OBJECTIVE:To study the effects of Ershiwuwei zhenzhu wan(ZZW)on cerebral edema induced by cerebral ischemia of rats.METHODS:The incomplete cerebral ischemia model was induced by occlusion of arteria carotis in rats,the effects of ZZW on cerebral capillary permeability,cerebral index and cerebral water content were observed by azo-blue method and weighting method.RESULTS:Preventive medication of ZZW could significantly decrease cerebral capillary per-meability,cerebral index and cerebral water content and palliate cerebral edema(P

The serum sialic acid level and its relation to stroke in syndrome X was observed in 21 syndrome X patients with history of stroke,21 syndrome X patients without history of stroke, 21 simple NIDDM patients and 21 healthy subjects matched for age, sex, duration of diabetes and HBAlc level.The results showed that the serum sialic acid level was significantly higher in all NIDDM patients than in normal subjects(P

Objective To investigate the association between the gastroesophageal reflux and functional bowel disorder.Methods 168 patients with epigastric symptomswere involved in the survey.A validate questionnaire on gastroesophageal reflux symptoms was performed by the physician.There were 68 patients in the Sc≥12 group and 100 patients in the Sc

Objective To identify the factors that may influence the risk of relapse.Methods 122 patients were included in the study,and 12 clinicopathologic factors related to the relapse of ulcerative colitis were analyzed by univariate and multivariate Cox regression proportional hazards mode.Results Multivariate analysis showed the exatrointestinal manifestations,Induced factors,irregular therapy and the compliance of patients were independent prognostic factors for the relapse of ulcerative colitis.Conclusion The patients with UC should be treated regularly and avoid inducing factors.When patients have exatrointestinal manifestations,they should be monitored closely to prevent relapse.

Objective To describe the experience of nurses in combined care program of traditional Chinese medicine (TCM) and provide references for nursing managers. Methods The phenomenology research method was adopted in this study. Fourteen nurses who had achieved the combined care program of TCM participated in an in-depth interview. Data were analyzed by using phenomenological analysis. Results All nurses approved nursing program of TCM: finding sense of belonging in nursing work;demonstration of self-value;standardization of nursing tednnique;harmonious environmont of nursing work. But some defect still existed: too subjective evaluation item of nursing program of TCM;inappropriate evaluation table;lact of hospital characteristics of TCM nursing;deficiency of TCM knowledge. Conclusion Nursing managers should pay more attention to nurses' emotional experience, grasp the implementation of the problems during the program and improve the program, optimize the skills, provide trainings.

Objective To investigate the effects of aerosolized Dexamethsone inhalation on circulatory and respiratory function during lung injury (ALI) induced by hydrochloric acid (HCI) aspiration.Methods Twenty-four healthy pigs of either sex,weighting (15.5±2) kg were anesthetized with intraperitoneal injection of pentobarbital sodium 50mg/kg and intubated and mechanically ventilated (FiO2=1.0,VT=10-15 ml/kg,RR=16bpm,I:E=1:2).Anesthesia was maintained with infusion of Ketamine,procaine and succinylcholine.Femoral artery was cannulated for MAP monitoring and blood sampling.Swan-Ganz catheter was placed in the pulmonary artery via right inexternal jugular vein.Dilute HC1 (0.1mol/L) was instilled via trachea into lungs until PaO2 was＜13.3kPa.Arterial blood gases,MAP,MPAP and dynamic compliance were measured before induction of ALl (T0),when ALI was induced (T1) and 1,2,3 and 4(T2～5)there after.The pigs were then divided randomly into three groups according to the treatment they received:group A received IPPV alone,group B IPPV+PEEP(0.69kPa) ,group C IPPV+PEEP(0.69kPa)+aerosolized Dexamethasone (12.5ugokg-loh-I).Results MAP decreased significantly after induction of ALI in three groups hut there was no significant difference in MAP among the three groups (P＞0.05).MPAP increased significantly after induction of ALI in all groups and remained high during the period of T2～5 in group A and B (P＞0.05),hut decreased significantly from T2 in group C (P＜0.05 ).PaO2 increased significantly during the treatment in group B、C(P＜0.05),and was significantly higher in group C than that in group B (P＜0.05).PaCO2 in group A was highest in three groups (P＜0.05) and group C was lower in three groups (P＜0.05).Dynamic lung compliance decreased in all animals after induction of lung injury (P＞0.05),but was gradually increasing significantly during treatment(B、C group) (P＜0.05).Conclusion Aerosolized Dexamethasone inhalation can improve respiratory function during ALI induced by HC1 aspiration and reduce pulmonary hypertension,but dont impair MAP.Both have the same effects on the treatment of lung injuries.

Objective In order to summarize the common characters of medical education , this research Compared curricula and educational reformation of different counties .The common characters of international medical educa-tion are useful to China's current medical education reformation .Methods This research used method of compara-tive education study to compare the medical education of the U .S, the U.K and Japan.Results Although the medical education program length is different in the 3 countries, they all recognize medical education as professional education .So they all adopt muti-method to test candidates .The curriculum frameworks of medical education pro-gram of 3 countries are different , but the curriculum organization , teaching methodologies , assessment methods are similar.They all have complete quality control system .As the medical education reformation , about half of medical schools in the U .K and Japan have implemented graduate entered medical education program .Conclusions Al-though medical education program length is different in the U .S, the U.K and Japan, they do share some charac-ters.These common characters are useful to medical education reformation and quality control in China .

Objective:Try to study the effect of short-term psycho-intervention on mental status,medical coping mode,social supports and mood states in patients with maintance hemodialysis(MHD).Methods:61 MHD patients from Nol Wuhan Hospital were divided into intervention group and control group.The short-term psycho-intervention included healthy education,supportivc psychotherapy,circumstance therapy and education to patient's relatives.All patients' social psychology status were assessed at baseline and end of intervention by three questionnaires,such as Medical Coping Mode Questionnaire (MCMQ),Social Support Ouestionnaire and Profile of Mood States.Results:After intervention,most psychology indexes of intervention group improved. Acceptance-Resignation score decreased from 12.5?3.7 to 9.3?2.5,avoidance score decreased from 16.5?2.9 to 14.4?2.7,subjective support score increased from 16.2?5.6 to 21.6?5.1,support using score increased from 6.4? 2.3 to 8.8?2.8,Total support score increased from 32.5?8.1 to 38.9?6.7.Tension-Anxiety score decreased from 14.1?6.7 to 10.1?5.2,Depression-Dejection score decreased from 22.9?14.5 to 16.2?10.2, Anger-Hostility from 16.6?10.1 to 11.5?8.6,Confusion-Bewilderment decreased from 11.9?4.8 to 9.1?4.2,but Vigor-Activity increased from 10.3?6.2 to 15.1?5.4.There was no significant change in control group.Conclusion:Short-term psycho-intervention can improve medical copying mode,social support and mood states in MHD.

Posttraumatic stress disorder (PTSD) is a psychiatric condition that can occur in anyone who has experienced a life-threatening or violent event.Research into the underlying neurobiology has implicated dysregulation in multiple neurotransmitter systems including norepinephrine,serotonin and glutamate as well as the hypothalamic-pituitary axis.Although there was a tremendous growth in the understanding of PTSD in the past few years,the specific neurobiological underpinnings of PTSD wait for more explorations.

Objective:To explore the influence of resveratrol on blood lipid level and expression of adipose differenti-ation related protein (ADRP)in atherosclerosis (AS)model rabbits.Methods:A total of 36 New Zealand rabbits were randomly and equally divided into normal control group,AS model group,low dose resveratrol group (low dose group)and high dose resveratrol group (high dose group).Rabbits received 15-week administration,expression level of serum lipoprotein,ADRP and ADRPmRNA expressions in adipocytes of rabbit aortic tissue were measured and compared among all groups before and after treatment.Results:Compared with AS model group at the end of 15th week,there were significant reductions in serum concentrations of total cholesterol [TC,(18.25±4.35)mmol/L vs.(12.79±2.45)mmol/L,(10.35±2.80)mmol/L],triglyceride [TG, (3.15±0.94)mmol/L vs. (2.63± 0.75)mmol/L、(1.18±0.64)mmol/L]and low density lipoprotein cholesterol [LDL-C,(15.18±3.65)mmol/L vs.(8.35±1.15)mmol/L,(7.18±1.75)mmol/L],and significant rise in level of high density lipoprotein choles-terol [HDL-C,(1.02±0.36)mmol/L vs.(3.22±1.02)mmol/L,(2.72±0.82)mmol/L]in low dose group and high dose group (P <0.05 or <0.01),and significant reduction in level of triglyceride [TG,(3.15±0.94)mmol/L vs.(1.18±0.64)mmol/L]in high dose group,P <0.01;ADRP histochemical staining [(0.43±0.05)vs.(0.35± 0.04),(0.38±0.15)]and ADRPmRNA expression [(2.47±0.94)vs.(1.30±0.49),(1.83±0.61)]significantly weakened in adipocytes of aortic tissue in low dose group and high dose group,P <0.01 all. Conclusion:Resveratrol can inhibit the overexpression of ADRP and its mRNA in adipocytes of aortic tissue in AS rabbits,reduce blood lipid levels,and help to delay the AS progression.