OBJECTIVE: To study the characteristics and regularity of adverse drug reactions (ADR) occurred in our hospital. METHODS: A total of 241 ADR cases occurred in our hospital form Jan. 2006 to Jun. 2009 were analyzed statistically in respect of patients’ status, category of drug, route of administration, organs and system involved in ADR and clinical manifestations. RESULTS: Of the total 241 ADR cases, 69.71%ADR cases were induced by antibacterials. 71.78% ADR cases were induced via intravenous administration. ADR mainly appeared as lesion of skin and appendants (50.92%). CONCLUSION: It is necessary to intervene and guide clinical use of drug, strengthen the monitoring of ADR and reduce the occurrences of ADR.

Objective To explore risk factors for asthma children in Urumqi aged 0-14 years old through the epidemiological survey data.Methods By cluster sampling method,totally 11 939 children were investigated.There were 148 cases of asthma,by using case-control study,the risk factors for asthma were analyzed.Results The total asthma morbidity rate of childhood asthma (aged 0-14 years old) in Urumqi(1.24％,148/11 939 cases) was significantly lower than that of national city incidence (3.02％) based on the third-time national survey;the prevalence rate was obviously rising compared with the region in 2000 (0.61％) and 1990 (0.40％).The prevalence of asthma in male and female children was 1.72％ (104/6 047 cases) and 0.75％ (44/5 892 cases),respectively (x2 =23.081,P ＜0.001).Preschool children had the highest prevalence of asthma (1.33％,36/2 705 cases),which was slightly higher than that of school-age children (1.29％,86/6 690 cases) and that of the infants (1.02％,26/2 544 cases).The prevalence in Han children (1.36％,121/8 895 cases) was higher than that of the minority children (0.89％,27/3 044 cases)(x2 =4.150,P ＜ 0.05).The uni-variate Logistic regression analysis showed that there were 16 significant factors that related to asthma;bv multivariate Logistic regression analysis,the family history of allergies,allergic rhinitis,food allergy history,use of antibiotics and passive smoking were all risk factors associated with childhood asthma.Conclusions The asthma prevalence is significantly different in genders,ages,Han nationality and minority.Active avoidance of risk factors for asthma in children are of great significance in the prevention and control of children asthma.

OBJECTIVEThis study aims to investigate the feasibility of tongue reconstruction by a rectus abdominis musculoperitoneal flap with neurovascular pedicled in a canine model.

METHODSTwelve Beagle dogs were enrolled to the experiment. The animals were randomly divided into thee groups, two of which (group A and B) had nerve anastomosis. The left sides were experimental sides, whereas the right sides were control sides. Twelve weeks after operation, electrophysiological test was performed to detect hypoglossal nerve latency amplitude and conduction velocity as well as to evaluate the reinnervation of the rectus abdominis musculoperitoneal flap.

RESULTSAmong the 12 Beagle dogs, nine animal tongue reconstruction models by rectus abdominis musculoperitoneal flap with neurovascular pedicled were successful, whereas one male Beagle dog died from ventral hemia 3 d after the operation, two female rectus peritoneal flaps were abandoned because their arterial anatomy differed from the male, which was not ideal. Hypoglossal nerve conduction velocity of group A and B were restored to the normal side of the 40%, 30%.

CONCLUSIONAnimal models of tongue reconstruction can be established by a rectus abdominis musculoperitoneal flap with neurovascular pedicled in Beagle dogs. Denervated rectus abdominis musculoperitoneal flap can regain hypoglossal nerve innervation. Hypoglossal nerve functions partly recover.

Animals ; Disease Models, Animal ; Dogs ; Reconstructive Surgical Procedures ; Rectus Abdominis ; Surgical Flaps ; Tongue ; surgery

OBJECTIVE: Obstructive sleep apnea hypopnea syndrome (OSAHS) and non-alcoholic fatty liver disease (NAFLD) are both strongly associated with obesity. Whether OSAHS is an independent risk factor for liver injury or not is uncertain. To assess the hypothesis that OSAHS is associated with liver injury independent of obesity. METHOD: One hundred and thirty children with OSAHS and 77 children with primary snoring(PS) were enrolled. Polysomnography was performed. Body mass index (BMI), liver function tests, serum lipids, fasting plasma glucose (FPG), and insulin (INS) were measured. RESULT: Seventeen children of OSAHS had elevated serum aminotransferase levels,while only 2 children of non-OSAHS had elevated serum aminotransferase in healthy control group (chi2 = 5.18, P < 0.05; OR = 5.64 CI 1.27-24.97). Fifteen children of obese had elevated serum aminotransferase levels, while only 4 children had elevated serum aminotransferase in non-obese group (chi2 = 4.58, P < 0.05; (OR = 1.97 CI 1.06-3.67). Seventy cases of obese children, 15 cases of elevated aminotransferase levels (21.4%), namely fatty liver patients, of these children, 14 had OSAHS (93.3%). In contrast, OSAHS was present in only 67.3% of obese children without elevated aminotransferase. CONCLUSION OSAHS may be a risk factor for liver injury independent of obesity; Increased liver enzyme levels are frequently found in obese snoring children, particularly among those with OSAHS.
Adolescent ; Blood Glucose ; analysis ; Body Mass Index ; Case-Control Studies ; Child ; Fatty Liver ; blood ; enzymology ; Female ; Humans ; Insulin ; blood ; Male ; Obesity ; blood ; complications ; Risk Factors ; Sleep Apnea, Obstructive ; blood ; complications ; Snoring ; blood ; Transaminases ; blood