Objective To investigate the psychological state and its correlation factors of family members of elderly cancer patients. Methods A total of 76 family members of elderly cancer patients were investigated with questionnaires with Zung's self-rating anxiety scale (SAS) and self-rating depression scale (SDS). Their psychological state and its correlation factors were analyzed. Results Incidence rate of anxiety of elderly cancer patients' family members was 52.63%, and incidence rate of depression was 46.05%. The mean standard score of SAS and SDS of elderly cancer patients' family members were both significantly higher than domestic norm. Difference of family member's gender, ways to pay health care fee, pain degree and disease condition led to different SAS and SDS score. Conclusions Family members of elderly cancer patients possessed different degree of psychological obstacle which related with multiple factors. Medical staff should not only think highly of patients' psychological state, but also their family members'. And meanwhile they should take corresponding strategy to reduce the incidence rate of anxiety and depression state in those family members.

This report presents two cases of unilateral acute labyrinth loss resulted from injury,each showing delay in compensation possibly due to long-term administration of diazepam.The recent literature of the effects of the drugs onyestibular compensation is reviewed.The vestibular"suppressants"property of diazepam delays compensation when used on a long-term basis.However,it might be useful in controlling vege- tative symptoms and thereby possibly facilitate compensation when used on a short- tern basis.

Chemotherapy plays a significant role in cancer therapy,but chemotherapy-induced nausea and vomiting(CINV)common happened and affects patients satisfaction with treatment.With the development ot physiology on emesis,the new antiemetics such as 5-HT3 receptor antagonist(5-HT3RA),Aprepitant and Olanzapine greatly improved the control of CINV,the guidelines for antiemeties were deftned.Research progress of antiemetics was summarized.

Background Retinol binding protein 4(RBP4) is a novel adipokine which has been related with insulin resistance.Objective To test the hypothesis that telmisartan improves glucose and lipid metabolism may be associated with inhibiting serum RBP4 and phosphoenolpyruvate carboxykinase activity in liver.Methods Thirty wistar male rats were received high fat diet to establish metabolic syndrome model and randomly to receive telmisartan [5 mg/(kg?d),n=8] or pioglitazone [20 mg/(kg?d),n=8] for 8 weeks or high-fat diet placebo(n=10).Plasma triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),fasting plasma glucose(FPG),fasting plasma insulin,serum RBP4,and phosphoenolpyruvate carboxykinase specific enzyme activity in liver(PEPCK) were determined.Results Telmisartan improved insulin resistance and the disorders of glucose and lipid metabolism in diet-induced insulin resistance rats [HOMA-IR,telmisartan group(3.4?1.2) vs high-fat diet group:(8.3?1.1),P

Objective To investigate protective of umbilical cord-mesenchymal stem cells ( UC-MSC ) on idiopathic pulmonary fibrosis ( IPF ) experimental mode was induced by bleomycin in mice .Methods IPF experimental mode induced by bleomycin with intratracheal injection , and then the fourth generation UC-MSC was injected in caudal vein.The lung tissues were obtained to evaluate the influence of UC-MSC on IPF by the observation of histological evaluation(HE) and Masson staining, the detection content of hydroxyprine(HYP), superoxyde dismutase(SOD) and malonaldehyde ( MDA) .Results The HE and Masson staining showed that bleomycin +UC-MSC group could alleviate inflammatory cell infiltration and pulmonary interstitial collagen deposition.bleomycin+UC-MSC group could decline the content of HYP(P<0.01), MDA(P<0.05) and improve the content of SOD(P<0.01)compared with bleomycin group.Conclusion UC-MSC exhibits an protective effect on IPF experimental mode induced by bleomycin in mice.

Objective To investigate the role of psychological intervention on cosmetic plastic surgery.Methods 600 cosmetic plastic surgery were collected from cosmetic plastic surgery of Jinan Military General Hospital,then randomly divided into control group(n=300) and study group (n=300) according to odd and even on the first visit.Conventional treatmentand care were applied to control group before,during and after operation.For study group,in addition to giving a general treatment and care,preoperative consultation talks were given to understand the beauty of the psychological characteristics,and motivations and expectations were given to adjust;music and psychological support were presented intraoperative; rehabilitation guidance were given after operation.Symptom checklist 90( SCL-90),general psychological problems of body image self-rating scale and postoperative satisfaction scale were used to assess the the mental state,body image question and satisfaction of plastic surgery.Results Before intervention,the scores of SCL-90 and the general body image self-rating scale were ( 187.5 ±52.61 ),(12.1 ± 2.2) in study group and (179.87 ± 53.33 ),(12.9 ± 2.0) in control group,there was no significant differences(P＞0.05).After intervention,the scores of SCL-90 and the general body image self-rating scale ( 159.6 ± 31.3 ),(5.6 ± 0.5 ) in study group were lower than those in control group ( 167.4 ± 38.2 ),( 6.2 ±1.1 )(P ＜ 0.01 ).Before and after treatment,50％ reduced rate of 26％,25％ reduced rate of 41.6％,body-negative rate of 97.1％,overall satisfaction rate of 89％ of surgery in study group were higher than 14％,27.6％,84.3％ and 53.67％ in the control group,the differences were significant (P＜0.01 ).Conclusion Psychological interventions can improve the psychological state,body image disturbance and operative satisfaction in cosmetic plastic surgery.Psychological interventions should pay more attention to irrmprove the efficacy of cosmetic plastic surgery.

Objective To discuss the application of insulation blanket in the esophageal cancer radical surgery.Methods 40 cases of esophageal carcinoma patients were divided into two groups at random,20 cases involved in the control group (non-use of insulation blankets) and 20 cases in the experimental group (use of thermal insulation blanket).The changes in body temperature of all patients were monitored with nasopharyngeal temperature probe and analyzed in statistics.Results Compared to the control group,the body temperatures of the experimental group were higher.By heating with insulation blanket,the body temperatures were increased obviously in 30 minutes after entering the operation room,but no significant difference appeared at different time points after 30 minutes.Conclusions In radical surgery of esophageal cancer,the use of blanket insulation is an effective way to maintain a constant body temperature of patients and reduce post-operative complications,and promote early recovery of patients.

Objective To explore the clinical effect of fleabanein in treatment of acute cerebral infarction.Methods 42 cases were randomly divided into treatment group(22 cases) and control group(20 cases).Treament group is given iv.fleabanein and compared with control group.Results The cured and effective cases of treatment group is 18 cases,that of control group is 8 cases,there is obvious difference(P < 0.05).Conclusion Fleabanein has better effect on acute cerebral infarction.

Currently, the commonly used diagnostic markers have the shortcomings of lower sensitivity or specificity in the early diagnosis of cardio-cerebrovascular diseases. Therefore, it needs to use the novel specific biochemical markers for the early diagnosis arid treatment, so as to decrease the high mortality and disability caused by cardio-cerebrovascular events. Fatty acid-binding proteins (FABPs) are a family of low-molecular-weight intracellular lipid-binding proteins. They are divided into 9 different subtypes, including the liver-, intestinal-, heart-, brain-, adipocyte-, skin-, ileal-, myelin-, and testis-subtype. Their primary function is to transport long-chain fatty acids into the cells, and thus regulate intracellular lipid metabolism. The structures of all FABP subtypes are similar, inclusive of two α2 helices arid one β2 fold structure. Among them, the sensitivities and specificities of the heart- and brain-subtype FABPs are higher in the early diagnosis of cardio-cerebrovascular diseases. It is promising to become the novel markers in the early diagnosis of cardio-cerebrovascular diseases.

ObjectiveTo compare the levels and locations of metalloprotionase-2（MMP-2），collagen types Ⅰ and Ⅵ in keratoconus and normal human corneas．MethodsAn immunoperoxidase and indirect immunofluorescent technique were used to visualize the presence of collagen types Ⅰ， Ⅵ and MMP-2．The immunohistochemical staining was further analyzed and the intensity of reaction products was measured with an Image-processing system．ResultsCollagen type Ⅰ was demonstrated immunohistochemicall and indirect immunofluorescent technique in the bowman and stroma layers；collagen type Ⅵ was in epithelium basement，bowman，stroma and descement layers；MMP-2 was in epithelium，stroma and endothelium of all corneal sections．Compared with normal control specimens，the staining intensity of collagen types Ⅰ and Ⅵ was similar，while MMP-2 was markly increased．ConclusionsKeratoconus contained an increased level of MMP-2 and similar of collagen levels．These results lead further support to the hypothesis that degradation processes may be aberrant in keratoconus．