Objective To investigate the influence of Enalapril Maleate Tablets on serum micro inflammatory indexes and nutritional indexes in maintenance hemodialysis patients. Methods A total of 90 patients with chronic renal failure treated by maintenance hemodialysis in our hospital from April 2015 to October 2016 were randomly divided into control group and experimental group, with 45casesin each group. The control group was treated with atorvastatin,andthe observation group was treated with atorvastatin combined with enalaprilmaleate tablets. After treatment,the levels of the inflammatory markers of high sensitive C reactive protein (HS-CRP), tumor necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8), interleukin 6 (IL-6) and the nutritional index of plasma albumin(ALB), prealbumin(PA) in two groups were analyzed. Results After treatment, the levels ofHS-CRP, TNF-alpha in the observation group were lower than those in control group, the difference was statistically significant (P<0.05); The levels of IL-6, IL-8 in the observation group were significantly lower than the control group, the difference was statistically significant (P<0.05). The indexes of ALB and PA in the observation group after treatment were higher than those in the control group, the difference was statistically significant (P<0.05). Conclusion For the patients with maintenance hemodialysis treatment, the clinical effect of using conventional atorvastatin treatment combined with Enalapril Maleate Tablets is good, high safety, with further clinical promotion and application significance.

Objective To investigate the expression changes of aquaporin-1 (AQP1) and aquaporin-9 (AQP9) in rats after traumatic brain injury, and explore the roles of AQP1 and AQP9 in the development of brain edema.Methods In an impact-acceleration head injury model of rat, brain water content was measured by wet-dry weight method at 1 h, 6 h, 24 h, 48 h and 168 h after brain trauma. The expressions of AQP1 and AQP9 in brains were investigated by immunohistochemistry and Western blot.Results Brain water content increased in the injuried brain tissues after 1 h post-injury, reached peak at 24 h and returned at 168 h. Both expressions of AQP1 and AQP9 were induced in reactive astrocytes adjacent to injury sit at 6 h and 24 h after brain trauma. Staining of AQP1 in the endothelial cells was not present in normal rat brains but appeared strong after brain trauma.Conclusion A remarkable induction expression of AQP1 or AQP9 after brain trauma may participate in the development of brain edema.

To study the effect of a program of physical therapy,40 subjects with total hip replacement for femoral neck fracture were randomized into rehabilitation and control groups.The program included ROM exercises,low resistance exercises of hip abductors and ADL exercises.Muscle strength of hip abductors were measured by Kendall's Muscle Testing and Function,hip ROM,functional ability and pain were evaluated by Harris Hip score on the lst and 3rd month after surgery.Statistical analysis with t test was used for comparing Harris Hip scores.The result shows that muscle strength and hip function were improved significantly in rehabilitation group (p<0.05).That means the program is effective in long term after hip replacement.

ObjectiveTo investigate the complication and nursing of intestines nutrition in critical patients after operation. MethodsThe clinical states of 40 patients after operation and being brought to ICU were analyzed.ResultsPatients accepting intestines nutrition presented high incidence of gastrointestinal complications. ConclusionIt is important to pay attention to prevent gastrointestinal complications in patients accepting intestines nutrition early postoperation.

Pancreatic cancer is one of the most malignant diseases.With the development of biology,its pathogenesis has become more and more clear.There are a lot of signal pathway aberrant in pancreatic cancer cell including Notch signal pathway,k-ras signal pathway,hedghog signal pathway,NF-κB signal pathway and so on.Because of the widespread of NF-κB signal pathway aberration in pancreatic cancer cell,we think that NF-κB play a key role in the various kinds of aberrant signal pathways.So the NF-κB relative sighal pathways in pancreatic cancer are reviewed in this atticle.

Objective To investigate the clinical effect of percutaneous balloon angioplasty for the treatment of arteriovenous fistula stenosis or occlusion in upper extremity in hemodialysis patients. Methods Percutaneous balloon angioplasty was performed in 14 hemodialysis patients with arteriovenous fistula stenosis or occlusion in upper extremity. The preoperative and post operative clinical manifestations, the color Doppler ultrasonographic findings, the blood flow during hemodialysis and the angiographic demonstrations were recorded and compared. Results After balloon dilatation, the constricted segment was remarkably dilated and the occluded site was re-opened in all patients. Angiographic findings showed that the degree of stenosis was less than 30%. Conclusion As a simple, mini-mvasive and safe technique with remarkable short-term effectiveness, percutaneous balloon angioplasty is an valuable therapy for arteriovenous fistula stenosis or occlusion in upper extremity in hemodialysis patients.

As a new biotechnology, protein transduction connects the target fragment with biology active and protein transduction domain, and transducer it in to cells, exert its biological effects. Protein transduc-tion domain is a small molecule peptide, not only the protein transduction domain can penetrate through cell membrane, but could maintain the activity of its fusion protein. Protein transduction is an emerging biology technology, it has been applied into all aspects of cell gene regulation since its invention. In this article, we take Tat, Pdx-1 and Beta/NeuroD for instance and review the application of transduction protein in the dif-ferentiation of pancreatic stem cell.

Objective To study the expression changes and profiles of nuclear structure and biogenesis-related genes in rat liver regeneration(LR). Methods Genes involved in nuclear structure and biogenesis were obtained by data collection and literature review.The gene expression changes during LR were checked by Rat Genome 230 2.0 array,and LR-related genes were identified by comparing gene expression difference between partial hepatectomy(PH) and sham operation(SO) groups.Results 406 genes were found to be LR-related.The numbers of initially and totally expressed genes occurring in the forepart(0.5-4 hours after PH) of LR,the prophase(6-12 hours after PH),the metaphase(12-66 hours after PH),and the anaphase(72-168 hours after PH) were 200,29,179,5 and 374,290,1?876,603,respectively.The numbers of their up-regulation and down-regulation were 1?224 and 496 times.The elevated transcription levels occur red to the nuclear organization and biogenesis-involved genes in the prophase and the metaphase of LR and to the nuclear membrane,nuclear matrix and nucleoplasm-involved genes in the metaphase;nuclear chromosome,nucleolus and nuclear functional protein complex-involved genes were up-regulated in the metaphase and the anaphase.Conclusion The expression of nuclear structure and biogenesis-related genes was active during LR,and it was tightly related with LR.

OBJECTIVE To investigate the expression of keratinocyte growth factor(KGF)in middle ear cholesteatoma and to explore the role of KGF on the hyperproliferation of the cholesteatoma epithelium and the formation and development of cholesteatoma. METHODS The specimens from the cholesteatoma tissue of 20 cases and the corresponding normal external ear skin were examined by immunohistochemical S-P method and quantitative analysis. RESULTS In normal ear skin only stroma staining for KGF was positive. In cholesteatoma epithelium staining for KGF was strongly positive and the stroma staining was stronger than that of normal ear skin. The positive rates of the cholesteatoma and normal external ear skin revealed a significant difference. There was a positive correlation between cholesteatoma epithelium staining for KGF and for Ki67 and the coefflcient of correlation was 0.609(P﹤0.01). CONCLUSION There was correlation between the expression of KGF or Ki67 and the ability of reproduction of middle ear cholesteatoma. Local inflammation might promote hyperproliferation of the epithelium of cholesteatoma by regulating the expression of KGF. It suggested that an autocrine stimulation of KGF correlate with the occurrence and development of cholesteatoma .

Autophagy is a physiological process which delivers the mutant cytoplasmic proteins and dysfunctional subcellular organs into lysosomes for degradation to generate fuel in the deficiency conditions. It is mainly classified into macroautophagy, microautophagy and chaperon-mediated autophagy (CMA), as well as the selective autophagy such as mitophagy and aggrephagy. This review mainly introduces the key molecular markers of macroautophagy, CMA and mitophagy.
Autophagy ; Humans ; Lysosomes ; Mitochondrial Degradation ; Molecular Chaperones