OBJECTIVE: To discuss the importance of developing the capability and skills of communication in clinical pharmacy.METHODS: The method of communication in clinical pharmacy was introduced by combining the author's own work experience.RESULTS & CONCLUSION: The communication in clinical pharmacy work comprises the professional communication with physicians and nurses as well as the psychological communication with patients about medication.Assisted by clinician,clinical pharmacists' communication skills can be enhanced through improving their own expertise and psychological knowledge.The developing of communication ability is an important part in clinical pharmacy training.

Adult ; Cell Differentiation ; Female ; Granulosa Cell Tumor ; pathology ; surgery ; Humans ; Microtubules ; pathology ; Neoplasm Metastasis ; Neoplasms, Multiple Primary ; pathology ; surgery ; Ovarian Neoplasms ; pathology ; surgery ; Sertoli Cell Tumor ; pathology ; surgery ; Sex Cord-Gonadal Stromal Tumors ; pathology ; surgery

Objective To investigate the value of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of pulmonary cryptococcosis.Methods 15 patients who were diagnosed as pulmonary cryptococcosis were retrospectively studied,all of them were examined by sputum smear,X ray,CT and EBUS-TBNA.Results 15 patients who received EBUS-TBNA were diagnosed pulmonary cryptococcosis by pathological methods and germiculture,during the process no complication was detected.Conclusion EBUS-TBNA is a safe and effective means in the diagnosis of pulmonary cryptococcosis for pulmonary cryptococcosis patients hard to be diagnosed clinically.

Objective: To understand and solve the problems in health education in intravenous infusion among elderly patients with cardiovascular disease.Methods: An investigation was conducted with a self-designed questionnaire among 127 elderly cardiovascular disease patients receiving intravenous infusion,with the purpose of finding out specific problems concerning the education so as to adopt effective countermeasures.Results: Among the patients investigated,88.9% considered the contents of the health education to be too simple,50% thought of the nurses as lacking in initiative,19.8% deemed the nurses short of expertise,and 41.3% thought that supervision had to be emphasized in the management of health education.Conclusion: Systematic,comprehensive and scientific health education in intravenous infusion plays an important role in ensuring the safety and improving the satisfaction rate of intravenous infusion among elderly patients with cardiovascular disease.

Low-dose chemotherapy is concerned in treating malignant tumor in recent years.The lowdose,metronomic chemotherapy is not only effective in antiangiogenic,but also avoid chemotherapy side effects,such as suppression of bone marrow,dysfunction of liver and kidney,gastrointestinal reaction and drug resistance.Thereby it can increase patient compliance,improve life quality and prolong survival time.Currently chemotherapy in neuroblastoma still plays a key role,especially low-dose chemotherapy,which can protect self-immune function and reduce the physical injury in children.

Objective To establish the Sprague-Dawley rats psychological stress model and investigate the effect of the psychological stress on behavior and condylar cartilage of Sprague-Dawley rats. Methods Sprague-Dawley rats were randomly divided equally into psychological stress group, foot shock group and control group, and the foot shock group was only as sources of stimuli. The Sprague-Dawley rats psychological stress model was built, and the rats were killed at 1, 3 and 5 weeks respectively after stimulation. The behavior changes were observed by open field test,etc. The histology of condylar cartilage was observed by HE stain. Results Psychological stress model was effective in evaluating behavior changes. The pathological examination revealed structural changes of the condylar cartilage in the psychological stress group. The psychological stress groupⅡwas the most serious group with collagenous fibers disintegrated and gaps formed. Conclusion This rats model of the psychological stress shows great practicability and reproducibility. The long-term psychological stress can lead to SD rats behavior changes and temporomandibular joint condylar cartilage change.

Humans ; Immunohistochemistry ; Lymphoma, Large B-Cell, Diffuse ; classification ; pathology

Objective:To study the relationship between detection of Helicobacter pylori(H.pylori)infection with 13 C urea breath test( 13 C UBT)and gastric cancer.Methods: 13 C UBT were carried out in 53 cases of gastric cancer patients at 3 days before operation and 10 days after operation.Thirty six healthy individuals were detected as normal control.The rate of H.pylori infection in gastric cancer patients was calculated and compared.Results:The rate of H.pylori infection of the healthy control group was 0,but that of the early or advanced gastric cancer groups were 75% and 65.8% respectively (P

Aim To obtain more valuable derivatives for the further structural modification of 6β-santonin (1) via biotransformation by using cell suspension cultures of Phytolacca acinosa. Methods The substrate 1 was incubated with cell suspension cultures of P.acinosa, the products were obtained by chromatography, and identified on the basis of their physical and spectral data (HRMS, 1D NMR, 2D NMR, NOE and IR). Results After incubation with cell suspension cultures of P.acinosa, 1 was converted into five products (2-6). Among them, 3 is a new compound. Conclusion 6β-santonin could be selectively reduced and hydroxylated by the cell suspension cultures of P.acinosa, which would provide valuable intermediates for its further structural modification.

Objective To study the relationships between serum matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of matrix metal]oproteinase-2 (TIMP-2) with bone metabolic markers and bone mineral density (BMD) in postmenopausal Chinese women.Methods In this study,192 postmenopausal Chinese females aged 48-65 were selected.Serum MMP-2,TIMP-2,bone alkaline phosphatase (BAP),osteocalcin,bone cross-linked C-telopeptides of typeⅠcollagen (CTx) and urine bone cross-linked N-telopeptides of typeⅠcollagen (NTx) were measured by ELISA.And the ratio of MMP-2/TIMP-2 was calculated.BMD was measured by dual energy X- ray abserptiometry.According to the criteria of WHO,these women were assigned to 3 groups : the normal,the low BMD and the osteoporosis groups.Results (1) Serum MMP-2 level was significantly higher in postmenopausal women with osteoporosis (1388?121)?g/L than that in age-matched normal controls (1126?141)?g/L (P0.05).(2) Notable negative relations were found between MMP-2,ratio of MMP-2/TIMP-2 with BMD of lumbar spine and Ward's triangle,serum BAP and osteocalcin (all P0.05).(3) In osteoporosis women,notable negative correlations between MMP-2,ratio of MMP-2/TIMP-2 with BMD of lumbar spine,femoral neck and Ward's triangle,serum BAP and osteocalcin were found (all P