Objective:To study the protective effect and possible mechanism of salvianolic acid B in GK rats complicated with macroangiopathy. Methods:Totally 32 GK rats were randomly divided into four groups:the model group and low,middle and high dose salvianolic acid B groups(40,80 and 160 mg·kg - 1 ),and 8 Wistar rats were used as the normal group. All of GK rats were giv-en high-glucose and high-fat diet. After 16 weeks,GK rats were orally administrated with 10 mg·kg - 1 ·d - 1 N-ω-nitro-L-arginine methyl ester for 8 weeks. At the beginning and the end of the experiment,blood glucose and blood pressure were measured,abdominal aortic blood was collected after anesthesia,thoracic aorta was used to make paraffin sections after bloodletting to observe vasculopathy and the expression of VEGF was detected by Western-blot. Results:The blood glucose was increased in all GK rats with no statistical significance between the drug group and the model group(P > 0. 05). At the end of the experiment,the blood pressure was significant-ly increased in GK rats,indicating that salvianolic acid B could notably reduce the blood pressure in GK rats in a dose-dependent man-ner with statistical significance(P < 0. 05);and it could also remarkably reduce the total white blood cell count and differential blood count,and ameliorate the lesion extent and reduce VEGF expression. Conclusion:Salvianolic acid B has protective effects on aorta in GK rats,and its mechanism may be related with blood pressure lowering,anti-inflammation and reduction of VEGF expression.

The patient takes a supine position, 10-20 needles were inserted thickly with intermuscular needling method in the two rounds, whose centers were both Tianshu (ST 25) and radii were 2 cun. Then, the electric acupuncture apparatus was connected. Meanwhile,bilateral Yanglingquan (GB 34), Sanyinjiao (SP6), Taichong (LR 3), Quchi (LI 11) and Zhigou (TE 6) were needled. Total 60 cases of obesity were treated with these methods, and 30 cases with conservative acupuncture as a control. The treatment results showed that the effective rates were 91.7% and 70.0%, respectively in the two groups.

Objective To investigate the incidence of surgical site infection(SSI)and compliance to bundle inter-vention measures on SSI following total abdominal hysterectomy in patients in department of gynaecology of a tertia-ry first-lass hospital,and evaluate the efficacy of bundle intervention measures in prevention and control of SSI. Methods From March 2014 to October 2015,all gynecology patients undergoing total abdominal hysterectomy were as targeted monitored subjects,March-September 2014 was baseline investigation stage,October 2014 to Oc-tober 2015 was intervention stage(new bundle intervention measures were performed),compliance to bundle inter-vention measures and incidence of SSI before and after intervention were compared.Results A total of 222 episodes of total abdominal hysterectomy were monitored,the incidence of SSI was 5 .86% ,the operation P75 time were 2 hours. Compared with the baseline stage,the compliance to most traditional intervention measures improved after intervention,the largest increase in the compliance to interventions was follow-up after surgery (increased by 64.16% ),followed by preoperative perineal disinfection(increased by 39.07% )and hand hygiene(increased by 21 .34% ). Compliance to new intervention measures was 100.00% . Incidence of SSI following total abdominal hys-terectomy after intervention was significantly lower than before intervention(2.27% [3/132]vs 11.11% [10/90]), difference was significant (χ2= 7.583,P<0.05).Conclusion Targeted monitoring on SSI following total abdomi-nal hysterectomy can improve compliance to bundle intervention measures and decrease incidence of SSI.

[Aim]To study the effects of Ruanganyin on TGF-1,Smad3,Smad7 expressions of the experimental hepatic fibrosis induced by carbon tetrachloride (CCl4) in rats,and to explore its anti-fibrotic molecular mechanism.[Method] Forty healthy Wistar rats were randomly divided into normal control group,vacant control group,CCl4-induced hepatic fibrosis group,and Ruanganyin treated group.The rats in normal group were treated with normal saline by intragastrical irrigation,and the other groups were subcutaneous injected with CCl4 to establish hepatic fibrosis model.The histological changes of the liver tissues were examined by pathological examination.The protein expression of transforming growth factor beta 1 (TGF-1) and Smad3,Smad7 were measured by immunohistochemical technique.[Result] In comparison with those inmodel group,the levels of TGF-1 were significantly decreased after treatment with Ruanganyin.Meanwhile,the levels of Smad3 was also down-regulated.However,the level of Smad7 expression was significantly up-regulated.The pathological changes of liver tissues in Ruanganyin groups were also markedly alleviated.[Conclusion] Ruanganyin has significant inhibitory effects on CCl4-induced hepatic fibrosis in rats,and its mechanism may be associated with the inhibition of TGF-1 expression,down-regulation of Smad3 expression and up-regulation of Smad7 expression.

Adult ; Heat Stroke ; Humans ; Male ; Occupational Diseases

Adult ; Ethylene Dichlorides ; poisoning ; Humans ; Male ; Occupational Exposure

Objective To evualate the clinical efficacy of Minor Bluegreen Dragon Decoction in the treatment of chronic cough.Methods 106 cases of chronic cough were randomly divided into Minor Bluegreen Dragon Decoction in the treatment group of 59 cases, and Compound Liquorice Tablets treatment of 47 cases of the control group, the improvement de-gree of the symptoms (cough and expectoration) were observed before and after treatment.Results The treatment group and the control group the total effective rate were 86.4% and 36.2%, and the treatment group was significantly higher than that in control group (p<0.01).Two groups of cough and expectoration symptom improvement in varying degrees after treatment, but the treatment group was more effective(p<0.05).Conclusion Minor Bluegreen Dragon Decoction treatment of chronic cough patients (excluding other respiratory disease), is effective and safe, which is worthy of clinical promotion.

Objective:To investigate the environmental factors a nd individual personalities of anorectic children in order to improve their nu rsing care.Methods:Forty-six children with anorexia caused by emotional disorders and 50 healthy children were tested by a societa l-psychological factor questionnaire and the Eysenck Personality Questionnaire (Junior) to observe their external environmental factors and individual persona lities,respectively.Results:Encidence of pressures from school work,forced eatin g by parents and family discord emerged more frequently in the anorectic group than in the co ntrol group.Scores in the anorectic group were significantly lower in the scale E level and markedly higher in the scale N level than those of the control group (P<0.01).There was no significant difference between the two groups in the P and L scales .Conclusion:The three factors mentioned above were most closely related to onset of disease, among the factors we observed.Both an intro verted personality and unstable emotions are key,characteristics that can induc e anorexia when affected by these factors.Comprehensive nursing care,mainly cons isting of psychiatric-behavioral correction,is proposed to obviate the inducing factors and rectify emotional disorders to promote recovery from anorexia.

Purpose:To investigate the therapeutic effect of PEFC chemotherapy regimen (cisplatin or carboplatin,etoposide,fluorouracil and cyclophosphamide) on primary carcinoma of fallopian tube.Methods:41 patients with primary carcinoma of fallopian tube were divided into two groups: 20 patients in PEFC group received PEFC chemotherapy; 21 patients in CAP group received CAP chemotherapy. The therapeutic effects of the two groups were compared.Results:1 , 3 , 5 year progression free survival rate of PEFC group and CAP group were: 100%, 67.34%, 67.34%; 76 19%, 51 88%, 45 40% respectively ( P

Objective To examine and assess the clinical effect of Er ∶ YAG 2940 nm fractional laser resurfacing for skin wrinkles.Methods A total of 16 patients with Fitzpatrick skin type Ⅳ and facial wrinkles,were treated with Er ∶ YAG 2940 nm fractional laser resurfacing and follow-up were given every week after treatment,four weeks in all.Response to treatment was evaluated by observers and patients themselves.Photos were analyzed by the photoshop 12.0 software.Results During the four-week follow-up,the skin of patients was more and more better than pretreatment,and a large part of wrinkles was disappeared.The assessment of observers for wrinkle amelioration rose from (6.50--2.33) ％ to (34.80±5.24) ％ and the scores of content of patients was up to 4.00±0.27(generally satisfied),whereas no one satisfied at beginning.Analyzed by photoshop 12.0 software,the data of average and middle values were on the trend of increasing in all these four weeks while SD was basically on the trend of decreasing.Conclusions Fractional ablative photothemolysis using Er ∶ YAG 2940 nm laser is a promising option for skin wrinkles.