Acute myeloid leukemia (AML) is considered to be an irreversible change of gene function caused by certain genetic changes, resulting in abnormal proliferation, differentiation disorder, and abnormal apoptosis of leukemia cells, leading to the occurrence and development of leukemia. Epigenetics refers to the change of heritable gene expression but the gene does not change in sequence. A large number of studies have shown that the pathogenesis of AML is closely related to the regulation of epigenetics. The regulation of epigenetic modification in the cellular metabolism, immune microenvironment and immune response of AML has been received increasing attention. This review will describe the regulation of epigenetics in the cellular metabolism, immune microenvironment and immune response of AML and the advances in the targeted intervention measures.

Objective To comprehend the status of treatment compliance, self-efficacy and social support of patients with chronic hepatitis B ( CHB ) , and to investigate the correlation among them.Methods The investigation had been carried out with treatment compliance questionnaire, health behavior self-efficacy scale, and social support rating scale among ninety two cases with CHB.Results The overall score of treatment compliance in Patients with CHB was (33.80 ±3.28), while the lowest score was medical treatment only (9.85 ±1.44);self-efficacy acquired (66.28 ±13.78), in which the high level had 24 cases(26.09%), the middle level 60 case (65.22%), and low level 8 cases(8.69%);the social support gained (41.67 ±5.32). There were positive correlations between the treatment compliance with self-efficacy and social support ( r =0.482,0.711, respectively;P <0.01 ) .Conclusions Patients with CHB have poor treatment compliance;however, high level of self-efficacy and favorable social support can improve treatment compliance.