Sudden cardiac arrest is one of the critical clinical syndromes in emergency situations. A cardiopulmonary resuscitation (CPR) is a necessary curing means for those patients with sudden cardiac arrest. In order to simulate effectively the hemodynamic effects of human under AEI-CPR, which is active compression-decompression CPR coupled with enhanced external counter-pulsation and inspiratory impedance threshold valve, and research physiological parameters of each part of lower limbs in more detail, a CPR simulation model established by Babbs was refined. The part of lower limbs was divided into iliac, thigh and calf, which had 15 physiological parameters. Then, these 15 physiological parameters based on genetic algorithm were optimized, and ideal simulation results were obtained finally.
Algorithms ; Cardiopulmonary Resuscitation ; Death, Sudden, Cardiac ; Electric Impedance ; Hemodynamics ; Humans ; Leg ; Models, Cardiovascular

· Mesenchymal stem cells ( MSCs ) are a population of multipotent stem cells with various neurotrophins from bone marrow which are widely used in tissue, cell repair and alternative research.Recently, some researches have shown that MSCs could enhance the viability of neurons under a pathological circumstance by secreting some neurotrophins. So the neuroprotection of MSCs can provide a new method of the treatment on retinopathy that it possible to promote cells survial and functional recovery.Here we make a brief review on the secretory function of neurotrophin and neuroprotective effects of MSCs on retinal cells and its application in the treatment of retinal disease.

Long non-coding RNAs ( LncRNAs) are a class of RNA transcripts greater than 200 nt in length without the func-tion of protein encoding.LncRNAs, which consist of a great variety of categories and structures, regulate the associated gene expression on multiple levels, including chromatin modification, transcriptional and post-transcriptional regulation, and epigenetic modification. Moreover, LncRNAs are widely involved in the physiological and pathological processes.Recently, a large number of studies have found that the abnormal expression of LncRNAs is closely related to the occurrence, development, invasion and metastasis of tumor, and plays an essential role in pathogensis of colorectal cancer.In this paper, the function of LncRNAs in colorectal cancer is reviewed, which provides a theoretical evidence for its use in the diagnosis and treatment of colorectal cancer in clinical study.

Objective To explore the effect of the joint teaching rounds of the multidisciplinary radiotherapy.Methods 54 clinical college students of Grade 2013 was selected as the control group,adopting the traditional single teaching ward round model,while 58 clinical college students of Grade 2014 was selected as the research group,adopting the multidisciplinary joint radiation operation mode.By contrasting the satisfaction questionnaire,calculating and delineating the target volume error rate and the theory examination results,the effect of teaching ward round was evaluated.Results ①According to the survey,the research group's satisfaction in teaching methods,stimulating students' enthusiasm for learning,improving their clinical thinking ability and consolidating the knowledge (respectively 91.38％,86.21％,82.76％,93.10％),was higher than that of the control group (75.93％,68.52％,62.96％,77.78％),and the difference was statistically significant (chi square values were 4.95 5.05,6.25,5.36;P＜0.05).②The research group's pass rate in delineation of Gross Target Volume (GTV) and the Clinical Target Volume (CTV) was (82.76％,86.21％),higher than that of the control group (53.70％,62.96％),and the difference was statistically significant (chi square values were 14.36,9.48;P＜0.01).③Research group's score in clinical Three Basics and oncology theory achievement was(88.75 ± 5.23) and (82.72 ± 3.69),higher than the control group [(81.88 ± 613),(80.74 ± 3.25) points],and the difference was statistically significant (t=6.40 respectively,3.01;P＜ 0.05).Conclusion Radiotherapy department's multi-disciplinary joint ward round helps to improve the teaching quality.

Objective To study the application value of the cervical cell pathology liquid production technol-ogy in cervical intraepithelial neoplasia (CIN)screening.Methods 4 212 patients were chosen and detected by TCT and the pap staining,TBS (the Bethesda system)to finish thin layer liquid based cytology grading diagnosis,including 558 patients with cervical biopsy,the pathological results were analyzed.Results for histopathological examination results of CIN1,CIN2,CIN3 and cervical cancer cases,a thin layer of liquid based cytology detection rate was 76.00%(57 /75),78.21%(61 /78),95.76%(113 /118),100.00%(7 /7),the comparison between the CIN3 CIN2 group,a thin layer of liquid based cytology detection rate had differences in significant statistical significance (χ2 =14.53,P <0.01),with the histopathological detection of cervical lesions,thin layer of liquid based cytology detection rate was obviously rising trend.Cervical liquid based cytology screening cervical lesion (CIN and above),the sensitiv-ity was 85.61%(238 /278),83.73%(206 /246),positive predictive value 76.28%(238 /312),negative predictive value 72.79%(206 /283).Conclusion The positive results and histopathological results coincidence rate of using thinprep cytologic test to screening for cervical intraepithelial neoplasia (CIN)is high,the precancerous lesions in screening and prevention has important significance,which is worth clinical promotion.

Objective To explore the influence of follow-up by telephone on adherence and quality of life for breast cancer patients with hormonal therapy.Methods Totally 78 breast cancer patients with hormonal therapy were divided into the intervention group (40 cases) and the control group (38 cases).The control group were carried on routine guidance treatment and enjoined regular subsequent visit.The patients in intervention group were carried on the above-mentioned treatment and also receive regular follow-up by telephone.Through the follow-up by telephone we provided guidance for present and will present problems.Adherence for breast cancer patients with hormonal therapy and cancer rehabilitation evaluation system-short form(CARES-SF) were used to investigate the patients' adherence and quality of life six month after the intervention.Then we compared the adherence and quality of life before,six month of the intervention.The changes of adherence and quality of life scores were analyzed by repeated-measure ANOVA.Results The score of quality of life in the intervention group after 6 month of intervention was (25.43 ± 6.04),while in the control group was (40.61 ± 7.73),the difference was significant between the two groups,P＜0.05.The score of medication adherence in the intervention group after 6 month of intervention was (8.57 ± 6.20),while in the control group was (14.12 ± 6.63),the difference was significant between the two groups,P＜0.05.Conclusion Follow-up by telephone can improve adherence and quality of life for breast cancer patients with hormonal therapy.

Liver metastasis is the leading cause of death from colorectal cancer.Surgical treatment is so far the best choice for the treatment of colorectal liver metastases (CRLM).However,how to suitably select an individualized chemotherapy in perioperative period and surgical time and tool is still under controversy.Therefore,the key factors of improving the prognosis of patients with CRLM include overall evaluation of the patients and their preoperative examination outcomes,dividing patients into different groups based on different therapeutic goals,understanding different therapeutic goals of each group,selecting suitable chemotherapy and targeted therapy,ensuring surgical time (synchronous or stepwise resection) and tools (minimally invasive or open surgery) through multidisciplinary team model.

Targeted therapy such as the epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI)has made huge progress in treatment of non-small cell lung cancer (NSCLC).However,the emergence of acquired drug resistance is an inevitable result of the targeted therapy.The hepatocyte growth fac-tor/c-mesenchymal-epithelial transition factor (HGF /c-Met)signaling pathway participates in cell formation, migration,angiogenesis and other important cellular processes of multiple tumors.The abnormal activation of this signaling pathway plays the pivotal role in the acquired resistance to EGFR-TKI.Recently,some clinic tri-als prove that HGF /c-Met inhibitors can make clinical benefit of some NSCLC patients with acquired drug re-sistance of EGFR-TKI.

With the development of mass spectrometry technology and its wide range of applications in the biological field,Veristrat classifier has been applied in non-small cell lung cancer (NSCLC) individualized therapy as well as in other tumors.Oncologists select individualized treatment plan based on peripheral blood veristrat test results.Many trials have verified its guiding role in NSCLC and other tumors' s first line and multi-line individualized therapy.Veristrat classifier provides a new idea and method for individualized treatment of NSCLC and other tumors.

Objective We aimed to translate the English version of Patient Dignity Inventory (PDI) into Chinese and test the reliability and validity of the Chinese version of PDI in terminal stage patients.Methods Totally 285 patients in terminal stage was recruited and investigated by the Chinese version of PDI.Results The internal consistency coefficient of the Chinese version of PDI ranged from 0.728 to 0.953,which was ＞0.70; split half coefficient was 0.561; the test-retest reliability was 0.824,which showed that internal consistency of Chinese version of PDI was good.The content validity index was 0.912.Factor analysis got five factors,which explained 62.172％ of the total variance; the factor loading of each item was ＞0.4.Conclusions The Chinese version of PDI has been proved to be reliable and valid.It can be used as a valid tool for the measurement of dignity in terminal stage patients.