is very suitable for short stroke position tracking application with high dynamic response.