This paper describes the principle and circuit design of a new hemorrhoids therapy apparatus applied in anorectal surgery,Through clinical,practices in more than two years,it is proved to be an ideal instrument that can replace a variety of traditional hemorrhoids therapy methods.

Objective: To evaluate the outcomes of current studies regarding the beneficial effects of infant massage therapy. Method: Firstly, some common knowledge related to massage is provided. Subsequently, research-based evidence on massage effects in neonatal unit has been examined, particularly on premature babies and newborns with jaundice. Result and Conclusion: the practice of massage therapy promotes the development of preterm babies and the treatment of neonates with jaundice generally safe, however the methodology employed in reviewed studies is of certain limitations, such as a lack of RCT with large sample size, inadequate follow-up period.

Humans ; Laparoscopy

The purpose of this study is to investagate the meaning of systolic time intervals (STI) in evaluating cardiac functional condition of athletes.1. STI and step test were examined on 13 sprinters, 8 jumpers, 5 throwers and 5 distance runners during early, middle and the last phases in summer training season.No significant changes of the left ventricular ejection time (LVET), the pre-ejection period (PEP) and PEP/LVET ratio were found from examinations on athletes in the three different phases.The cases were divided into two groups of PEP/LVET ratio increased more than 0.05 (N=8) and PEP/LVET ratio decreased more than 0.05 (N=10) by the different of PEP/LVET ratio between linked phases examinations. Athough two of PEP/LVET ratio of each group were different evidently (P

Objective To evaluate the clinical value of fetal holoprosencephaly complicated with face malformation by two-dimensional(2D) and three-dimensional(3D) ultrasonography.Methods Fetal faces and brains were examined regularly with 3D ultrasonography when they were suspected abnormal with 2D ultrasonography and compaired the diagnoses with postnatal or induced delivery results.Results 11 cases of holoprosencephaly complicated with face malformation were diagnosed using 2D and 3D ultrasonography.Among these cases,there were 4 with single median mostril,2 with proboscis,2 with cheiloschisis,2 with multipte face malformation,1 with arhinia.They were all comfirmed by postnatal or induced delivery.Conclusions 3D ultrasonography provides visualized,three-dimensional,more precise and clearly fetal structure imagine.It has important supplement to 2D ultrasonography.2D ultrasonography combined with 3D ultrasonography can greatly enhance the diagnosis rate to holoprosencephaly complicated with face malformation.

To evaluate the clinical effects of metronidazole-doxycycline gel for treatment of periodontitis, 18 adult patients with periodonti-tis, who had at least 4 mm of probing depth (PD) on the symmetric quadrant, were selected to participate in a randomised study with split-mouth design. Patients of the experimental group were given with metronidazole-doxycycline gel locally once a day for 7 days,while those of the control group were given with metronidazoce stilus. PD, PLI(plaque index), GI(gingival index), BI(bleeding index) were examined on days 0 and 7 of treatment. The results showed that all clinical parametres of the experimental group were better than those of the control group . Therefore, metronidazole-doxycycline gel is effective in the treatment of periodontitis.

Objective To analyze the effect of calcitonin combined with alfacalcidol on clinical outcome,lumbar vertebrae bone mineral density and safety in patients undergoing internal fixation of humeral shaft fracture.Methods 80 patients with humeral shaft fracture treated with internal fixation in Xunwu county people's hospital from June 2010 to June 2016 were selected,and randomly divided into control group and observation group,40 cases in each groups.The control group was given calcium carbonate D3 tablets and functional exercise therapy,the observation group treated calcitonin combined with alfacalcidol on the basis of control group,analysis and comparison the clinical effects,lumbar spine BMD and safety.Results Compared with before treatment,serum calcium level of two groups increased significantly at treatment 2 weeks and 3 weeks(P<0.05);The control group BMD of lumbar spine was significantly increased in treatment 12 weeks(P<0.05),the observation group BMD of lumbar spine was significantly increased in treatment 4 weeks and 12 weeks(P<0.05).Compared with control group,the level of serum calcium in observation group was higher at treatment 2 weeks and 3 weeks (P<0.05),BMD of lumbar spine was higher at treatment 4 weeks and 12 weeks(P<0.05);The total adverse reaction rate of observation group was 10%,the difference was not statistically significant to control group 15%.Conclusion The combination of calcitonin and alfacalcidol treatment of internal fixation of humeral shaft fractures in patients with significant results, can improve serum calcium levels in patients with and improve bone mineral density, and less adverse reactions.

OBJECTIVE: To study the metabolites of phenoprolamine hydrochloride in human body and in human liver microsomes. METHODS: Two volunteers were administrated with 60 mg of phenoprolamine hydrochloride, and plasma samples were collected in specified time points; phenoprolamine hydrochloride was incubated in human liver microsomes. All the metabolites were identified with the LC-MS/MS system. RESULT: One key metabolite was detected in human plasma which m/z was 212.1. Six metabolites were detected in human liver microsomes and the m/z were separately 360.1, 342.2, 415.1, 281.4 and 330.2. Based on metabolite analysis, several metabolic pathways in human body and human liver microsomes were proposed. CONCLUSION: The metabolites of phenoprolamine hydrochloride in human body were different with that in human liver microsomes. We assumed phenoprolamine hydrochloride would metabolize mainly through other pathway but not in the liver. Copyright 2012 by the Chinese Pharmaceutical Association.

Objective To quantitatively assess the neovascularization within human carotid atheroclerltic soft plaque in patients with cerebral infarction using real-time contrast-enhanced uhrasonography. Methods One hundred and forty-two patients with carotid athemselerotic soft plaque were divided into two groups: cerebral infarction group (n = 44)and control group (n = 98).Real-time contrast-enhanced ultrasonography was examined. Acoustics quantitative analysis was made by auto-tracking contrast quantification (ACQ)technology. Results The enhanced intensity (EI)in cerebral infarction group was significandy higher than that in control group[(14.58±4.19)dB vs (11.26±3.77)dB, P< 0.01]. The difference of arrival time (DAT)and the difference of time to peak (DTrP)in cerebral infarction group was significantly shorter than those in control group [(2.21±0.42)s vs (2.46±0.51)s,(2.13 + 0.37)s vs (2.43±0.48)s, P all < 0.01]. Conclusions The real-time contrast-enhanced uhrasonography can provide a new non-invasire and quantitative tool to assess the neovascularizafion within carotid atheroselerofic soft plaque. EI is re-garded as an independent risk factor correhtes strongly with cerebral infarction.

Objective To evaluate the effect of hepatic arterial chemo-embolization( TACE) combined threedimensional conformal radiation therapy (3 D-CRT) in treatment of un- resectable primary hepatocellular cancer (PHC). Methods 80 patients with PHC were divided into TACE therapy(control group) 40 cases and 3D-CRT + TACE treatment( observation group)40 cases,The efficacy and survival rate was observed. Results The rate of effect in observation group were 35 cases (87. 5% ) higher than that 28 cases (70. 0% ) in control group ( x2 = 3. 89, P < 0.05 ) ,The rate of survival in observation group of 1、2、3-year were 67. 5% ,55. 5% ,40. 0% which were higher than that 50. 0% ,27. 5% ,15. 0% in control group( x2 = 3.4576, x2= 3.726, x2 = 3. 635, all P < 0.05), The incidence of adverse reactions in two groups had no significant difference ( P <0.05). Conclusion The three-dimensional conformal radiotherapy combined with transcatheter arterial chemoem-bolization for unresectable primary hepatocellular cancer had a better efficacy,and adverse reactions could be tolerated.