Objective:To explore the role of multiple mediating effects on scientific research creativity of nursing postgraduates.Methods:In the study, 127 nursing postgraduates from three affliated hospitals of Chongqing Medical University were selected by convenience sampling. The investigation scale included general information questionnaire, tutor support scale, nursing scientific research self-efficacy scale, autonomy motivation scale and scientific research creativity scale. The questionnaire of nursing postgraduates was collected through the Sojump platform, and the data of 127 postgraduates were effectively collected in strict accordance with the inclusion and exclusion criteria. The difference analysis and correlation analysis were carried out by SPSS.Results:The correlation analysis showed that nursing postgraduates' scientific research self-efficacy and autonomy motivation were significantly positively correlated with tutor support and scientific research creativity ( P<0.05). Multiple linear hierarchical regression analysis showed that nursing research self-efficacy and autonomy motivation played a partial mediating role between tutor support and scientific research creativity ( P<0.05), in which the mediating role explained 13.1% and 4.2% of the variation respectively. The structural equation model further verified the role of multiple mediating effects on the scientific research creativity of nursing postgraduates. Conclusion:The scientific research creativity of nursing postgraduates is closely related to tutor support, scientific research self-efficacy and autonomy motivation. Tutors can enhance nursing postgraduates' scientific research self-efficacy and autonomy motivation by improving the level of tutor support, so as to improve the scientific research creativity of postgraduates.

Objective To investigate the risk factors for pulmonary infection in patients with acute-on-chronic liver failure(ACLF),and to establish a predictive model.Methods A retrospective analysis was performed for 585 ACLF patients who were admitted to Department of Infectious Diseases,The Second Affiliated Hospital of Air Force Medical University,from January 2009 to September 2022,and according to the condition of pulmonary infection after admission,they were divided into infection group with 213 patients and non-infection group with 372 patients.The independent-samples t test or the Mann-Whitney U test was used for comparison of continuous data between two groups,and the chi-square test was used for comparison of categorical data between groups.The clinical data of these patients were collected.Univariate and multivariate Logistic regression analyses were used to investigate the risk factors for pulmonary infection in ACLF patients and establish a predictive model,and the receiver operating characteristic(ROC)curve was plotted to assess the predictive value of the model.The Hosmer-Lemeshow test was used to evaluate the degree of fitting of the model,and the ROC curve and the area under the ROC curve(AUC)were used to assess the predictive performance of the model.Results Among the 585 patients with ACLF,213 experienced pulmonary infection,with an infection rate of 36.41%.The multivariate logistic analysis showed that upper gastrointestinal bleeding(odds ratio[OR]=2.463,P=0.047),infection at other sites(OR=2.218,P=0.004),femoral vein catheterization(OR=2.520,P＜0.001),and combined use of two or more antibiotics(OR=2.969,P＜0.001)were risk factors for pulmonary infection in ACLF patients.These factors were included in the risk factor predictive model of Logit(P)=-1.869+0.901×upper gastrointestinal bleeding+0.755×infection at other sites+0.924×femoral vein catheterization+1.088×combined use of two or more antibiotics.The ROC curve analysis showed that the model had a good predictive value(Hosmer-Lemeshow χ2=3.839,P=0.698),with an AUC of 0.753(95%confidence interval:0.700-0.772).Conclusion There is a relatively high incidence rate of pulmonary infection in patients with ACLF,and upper gastrointestinal bleeding,spontaneous peritonitis,femoral vein catheterization,and combined use of two or more antibiotics are related risk factors.The model established based on these factors can effectively predict the onset of pulmonary infection in ACLF patients.

Objective:To explore the effect of exercise rehabilitation on pulmonary function, aerobic capacity and quality of life in children with bronchial asthma.Methods:According to the PICOS principle, China National Knowledge Infrastructure (CNKI) , VIP, Wanfang Database, SinoMed, Web of Science, Cochrane Library, PubMed, Embase and CINAHL were used to search for all Chinese and English randomized controlled trials on the effect of exercise rehabilitation on children with bronchial asthma from January 1, 2000 to December 23, 2021. The Cochrane manual was used to systematically review the literature. Meta-analysis was performed using RevMan 5.3.Results:Finally, 15 articles were included, with a total of 936 subjects. Meta-analysis results showed that exercise rehabilitation could improve percentage of forced vital capacity in the predicted value (FVC%) [mean difference ( MD) =2.75, 95% confidence interval ( CI) (1.22-4.28) , P=0.000 4] , percentage of forced expiratory volume in one second in predicted value (FEV 1%) [standardized mean difference ( SMD) =0.22, 95% CI (0.07-0.36) , P=0.003] , percentage of peak expiratory flow in the predicted value (PEF%) [ MD=7.15, 95% CI (3.30-11.00) , P=0.000 3] , maximum oxygen uptake (VO 2max) [ MD=5.86, 95% CI (2.53-9.19) , P=0.000 6] and quality of life [ MD=0.67, 95% CI (0.43-0.91) , P<0.000 01] , but there was no statistically significant difference in improving the ratio of FEV 1% to FVC% (FEV 1/FVC%) [ MD=-0.97, 95% CI (-3.55-1.61) , P=0.46] . Conclusions:Exercise rehabilitation can improve partial pulmonary function, aerobic capacity and quality of life in children with asthma. However, it still needs to continue to be promoted in the clinical practice, in order to verify its effectiveness with more high-quality research.