No abstract available.
Colorectal Neoplasms* ; DNA* ; Ploidies*

We analyzed the predonation tests and the characteristics of plateletpheresis of the candidates and donors during 18 month at Korea University Guro Hospital from 1993 to 1995. Among the 810 candidates tested for predonation tests, 115(14.2%) candidates were deferred due to incompatible factors. The most common incompatible factor is elevated alanine aminotransferase(4.6%, ALT > 64 Iu) followed by incompatible ABO discrepancy (4.1%), positive HBsAg(3.3%), low platelet count(2.2%). 43.1 percent of the platelet donation candidates were processed plateletpheresis. 43(18%) of prospectively reviewed 240 plateletpheresis donors were relatives of the recipients. The percent of redonation was only 14% and its mean interval was 11.4 days. The result showed the plateletpheresis candidates have the relatively safety compared to that of the directed donation, social support of plateletpheresis donation program is strongly needed because of low redonation rate and characteristics of plateletpheresis donation.
Alanine ; Blood Platelets ; Directed Tissue Donation ; Fibrinogen ; Humans ; Korea ; Plateletpheresis* ; Prospective Studies ; Tissue Donors*

Bony changes about the elbow in the baseball players are common problem. Pure bony injuries occur in the elbow of the throwing arm, but most often they have some associated soft tissue counterpart. The importance to understand the elbow lesion in baseball players is that many of this lesion seem mild at onset and can often be easily managed, but permanent disability can result from the delayed or inadequate treatment. The authors have performed radiological study in 32 professional baseball players and obstained following result. 1. Among 32 baseball players we studied, twenty-four plsyers(75.0%) had 41 bony changes in the throwing elbow. 2. Forty one bony changes were classified into three groups by Slocum classificstion,;twenty nine medial tension overload injury, eleven extensor overload injury and one lateral compression injury. 3. Incidences of bony changes in each age group were 63.6#% in 20~24 years, 71.4% in 25~29 years and 100% in 30~35 years of age. 4. Incidences of bony changes in each csreer group were 63.6% in 10~14 years, 69.2% in 15~19 years and 100% in 20~25 years of career. 5. Incidences of bony changes in each position were 72.7% in the piteher and 76.2% in the fielder. 6. In conclusion, the best treatment is prevention, namely, exercise to increase the stren- gth, flexibility, and endurance of elbow musculature, which should be coupled with attention to proper mechanics of throwing. If an injury does take place, prompt treatment consisting rest, physical therapy and appropriate medicstion when indicated-should lead to a successful result in most cases.
Arm ; Baseball ; Elbow ; Humans ; Incidence ; Mechanics ; Pliability

No abstract available.
Gallbladder* ; Lithotripsy*

Cholelithiasis is defined as the presence of stones within the lumen of the gallbladder or in the extrahepatic biliary tree. Cholecystitis, secondary to gallstones, is a common surgical disorder in Korea. Detailed microscopic descriptions, particularly the ultrastructural changes, of these diseases were not available. The goal of this study was to identify the ultrastructural alterations of gallbladder epithelium in cholecystitis with and without a stone, according to the degree of severity of inflammation, and the nature of the stone. The gallbladders of the control group, and cholecystitis cases without stone and with stone were fixed and examined with routine stain, special stain, immunohistochemical stain and trans-mission electron microscopy. The number and the volume density of the mucin containing secretary granules were not significantly increased in the calculous cholecystitis cases compared with those of the acalculous cholecystitis cases. Major findings were that the calculous cholecystitis cases showed a markedly reduced total lysosome area and volume density of the lysosome compared with those of the acalculous chole-cystitis cases. The differences between the mucin secretary granules and lysosomes, according to the degree of severity of cholecystitis and the natures of gallstones, were statistically not significant.
Humans

The arthroscopic rotator cuff repair is now considered a mainstream technique with highly satisfactory clinical results. However, concerns remain regarding healing failures for large and massive tears and high revision rate. In recent decades, various repair strategies and construct configurations have been developed for rotator cuff repair with the understanding that many factors contribute to the structural integrity of the repaired construct. The focus of biomechanical test in arthroscopic repair has been on increasing fixation strength and restoration of the footprint contact characteristics to provide early rehabilitation and improve healing. These include repaired rotator cuff tendon-footprint motion, increased tendon-footprint contact area and pressure, and tissue quality of tendon and bone. Recent studies have shown that a transosseous tunnel technique provides improved contact area and pressure between rotator cuff tendon and insertion footprint, and the technique of using double rows of suture anchors to recreate the native footprint attachment has been recently described. The transosseous equivalent suture bridge technique has the highest contact pressure and fixation force. In this review, the biomechanical tests about repair techniques of rotator cuff tear will be reviewed and discussed.
Rehabilitation ; Rotator Cuff* ; Suture Anchors ; Sutures ; Tears* ; Tendons

The aims of this study were to assess the role of p53 overexpression in colorectal tumorigenesis and the association with clinicopathological features. The immunohistochemical results were semiquantitatively assessed. Expression of aberrant p53, tumor-suppressor gene product, was studied immunohistochemically using a monoclonal antibody in 11 nonneoplastic polyps, 19 tubular adenomas, 9 villous adenomas, and 48 colorectal carcinomas. Five out of 11 nonneoplastic polyps, 14 out of 19 tubular adenomas and one out of 9 villous adenomas expressed p53 protein. Seven out of 24 colorectal carcinomas without lymph node metastasis and 14 out of 24 colorectal carcinomas with lymph node metastsis expressed p53 protein. The case of more than 75% positivity of p53 in colorectal carcinoma with lymph node metastasis was seven out of 24, but that in lymph node negative group was two out of 24. In the colorectal carcinoma with lymph node metastasis group; metastatic intranodal neoplastic cells were expressed positively for p53 in 10 out of 14 cases and zero out of 10 cases in group of positive and negative expression of primary lesions, respectively. p53 protein expression was not significantly correlated with variable clinicopathologic features such as age, sex, tumor location, tumor size, differentiation and Dukes' stage. It is suggested that p53 protein overexpression could be a early event in pathogenesis of colon cancer but is not involved in progression of villous adenoma to adenocarcinoma. p53 overexpression seems to be involved in metastatic ability of colorectal carcinomas.
Adenoma ; Neoplasm Metastasis ; Cell Transformation, Neoplastic

A total 139 patients with Tetralogy of Fallot underwent total correction in the Department of Thoracic Surgery, Seoul university Hospital during 5 year-period from January 1974 to December 1978, with overall mortality of 16.5 percent. Operative mortality varied according to severity of the lesion, age of the patients, nature of the previous surgical treatment and presence or absence of an outflow tract across the pulmonic valve ring. Twenty-two patients died in the early postoperative period, one in the postoperative 15 th day and 116 patients were discharged from the hospital alive. There were 90 male patients and 49 female patients with male preponderance. And the age of the patients varied from 2.8 years to 31 years with average of 11.1 years. A patch of the right ventricular outflow tract and pulmonic annulus was required to relieve pulmonic stenosis in 104 patients. There were 20 deaths in group(19.2%) as compared to 3 deaths in the group of 35 patients who were treated without a patch. The electrocardiogram showed right ventricular hypertrophy in 101 cyanotic patients. The interventricular conduction was normal in 112 patients preoperatively. It was normal postoperatively in 22 among 112 patients in these group who were survived. Complete RBBB appeared at operation in 70 patients and 20 patients developed incomplete RBBB. Major causes of death were complete A-V block, Congestive Heart Failure and Bleeding in order.
Cause of Death ; Electrocardiography ; Female ; Heart Failure ; Hemorrhage ; Humans ; Hypertrophy, Right Ventricular ; Male ; Mortality ; Postoperative Period ; Pulmonary Valve Stenosis ; Seoul ; Tetralogy of Fallot* ; Thoracic Surgery

A total 139 patients with Tetralogy of Fallot underwent total correction in the Department of Thoracic Surgery, Seoul university Hospital during 5 year-period from January 1974 to December 1978, with overall mortality of 16.5 percent. Operative mortality varied according to severity of the lesion, age of the patients, nature of the previous surgical treatment and presence or absence of an outflow tract across the pulmonic valve ring. Twenty-two patients died in the early postoperative period, one in the postoperative 15 th day and 116 patients were discharged from the hospital alive. There were 90 male patients and 49 female patients with male preponderance. And the age of the patients varied from 2.8 years to 31 years with average of 11.1 years. A patch of the right ventricular outflow tract and pulmonic annulus was required to relieve pulmonic stenosis in 104 patients. There were 20 deaths in group(19.2%) as compared to 3 deaths in the group of 35 patients who were treated without a patch. The electrocardiogram showed right ventricular hypertrophy in 101 cyanotic patients. The interventricular conduction was normal in 112 patients preoperatively. It was normal postoperatively in 22 among 112 patients in these group who were survived. Complete RBBB appeared at operation in 70 patients and 20 patients developed incomplete RBBB. Major causes of death were complete A-V block, Congestive Heart Failure and Bleeding in order.
Cause of Death ; Electrocardiography ; Female ; Heart Failure ; Hemorrhage ; Humans ; Hypertrophy, Right Ventricular ; Male ; Mortality ; Postoperative Period ; Pulmonary Valve Stenosis ; Seoul ; Tetralogy of Fallot* ; Thoracic Surgery

Hospital transfusion service should be directed toward the optimization of transfusion therapy, but in practice the hospital transfusions, especially of fresh frozen plasma(FFP), were practiced inappropriately against the real need. So we evaluated the usage pattern of fresh frozen plasma in the Capital Armed Forces General Hostal during the period of January through December in 1994. And then, from 1995, after education of the clinician upon the basis of the survey in 1994, we regulated the use of FFP, by adapting the transfusion control program. We compared the result of 1995 to those of 1994, including the total used FFP number, the usage pattem in various disease and the combined use with other blood components. The results were as follow. 1. About 50% of total FFP was used inappropriately at 1994, and the main misuse was done to the patients who were suffering from renal disease and bum. About 14% of FFP usage combined with the packed RBCs was also seemed to be inappropriate in 1994. 2. In 1995, with the transfusion control program, there was 72% fall in the total hospital's usage of FFP and the misused conditions such as bum and nephrotic syndrome were virtually corrected. We concluded that the education, guideline and regulation by the director of the transfusion service could remarkably correct the inappropriate use of FFP without any special costs.
Arm ; Education ; Humans ; Nephrotic Syndrome ; Plasma*