A total of 272 lots of immunoglobulin products was investigated, and the anti- body potency of measles was determined by hemogglutination inhibition test. The total antibody potencies of diphtheria, pertusis, rubella, epidemic hemorrhagic lever and titer of anti-HBs and anti-HAY were tested in some lots of immunoglobulin produced in recent years. The results provided a scien- tific basis for clinical use.

To collect the literatures which are the treatments of sjogren's syndrome with pulmonary fibrosis by traditional Chinese medicine. It is including the etiology and pathogenesis, specific prescription and medication, clinical proved recipe, single herb and experimental research to summarize the traditional Chinese medicine treatment of sjogren's syndrome with pulmonary interstitial fibrosis. After reviewing Literatures, the Chinese medicine to the sjogren's syndrome with pulmonary fibrosis has a vast developing prospect and deserves further study.

RORγt, an immune cell-specific isoform of RORγ( retinoic acid receptor-related orphan nuclear receptor gam-ma) , is a key transcription factor for the development of Th 17 cells both in human and mouse .RORγt is required for the induction of IL-17 transcription and for the manifestation of Th 17-dependent autoimmune diseases in mice .RORγt natural ligands are retinoic acid . RORγt is closely implicated in the pathology of numerous autoimmune diseases , infectious diseases and cancer .With the further re-searches about the role of RORγt, we will clarify the mechanism of RORγt in autoimmune diseases , which will provide new ideas to di-agnose and treat autoimmune diseases .

Objective To explore a high molluscicidal efficient method in special Oncomelania hupensis snail environments. Methods In 2005 and 2006,in large special environments(rubble creek beaches and seepage barren hills with snails),the me-chanical soil-buried method(excavator digging to bury deep snails)and manual soil-buried method were used respectively,and the results were compared for the cost-effectiveness. Results With the mechanical soil-buried method in 2006,the investment was 0.78 yuan/m2,and the compression rate of snail areas was 100%;with the manual soil-buried method in 2005,the investment was 1.34 yuan/m2,and the compression rate of snail areas was 20.26%. The former was much better than the latter. Conclusion In the large special environments with snails,the mechanical soil-buried method is superior to manual soil-buried method.

Objective To evaluate the molluscicidal effect of black plastic film combined with carbon amide. Methods In Jiangdong Town Jinhua City the field with Oncomelania hupensis in the history was selected as experimental area and divided into 3 groups Group One was administered with black plastic film combined with carbon amide Group Two was administered with simple black plastic film and Group Three was a control group. Results On the 3rd 7th 15th 20th and 30th day after the experiment the mortality rates of O. hupensis of Group One were 86.0% 88.0% 100% 100%and 100%respectively which were significantly higher than those of the control group all P<0.05 . The differences of mortality rates between Group One and Group Two were statistically significant on the 3rd and 7th day after the experiment Group One was superior to Group Two . Conclusion The black plastic film combined with carbon amide can improve the molluscicidal effect.

OBJECTIVE: To observe changes of serum Th1/Th2 cytokines and IgE of rats with experimental allergic rhinitis (AR) treating with Scoparone (20 ml/kg, the concentration is 168 mg/L). METHOD: Forty male SD rats were randomly divided into 4 groups : group NC, group AR, group Sco, group Dxm. The rats were sensitized with OVA and were then treated with Scoparone, during the treatment, the behaviors were observed and the change in nasal mucosa were recorded. The level of serum cytokines IFN-gamma, IL-4, IL-5 and IgE were determined by ELISA. RESULTS: The behavior scores of group Sco were significantly lower than those of group AR, the difference was statistically significant (P < 0.01). Comparing to group Dxm and group NC respectively, the difference was not statistically significant (P > 0.05). The nasal inflammation of group Sco was significantly less than that of group AR. The level of serum IFN-gamma of group Sco was significantly higher than that of group AR, while the levels of serum IgE, IL4, IL-5 of group Sco were significantly lower (P < 0.01). There were no significantly difference between group Sco and group NC, group Dxm, the difference was not statistically significant (P > 0.05). CONCLUSION Scoparone is highly effective in treating allergic rhinitis by regulating the expression of Th1/Th2 cytokines and IgE.
Animals ; Coumarins ; pharmacology ; Disease Models, Animal ; Immunoglobulin E ; blood ; Interferon-gamma ; blood ; Interleukin-4 ; blood ; Interleukin-5 ; blood ; Male ; Rats ; Rats, Sprague-Dawley ; Rhinitis, Allergic ; Rhinitis, Allergic, Perennial ; drug therapy ; Th1-Th2 Balance ; drug effects

Objective To investigate the effect of continued nursing on postoperative outcomes of discharged patients with chronic suppurative otitis media.Methods Toally 198 discharged patients were randomized into the control group (n=98) and the observation group (n=100).The patients in both groups received normal health education and additionally the continued nursing was used in the observation group for health education by way of phone call follow-up,on-the-spot consultation and QQ consultation.The mastery of related knowledge and skills,incidence of secondary tympanic membrane and readmission rate were compared.Results Six months after discharge,the observation group was significantly better than those the control group in the mastery of related knowledge and skills (P＜0.05).The incidence of secondary tympanic membrane perforation was not statistically significant between the groups(P＞ 0.05).The readmission rate at the second week and the third week between the two groups had no statistically significant difference (P＞ 0.05).However,the readmission rate at the first,second,third and sixth month were statistically different (P＜0.05).Conclusion Continued nursing to the postoperative discharged patients with chronic suppurative otitis media can improve the follow-up rate after discharge and self-nursing capacity,and as a result promote their recovery.

Objective To achieve arabinose-controlled expression of HtrA strain and detect the expression of HtrA protein.Methods Arabinose promoter with htrA100 was amplified from pACD-htrA vector by PCR and cloned into pGP704 vector.Then, Shigella flexneri 2a strain 301 was transferred with the recombinant plasmid pGD-htrA and an AraC-expression vector .The expressions of HtrA in whole-cell and periplasmic space were detected by Western blotting .Results The suicide plasmid-mediated homologous recombinant vector and the inducible HtrA expression strain were successfully constructed.Without arabinose,HtrA protein was hardly detected ,but in the presense of arabinose , HtrA protein could be detected in whole-cell lysate and in periplasmic space lysate by Western blot .Conclusion Homologous recombination using suicide plasmid can significantly knock down the expression of HtrA protein .After being induced with arabinose , HtrA protein can be expressed normally .

Objective To explore the mediating role of intelligence in the relationship between in-formation processing speed and numerical magnitude processing of hearing-impaired children. Methods A survey was conducted among 249 hearing-impaired children by using tests of Choice Reaction Time,Numero-sity Comparison,and Raven's Progressive Matrices( simplified version). Results (1) The accurate rate of information processing speed(0. 89±0. 18)of hearing-impaired children was positively correlated with that of numerical magnitude processing(0. 65±0. 15)and intelligence(11. 83±10. 34)(r=0. 165,0. 263,both P<0. 01). The reaction time of information processing speed was negatively correlated with those of numerical mag-nitude processing and intelligence(r=-0. 164,-0. 197,both P<0. 05). And there was significant positive correlation between intelligence and numerical magnitude processing (accurate rate and reaction time ) (r=0. 269,0. 140,both P<0. 05). ( 2) The accurate rate of information processing speed significantly predicted that of numerical magnitude processing in hearing-impaired children( β=0. 17,t=2. 64,both P<0. 01). The reaction time of information processing speed significantly predicted that of numerical magnitude processing in hearing-impaired children(β=-0. 16,t=-2. 61,both P<0. 05). And intelligence played a complete medi-ating role in this relationship and the moderating effect were 36. 71% and 31. 25%. Conclusion Information processing speed has indirect effects on numerical magnitude processing through intelligence in hearing-im-paired children.

Objective To observe the expression of the polysialic acid neural cell adhesion molecule ( PSA-NCAM) in the hippocampus of rats after exposure to low intensity ( 16 Hz,90 dB) infrasound for different periods.Methods One hundred and twenty male Sprague-Dawley rats were randomly divided into infrasound exposure and normal groups.The exposure group was tjem further divided into 1 day,7 days,14 days and 21 days exposure groups.After exposure,the rats' brains were removed and an immunohistochemical technique was used to observe the expression of PSA-NCAM in the hippocampus after 1,7,14 or 21 days of exposure. Methods The expression of PSA-NCAM had increased significantly after exposure for 7 days. It peaked at 14 days,then had decreased by 21 days,but always remaining higher than in the normal group.After the infrasound exposure had ended,the expression of PSA-NCAM demonstrated a tendency of decrease over time,and the least was on the 21st day.The largest decrease was observed in the 14 days exposure groups. Conclusion 16 Hz,90 dB infrasound can increase the expression of PSA-NCAM in the hippocampus,at least in rats.This suggests that low intensity infrasound might initiate recovery of an injured central nervous system.Migration of neural stem cells may aid in the repair of neural injuries resulted from infrasound exposure.