Objective To summarize the clinical characteristics of Foix-Chavany-Marie syndrome.Methods The clinical,electroencephalography and imaging characteristics,as well as etiology,treatment and prognosis of 4 cases of Foix-Chavany-Marie syndrome were retrospectively evaluated,and relevant literature was reviewed to investigate its pathogenesis.Results All the 4 cases presented with hypersalivation,facial diplegia,dysarthria and dysphagia with autonomic-voluntary dissociation.Brain MRI showed bilateral cortical or subcortical lesions in the opercula and perisylvian areas.Three cases were secondary to encephalitis,and 1 case was related to perinatal hypoxic-ischemic encephalopathy.After administration of antiepileptic drugs,they were free of seizures.But all the other symptoms remained.Conclusions Autonomic-voluntary dissociation is a feature of Foix-Chavany-Marie syndrome.Most patients are due to bilateral structural or functional lesions between motor cortices and brain-stem cranial motor nuclei.The prognosis depends on the heterogeneous etiologies,such as encephalitis and cerebrovascular disease.

OBJECTIVE:To establish the quality method control of Jiufen spray,a percutaneous administration preparatio_n.METHODS:To determine the contents with TLCs method.The thin-layer plate was made of silica gel GF254. The spread out agent was chloroform-methanol-ammonia solution(4mol/L)(2∶6∶1). Dual wavelength scanning:strychnine and brucine:?s=254nm,?r=325nm;ephedrine:?s=500nm,?r=440nm.RESULTS:The within-day recoveries of strychnine,brucine and ephedrine were 99.048?2.388,99.532?0.958 and 99.504?0.555;the between-day recoveries were 98.796?1.058,99.58?0.476 and 99.42?0.838;the contents were(1.474?0.047)%,(1.372?0.052)%and(1.506?0.064)%(n=4) respectively.CONCLUSION:This method is stable and reliable and can be used for determination of the contents of this preparation.

AIM: To elevate the stability of the volatile oil in Jiufen Cataplasm (Semen strychni,Herba ephedrae,Oilbanum and Myrrha) with the help of inclusion with ?-Cyclodextrin. METHODS: The quality of the volatile oil in Jiufen Cataplasm before and after stability test was examined by thin layer chromatography and differential thermal analysis and thermogravimetric analysis. RESULTS: The combination of volatile oil and ?-cyclodextrin could form stable inclusion compound that helped constant in before and after inclusion. CONCLUSION: The process of enclosure with ?-CD can keep the active components of the volatile oil in Jiufen Cataplasm.

AIM To study the preparation and stability of sinomenine liposomes. METHODS Taking entrapment efficiency as index, different preparation methods, including thin film dispersion, reverse-phase evaporation, and aether injection were optimized. The leakage rate, the uptake rate and the storage temperature of the liposomes were studied at the same time. RESULTS The entrapment efficiency of reverse-phase evaporation was the lowest as 48.93 % . The entrapment efficiency of thin film dispersion and aether injection were near, as 68.91 T《B》 % and 66.57 % , respectively. CONCLUSION Thin film dispersion has higher entrapment efficiency and low command to the equipment. So it is suitable for the production of sinomenine liposomes on a large scale.

AIM: To study the stability on controlled release pellets of Ginkgolides. METHODS: According to the requirement of stability test of appendix XIXC of China Pharmacopoeia (2000 edition, Part Ⅱ), test for influencing factor, accelerated test and samples kept at room temperature were studied, applying similar factor analysis to appreciate the release stability. RESULTS: All the indexes accorded with the standard. CONCLUSION: Controlled release pellets have a good stability.

【Objective】To observe the influence of temperature and perfusate modifier on in-vitro mass transfer coefficient of microdialysis with sinomenine as a model drug.【Methods】The in-vitro relative recovery(RR) was assayed by HPLC at different temperatures and in perfusate including different concentrations of alcohol,and then the mass transfer coefficient was calculated.【Results】In-vitro RR increased with the temperature and the concentrations of alcohol,so did the mass transfer coefficient.【Conclusion】Temperature and alcohol at different concentrations have an effect on RR and mass transfer coefficient of microdialysis with sinomenine as a model drug.

AIM: The transdermal absorption data of sinomenine patch was fitted by grey model GM(1,1) and compared with other models. METHODS: The transdermal absorption experiment was carried out with Franz diffusion cell and the GM(1,1) was established by accumulation generation operator (AGO). RESULTS: The fitting precision was compared by using mean relative error and grey absolute correlation degree as evaluation criterion. CONCLUSION: The fitting precision of GM(1,1) is as high as acceptable.

Objective To evaluate the rat brain pharmacokinetics of tetramethylpyrazine phosphate (TMPP) after intranasal administration.Methods The pharmacokinetic behavior of TMPP in rat brain was investigated after intranasal or intravenous administration (10mg?kg-1) of TMPP.Brain samples were collected by intracerebral microdialysis.The concentration of TMPP in the sample was measured by high performance liquid chromatography (HPLC).Main pharmacokinetic parameters were calculated and analyzed by Das 2.0 pharmacokinetic software.Results The results showed that two administration methods were all fitted to one compartment model.The absorption of TMPP from the nasal cavity to brain was rapid.The concentration-time curve showed a prolonged duration of TMPP concentration in the brain after intranasal administration.AUC0-∞values were (698.26?122.59)?g?min?mL-1 in intranasal group and (446.25?107.44)?g?min?mL-1 in intravenous group,and the difference was significant between the two groups (P

Objective To investigate the clinical value and sonographic features of locally advanced cervical carcinoma using transvaginal color Doppler ultrasound(TVCDU). Methods A retrospctive analysis was carried on 2-D sonograms. And color Doppler flow imaging(CDFI) in 106 cases, confirmed by pathology and surgery. Results In locally advanced cervical carcinoma, the characteristerics on TVCDU were cervical enlargment, cervical masses accompanying with uteral effusion and extracervical infiltrative masses.The rich cervical blood flow signals demonstrated as called “fireball" sign. In early cervical carcinoma,the cervix showed no apparent cervical enlargment. The blood flow signals were increased.The average RI was 0.41. Conclusions TVCDU which is very valuable in judging the infiltration extent and in differential diagnosis preoperatively can be used as a routine examination method before locally advanced cervical carcinoma treatment.

Objective: To determine the condition of drying process for Radix Tripterygii Wilfordii extract. Methods: Under different dying temperature and time, both triptolide and triptophenolide extracted from extract of Radix Tripterygii Wilfordii were measured. Results: After Radix Tripterygii Wilfordi extract was dried for 48 hours at 80 ?C , loss of triptophenolide and triptolide was relatively low, but after dried more than 48 hours at 100 ?C , the content of triptophenolide and triptolide reduced by 15.0%～30.0%. Conclusion: Drying temperature for Radix Tripteryqii Wilfordii extract should be controlled under 80 ?C .