Objective To analyze the acute left heart failure(ALHF) plasma brain natriuretic peptide levels and ECG characteristics,and to explore its evaluation of the ALHF prognosis.Methods To detect the content of rain natriuretic peptid in the plasma of acute attack of 76 cases ALHF patients after 6h,24h,72h,while the line ECG monitoring.The decline rate of brain natriuretic peptide,the QRS wave duration and QTc interval were calculated.According to the condition of ALHF patients discharged into prognosis ideal group and the poor prognosis group,the variation of the index in the two group were retrospectivly analyzed.Results Compared with the decline rate in 24h,the decline rate of brain natriuretic peptide,the QRS wave duration and QTc interval decreased significantly.Two groups at each time point plasma brain natriuretic peptide,the QRS wave duration,the rate of decline of QTc between groups were statistically different (all P ＜ 0.05).Conclusion The time points of plasma brain natriuretic peptide content,the QRS wave duration and the QTc interval change rate of ALHF the prognosis of patients with chnical predictive value.

Objective To approach the clinical manifestations of childhood cough variant asthma, and summarize the dingnosis and treatment experience. Methods Retroepective analyzed the clinical data of 49 children with cough variant asthma. Results In 49 children patients,male 27 cases,female 22 cases;Age:1 ～3 years old( 11 cases) ,4 ～6 years old(25 cases) ,7 ～ 12 years old( 13 cases) ;Duration:1 ～24 months;Incidence season:wintry spring (31 cases) ,summer(7 cases) ,autumn(11 cases). Diagnoeis:CAV was 8 cases,and 24 cases were misdiagnoeed as bronchitis, 11 cases were misdiagnosed as upper respiratory tract infection,3 cases were misdiagnosed as chronic pharyngitis,2 cases were misdiagnosed as sinusitis,1 case was misdiagnosed as bronchial foreign body. In 49 children patients,32 cases were significantly effective, 15 cases effective and 2 cases noneffective. Conclusion The clinical manifestations of CAV was noepecific,and miscdiagnosis rate was high. Effect of treatment with expansion bronchical and anti-infection methods was good.

Stenotrophomonas maltophilia(SMA) is a emerging opportunistic pathogen that can cause difficult-to-treat infections and exhibits significant degrees of poorly understood multidrug resistance,especially in irnmunocompromised patients.SMA is not an inherent virulent pathogen,but it can colonize in respiratorytract epithelial cells and surfaces of medical devices make it an important colonizer in hospitalized patients.Management of SMA infection is hampered because of its high-level intrinsic resistance to many antibiotics and the increasing occurrence of acquired resistance to the first-line drug such as co-trimoxazole.The prevention and treatment of SMA infection attract more and more attention in recent years.

Coagulase-negative staphylococci,especially staphylococcus epidermidis (SE) is on the surface of skin and mucous membrane of human,and because of its high frequency,especially in hospital,it is thought to be an important opportunistic pathogen.SE is the common cause of preterm infection,and it has relationship with immature brain.Epidemiology supports the relationship among preterm,infection and brain injury.SE could lead to brain injury through Toll-like receptor mediated inflammation.

Precocious puberty in children begins with the increased pulsatile secretion of the gonadotrophin-releasing hormone(GnRH)from hypothalamic.Recently,KISS1-GPR54 Was found to be a key factor to regulate the secretion of GnRH and the onset of puberty.Kisspeptin interacts with its receptor GPR54.which expressed on the hypothalamic GnRH neurons.and affects GnRH pulsatile release and the onset of puberty.GPR54 gene mutation causes the incidence of GnRH-dependent precocious puberty.

The innate immune system is critical to protect against microorganisms,but it is immature.Preterm newborn have to stay longer in NICU.They are vulnerable to infections.The common pathogen is coagulase-negative staphylococci which is the most cause of mortality for preterm newborn.So it is the key to understand the interaction between innate immune system of preterm newborn and pathogen.

Objectives:To investigate the effects of total parenteral nutrition (TPN) and somatostatin in the treatment of acute pancreatits. Methods: Patients were divided into two groups. Group A was patients treated from 1990 to 1994 with traditional non operative methods. Group B was patients treated from 1995 to 2000 with traditional methods plus both TPN and somatostatin. Results: In group B, morbidity, mortality and hospital stay were improved when compared with group A. The serum albumin concentration was below the normal at the beginning and was not different between the two groups. After the treatment of 15 days,the serum albumin concentration of group B was increased significantly and it remained almost the same in group A. Conclusions: Somatostatin and TPN can significantly improve the treatment effects of acute pancreatitis.

Melatonin has neuroprotective effect on hypoxic-ischemic brain damage(HIBD), which easily crosses the blood-brain barrier and plays neuroprotective role in reducing oxidative damage. Melatonin may be effective in preventing learing diabilities. It has been suggested that melatonin soporific effect is secondary to its ability to induce hypothermia. Neuroprotective effect of hypothmia has been proved. Howere, it is clear that hypothemia will not provide complete protection of HIBD and melatonin might augment protection of hypothemia in HIBD.

In recent years, ultrasonographic ultrasonographic ultrasonographic resolution level of gastrointestinal anatomy has been improved significantly due to perfection of ultrasonic instrument and development of ultrasound diagnostic technology. Currently, ultrasonographic ultrasonographic ultrasonography plays an effective role of evaluation of children's gastrointestinal obstruction diseases, especially congenital hypertrophic pyloric stenosis, gastroesophageal reflux, malrotation, midgut volvulus, superior mesenteric artery syndrome,duplication, intussusception, meconium peritonitis, meconium ileus, and congenital giant colon. The clinical manifestation and the ultrasonographic feature of all these diseases mentioned above are reviewed in this paper.

Objective To study the effect of evidence-based nursing care on medication compliance and rehabilitation effect of elderly patients with angina pectoris. Methods 89 cases of elderly people with angina pectoris were divided into the control group(43 cases )and the observation group(46 cases).The control group was treated with cardiology common nursing, the observation group received evidence-based nursing care of psychological nursing, life nursing and medication compliance. The medication compliance in each period of a year and rehabilitation effect after one year were analyzed and compared between the two groups. Results The medication compliance rate of the observation group was higher than the control group after 1, 2, 4weeks, 3, 6 months and 1 year, the total effective rate of rehabilitation was 91.3% in the observation group, also higher than the control group (62.8%)after 1 year. Conclusions Evidence-based nursing care can improve the medication compliance and the effect of rehabilitation of elderly patients with angina psctoris.