Chronic exposure to risk factors at the beginning stage of atherosclerosis development can damage endotheli?um and ultimately initiat endothelial dysfunction. Endothelial dysfunction is one of the major mechanisms in atherosclerosis development. High-density lipoprotein (HDL) is a lipoprotein with complicated function and is composed of a variety of pro?teins and lipids. Epidemiological studies showed an inverse correlation between HDL and atherosclerosis. The protective role of HDL on endothelium might related to its function in reversing cholesterol transport, reducing peripheral cholesterol accu?mulation, preventing foam cells formation, dilating vessels, antioxidant and anti-inflammation, all of which antagonize devel?opment of atherosclerosis. But HDL obtained from patients with cardiovascular disease which has known dysfunctional HDL may induce endothelial dysfunction. This review addresses the relationships between functional HDL or dysfunctional HDL with the endothelial function.

Objective:To observe the clinical efficacy of Shenfu Injection for the most gastric resection.Methods: ASA II-III patients undergoing elective surgery for 60 patients with subtotal gastrectomy, were divided into experimental group, control group randomly. The experimental group was divided into Shenfu group (A), the control group treated with dopamine (B). In the A group before induction of anesthesia with intravenous injection of 0.8ml/kg of Shenfu injection,and group B received balanced salt to maintain anesthesia, the disposal of the same. Patients were given dopamine, atropine and other vasoactive drugs, there were recorded before anesthesia(T0), immediately after tracheal intubation (T1), 30min after intubation (T2), 1h after intubation(T3) hemodynamics.Results: Compared with the control group, the experimental group canachieve hemodynamic stability time earlier, smaller influence on the fluctuation of blood pressure.Conclusion: Shenfu Injection on patients with coronary heart disease underwentsubtotal gastrectomy to improve the stability of circulation system.

Objective:to combine psychotherapy and medication in treatment of tension-type headache Method:84 patients with tension-type headache were randomly divided into study group (combining psychotherapy with medication) and control group (medication only) The psychotherapy was twice to three times a week, for 2 or 3 weeks and then follow up for at least 1 year Result:in the study group, the rate of improvement was 95%, that of marked improvement was 67%, were significantly higher than the counterparts in control group (were 69% and 38% respectively) Conclusion:combining psychotherapy with medication is more effective than medication only in treatment of tension-type headache

Objective To understand the inhibitory control in children with functional articulation disorder (FAD).Methods 30 children who met the criteria of FAD aged of 4-6 years were selected as the case group,and 30 normal speaking children matched in age were selected as the control group.The inhibitory control function were examined by handgame and day-night stroop task.The data were described as median (P25,P75) and the differences were compared between the two groups by rank test.Results The scores of handgame (4(3,5)) and day-night stroop task(13(11,16)) in case group were much inferior to those in control group (5 (4,5),15 (14,15)) (P＜0.05).Conclusion The inhibitory control of children with functional articulation disorder was much inferior to normal children.

[Objective]To study the injury mechanism of sacral plexus resulting from sacral zone-Ⅱ fractures of lateral compression.[Method]Six short-term(in a year) embalmed pelves were obtained from anatomic department of Hebei Medical University with preserving sacral plexus and resecting pubic symphysis,the models of sacral zone-Ⅱ fractures of lateral compression were produced.Quantitative analysis for fracture displacement was carried out to observe the characteristic and the mechanism of sacral plexus injury.Sacral plexus were replaced by proportional diameter silica gel pips fulled with contrast medium,experimental procedure was repeated under X-ray.The experimental data were analyzed by SPSS10.0 statistic software and the result was obtained.[Result]In lateral compression type sacral canal was closed and its volume reduced and small free fracture segment resulted in sacral plexus nerves oppressed,especially of L_5,Sland S_2.At the same time,the more overlapping of pubic symphsis,the more serious of compression.[Conclusion]Sacral plexus is conncted with the wall of pelvic cavity and fixed.Zone-Ⅱ sacral fracture is likely to damage sacral plexus.In lateral compression type of sacral fracture nerve injury is mainly compression injury which position is in nerve canal,especially of S_1,S_2.And L_5 can be crushed in fracture interspace to be damaged seriously.

Objective To discuss the relationship between C-reactive protein and prognosis of acute coronary syndrome. Methods C-reactive protein of 60 acute coronary syndrome patients was evaluated. The individuals were divided into two groups:One group with higher CRP level and another group with normal CRP level. The following-up duration was 6 months. After correct therapy, the morbidity of re-angina, arrhythmia, heart failure, re-infarction and cardiac death was compared. Results The morbidity of re-angina, arrhythmia, heart failure, re-infarction, cardiac death was 46.3%(19/41), 43.9%(18/41),9.76%(4/41),22.0%(9/41),7.32%(3/41)respectively in higher CRP level group; The morbidity of re-angina, arrhythmia, heart failure, re-infarction was 15.8%(3/19),10.5%(2/19), 5.3%(1/19),5.3%(1/19)respectively in normal CRP group and there was no cardiac death accident. There was significant different between the two groups. Conclusions CRP plays an important role in the onset of acute coronary syndrome, and its level is related with the higher morbidity of re-angina, arrhythmia, heart failure, re-infarction and cardiac death.

ObjectiveTo observe the effect of continuous passive motion (CPM) on postoperative functional rehabilitation in lower limb.Methods267 patients operated in lower limb were separated to CPM group (162 cases) and control group (105 cases). Patients of the CPM group used CPM device at early period post operation, and cases of the control group received instruction to exercise by themselves. The efficacy of two methods was evaluated.ResultsThe knee activity of affected extremity of CPM group at 10 day and 1 month was better than that of control group, as well as the rate of swelling extinction of affected extremity (P<0.05～0.01).ConclusionIt is propitious to functional rehabilitation of patients operated in lower limb that using CPM early post operation.

Prevention of infection by the human papillomavirus (HPV) has become a hot research topic since the relationship between the HPV and cervical cancer was confirmed. Persistent infection with HPV and early expression of proteins has an important role in the pathogenesis of cervical cancer. Vaccines that protect against four high-risk types of HPV (-6, -11, -16, -18) have been used worldwide. A bivalent vaccine (HPV-16 and -18) developed by Walvax is in clinical trials. This study reviews progress in ascertainment of the structure and function of the HPV genome, the molecular mechanism of carcinogenesis, and vaccines based on virus-like particles.
Animals ; Carcinogenesis ; Female ; Humans ; Papillomaviridae ; genetics ; immunology ; metabolism ; Papillomavirus Infections ; pathology ; prevention & control ; virology ; Papillomavirus Vaccines ; genetics ; immunology ; Uterine Cervical Neoplasms ; pathology ; prevention & control ; virology ; Viral Proteins ; genetics ; immunology ; metabolism

Objective To search for the anticancer active substance from Caesalpinia sappan wood extractions. Methods Crude extracts were extracted from Caesalpinia sappan wood with different solvents.Liquid chromatography was applied to analyze the content of each essential component in the extraction fractions. Trypan blue exclusion test was performed to detect the growth suppression rate of human bladder carcinoma cell line T24 treated by the extraction fractions at different time course (20,40,60,80,100 min).The main component positively correlated with the cell suppression rate was separated out using repeated chromatography, thus the anticancer active monomer was obtained, with purity over 98 ％. The chemical constitution was determined using NMR (nuclear magnetic resonance), mass spectrum and infrared spectrum methods. T24 cell line, human ovarian cancer cell line SKOV3, mice sarcoma S180 and hepatic carcinoma H22 cell were chosen as target subjects, with mitomycin, hydroxycamptothecin as positive control drug, the inhibitory activity of the monomer was tested by trypan blue chromophobia method. Results Among the extraction fractions, R12 has a positive correlation with the cell suppression rate (r100 min=0.941, P＜0.001).Brazilin is the key component in R12.The inhibition rate of brazilin could reach 90.89 ％,98.65 ％,99.82 ％ and 100.00 ％ on T24,SKOV3,S180 and H22 respectively in 40 min at the concentration of 1.2 mg/ml,and its effect is much superior to that of the control drug mitomycin and hydroxycamptothecin. Conclusion Brazilin is one of the essential anticancer principles in Caesalpinia sappan wood.

Objective To analyze the distribution and esophageal motility characteristics of patients with non obstructive dysphagia (NOD).Methods From June 2010 to June 2012,ninety seven patients with a sense of obstruction when swallowing were selected and patients with esophageal organic stenosis was excluded through endoscopic examination and upper gastrointestinal radiography.While nine healthy volunteers were recruited as healthy control.High-resolution esophageal manometry was performed with high-resolution multi-channel Netherlands CTD Synectics gastrointestinal function monitoring system (Pcpolygraf polysomnography recording system) and MMS digestive power detection system.The observation parameter included upper esophageal sphincter pressure (UESP),upper esophageal sphincter relaxation rate (UESRR),the length of the lower esophageal sphincter (LESL),lower esophageal sphincter pressure (LESP),intergrated relaxation pressure (IRP),lower esophageal sphincter relaxation rate (LESRR),esophageal subordinate segments pressure and esophageal effective peristalsis ratio.The rank sum test was performed for comparison between groups.Results Among 97 patients with NOD,the percentage of achalasia,nonspecific esophageal motor disorder andgastroesophageal reflux disease (GERD) was 41.2％ (40/97),39.2％ (38/97)and 19.6％(19/97),respectively.Among patients with nonspecific esophageal motor disorder,the percentage of abnormal peristalsis,absent peristalsis,normal pressure and distal esophegesl spasm was 39.5％(15/38),36.8％(14/38),15.8％(6/38) and 7.9％(3/38),respectively.The differences in lESL,LESP,LESRR,esophageal subordinate segments pressure and esophageal effective peristalsis ratio among achalasia,GERD,nonspecific esophageal motor disorder and healthy control were statistically significant (F 6.143,57.490,50.559,10.155 and 22.046,all P＜0.05).LESP oF patients with achalasia was higher than that of healthy control,however LESRR,esophageal subordinate segments pressure and esophageal effective peristalsis ratio were all lower than those of healthy control and the differences were statistically significant (F 2.276,11.113,-8.036 and -14.663,all P＜0.05).LESL and LESP of achalasia were both higher than those of GERD group,LESRR,esophageal subordinate segments pressure and esophageal effective peristalsis ratio were all lower than those of GERD group and the differences were statistically significant (F=4.325,15.983,-19.235,-3.410 and-4.351,all P＜0.05).LESL and LESP of achalasia group both were higher than those of nonspecific esophageal motor disorder group,LESRR and esophageal effective peristalsis ratio were both lower than those of GERD group and the differences were statistically significant (F=2.376,7.668,2.873 and-3.873,all P＜0.05).LESRR of GERDgroup was higher than that of healthy control group,LESL,LESP,esophageal subordinate segments pressure and esophageal effective peristalsis ratio were all lower than those of healthy control group and the differences were statistically significant (F=5.931,-2.483,-14.618,-3.071 and-4.516,all P＜0.05).LESL and LESP of GERD group were both lower than those of nonspecific esophageal motor disorder group,LESRR was higher than that of nonspecific esophageal motor disorder group and the differences were statistically significant (F =--2.113,6.578 and 10.979,all P ＜ 0.05).LESP,LESRR,esophageal subordinate segments pressure and esophageal effective peristalsis ratio of nonspecific esophageal motor disorder group were all lower than those of healthy control group and the differences were statistically significant (F=-6.313,-3.580,-3.511 and-8.150,all P＜0.05).IRP of 40 patients with achalasia were all beyond the normal range.Conclusions NOD mainly included achalasia,nonspecific esophageal motor disorder and GERD.The reduction of effective esophageal peristalsis may be an important pathophysiological mechanism of NOD.