1.Fingerprint and Quality Evaluation of Apocynum Venetum Leaves
China Pharmacy 2005;0(24):-
OBJECTIVE:To establish the HPLC fingerprints of Apocynum Venetum leaves, determine the content of Quercetin in the sample and evaluate the variety and quality of commercial Apocynum Venetum leaves. METHODS: Quercetin was separated on Zorbarx-C18(250 mm?4.6 mm, 5 ?m),and the mobile phase consisted of methanol and 0.4% H3PO4(gradient elution) at a flow rate of 0.9 mL?min-1 with the detective wavelength set at 360 nm. RESULTS: The precision of Quercetin was satisfactory(RSD=0.21%,n=6),and the solution of Apocynum Venetum leaves was reproducible and stable within 10 hours. CONCLUSION: This study serves as a scientific basis for the identification and quality evalution of Apocynum Venetum leaves.
2.Optimization of the Preparation Technology of Baicalein Sustained Release Microspheres by Central Composite Design
China Pharmacy 2007;0(30):-
OBJECTIVE:To optimize the preparation technology of Baicalein sustained release microspheres.METHODS:The microspheres containing baicalein were prepared using solvent evaporation technique.Multiple linear regression equation and quadratic polynomial equation were fitted respectively with the mass ratio of the matrix materials,sodium dodecyl sulfate(SDS)concentration in water phase and drug content as independent variables,and with the accumulative drug release percentage at 2,12 and 24 h(Y1,Y2,Y3)as dependent variables.RESULTS:The baicalein sustained release microspheres prepared in accordance with the above technology were spherical and even.The optimized technical conditions were as follows:the drug content was 25%;the ratio of the matrix materials was 3.5;SDS concentration was 0.08%;Y1,Y2 and Y3 were 21.05%,55.70% and 87.75%,respectively.All the three equations fitted using quadratic polynomial equations achieved good fitting results.CONCLUSION:Central composite design is convenient to use and it has satisfactory predictability thus deserving popularization.
3.Octreotide for advanced hepatocellular carcinoma:Meta-analysis of randomized controlled trials
Chinese Journal of Postgraduates of Medicine 2010;33(16):28-31
Objective To evaluate the effect of octreotide on the survival of patients with advanced hepatocellular carcinoma(HCC).Methods Electronic databases searches were conducted.Meta-analysis of all randomized controlled trials (RCTs) comparing octreotide versus placebo or no treatment was performed.Results Five RCTs including 579 patients with HCC wers assessed.Meta-analysis of the five studies showed that octreotide had no significant effect on the 6,12 and 24 months survival rates of the patients(6months:OR=1.69,95%CI 0.89-3.21,P=0.11;12 months:OR=2.41,95%CI 0.83-6.93,P=0.10;24months:OR=0.58,95%CI 0.28-1.17,P=0.13).To perform the sensitivity analysis,the blank study,the trial detecting somatostatin receptor expression,the study with short survival or the two trials with short follow-up intervals were excluded,and the results also showed that the octreotide treatment had no significant effect on the 6 and 12 months survival rates.A sensitivity analysis based on two trials indicated that the 24months survival rate of the octreotide group was even lower than that of the control group(OR=0.51,95% CI0.27-0.98,P=0.04).Conclusions This Meta-analysis demonstrates that octreotide could not improve the survival of patients with advanced HCC.The administration of octreotide should not be recommended for the treatment of advaneed HCC.
4.Diagnosis,treatment and prognosis of fetal hydrocephalus
Chinese Journal of Applied Clinical Pediatrics 2016;(2):89-92
Fetal hydrocephalus is a kind of congenital malformation,which is characterized by the enlargement of the ventricular system and the obstruction of cerebrospinal fluid.It is not accompanied by a primary brain atrophy,with or without the increase of head circumference.Early diagnosis and early treatment is very important.Without the timely inter-vention,most of the patients will die during the perinatal and infant period,and even the survivors often suffer from cere-bral palsy and mental retardation.However,the long -term prognosis and clinical course of patients with hydrocephalus is not yet fully understood.There is controversy on the factors which influence the long -term outcome,such as the timing of diagnosis of hydrocephalus,the severity of ventricular dilatation,the basic disease and accompanying anomalies.So,should establish comprehensive protocols to avoid and decrease fetal hydrocephalus,as well as pay attention to the clinicopatho-logical research,prenatal diagnosis,perinatal management and early treatment of fetal hydrocephalus.
5.STUDIES ON POLYSACCHARIDE FROM SARGASSUM THUN-BERGII FOR ITS ABILITY TO SCAVENGE ACTIVE OXYGEN SPECIES Ⅱ On Effect of Far Ultraviolet Radiation on Antioxidation of Polysaccharides
Chinese Journal of Marine Drugs 1994;0(03):-
The effect of far ultraviolet radiation on scavenging active oxygen radiacal of polysaccharides from Sargassum thvnbergii and Sargassum kvrneri was studied. The results showed that the scavenging superoxide an ion radiacal levels of two polysaccharides were obviously decreased after 24h by UVc radiation,but the inhibition of the peroxidization of PU-FA was very prominent.The changes of IR spectra before and after far ultraviolet radiation on the two polysac-charide were also studied by differential scanning calorimetry(DSC)and infrared absorption spectroscopy(IR)
6.Evaluation of the therapies for neonatal posthaemorrhagic hydrocephalus
Journal of Clinical Pediatrics 2014;(3):201-205
Although the percentage of preterm infants developing intraventricular haemorrhage (IVH) has been greatly re-duced in the past three decades, increased survival of extremely preterms has meant that severe IVH with subsequent posthae-morrhagic hydrocephalus is still one of the serious unsolved problems for managements of preterms. Therapeutic interventions for posthaemorrhagic hydrocephalus include serial lumbar punctures, repeated aspiration through a ventricular access device, ventriculoperitoneal shunting, drainage, irrigation and fibrinolytic therapy, diuretic therapy treatment to reduce cerebrospinal fluid production, intraventricular fibrinolytic therapy, etc. This review summarizes the current concepts on the pathophysiology, inter-vention indications, and the effectiveness and safety of different interventions of subsequent posthaemorrhagic hydrocephalus.
7.Establishment of Central Sterilization Supply Department Green Pass Way:Thinking and Practice
Chinese Journal of Nosocomiology 2009;0(18):-
OBJECTIVE Discussing the central sterilization and supply department (CSSD) working model,to change CSSD serving concept and to improve clinical satisfaction degree for CSSD. METHODS Nurse in charge set forth an aim to establish CSSD green pass way in 2007. CSSD applied the meticulous administration,prolonged its serving time,assigned trained workers to deliver emergency articles,and prepared the individual packets to meet clinical special needs. RESULTS Clinical satisfaction degree was increased from 58.0% in 2005 to 95.1%in 2008,and complains were decreased from 15 times in 2005 to zero in 2008 (P
8.The clinical application of mesiolization of molars by segmental arch technique
Lijun YU ; Huanmiao YU ; Xiande ZHOU
Journal of Practical Stomatology 2009;25(6):904-905
The first molar of youth is often extracted for seriously caries or without long term good effect after therapy because the first molar is often misunderstood as deciduous tooth by parents and therefore it is regarded as unnecessary to treat. For such young patients, the corresponding ipsilateral first molar caries while third molars (or germ) existing with crown well-developed,we can exact the first molar and move the second molar by segmental arch technique. In this way, we can quickly shift the second molar to the desired location, increases the efficiency and reduce both dental movement and period of treatment.
9.Isolation of hepatocytes:a review of current methods
Fulong MIAO ; Zeli YU ; Lijun ZHANG
International Journal of Surgery 2009;36(6):407-409
Due to the increasing use of hepatoeytes,the demand of hepatoeytes is increasing consistently in basic clinical research.The application of rational and efficient method of hepatoeyte isolation is a prereq-uisite for its application.At present,there are many methods of hepatoeyte isolation.This review summarizes the latest progress on them.
10.Ilaprazole in the treatment of duodenal ulcer:a Meta analysis
Lijun YU ; Weiping HUANG ; Junling HAN
Chinese Journal of Postgraduates of Medicine 2011;34(31):15-17
Objective To systematically review the efficacy of ilaprazole in duodenal ulcer by Meta analysis.Methods Randomized controlled trial (RCT) comparing ilaprazole with other proton pump inhibitors in duodenal ulcer were searohed for Meta analysis.Results Six RCT met the inclusion criteria and 1319 patients were included.Meta analysis showed that the healing rate at 4-week in the dose of ilaprazole 10 mg/d was higher than that in control group [ 89.1% (591/663 ) vs.86.4% (426/493) ],but there was no significant difference (P> 0.05 ).When including high-quality literature,English literature,Chinese literature,or the literature using omeprazole as control,there was no significant difference either (P > 0.05 ).The adverse rate in the two groups had no significant difference [ 9.7% (64/663) vs.12.6% (62/493)] (P >0.05 ).The 4-week healing rate between the doses of ilaprazole 5 mg/d and 10 mg/d had no significant difference [84.7%(138/163) vs.84.0%(131/156)](P>0.05).Conclusions Ilaprazole has high healing rate for duodenal ulcer,with low adverse rate.The effect of the dose ot5 mg/d is comparable to 10 mg/d.