OBJECTIVE:To provide reference for the clinical rational drug use. METHODS:Cross-sectional survey was adopt-ed to statistically analyze the off-label use of inpatient(489 prescriptions)and outpatient prescriptions(466 prescriptions)in our hos-pital in Jun. 19,2014. RESULTS:The prescription items and ratios of off-label use in inpatients and outpatients in our hospital were 240,14.1%(240/1 704)and 149,17.4%(149/852),respectively. The top 4 types of drug off-label use included changing ad-ministration frequency,indications,compatibility concentrations of injections and dosage. CONCLUSIONS:Some of off-label use are rational,supporting by kinds of guidelines,expert consensus and literature reporting;while some are irrational,clinic should avoid this kind of irrational use and be strictly controlled by pharmacists. Meanwhile,it is suggested that the drug manufacturers up-date the instructions timely to provide reference for ensuring safety drug use of patients.

AIM: At present, there is not a unified understanding on the total quantity and distribution of skeletal muscles in a normal human body. In this paper, we arranged the number of human skeletal muscles by detailed anatomic observation and record of an adult male corpse to provide reference for future scientific research and teaching. METHODS: The experiment was conducted in the anatomical laboratory of Hebei Institute of Physical Education between October 2005 and March 2006. Two complete adult male corpses fixed by 40 g/L formaldehyde were given a detailed anatomic observation by removing the skin and subcutaneous tissue, and exposing the skeletal muscles of the whole body from superficial to deep layers. The initiation and end sites of muscles were isolated and the obvious muscle fibers were exposed to carefully observe and record the quantity of skeletal muscles. It was noticed that because the muscle fibers were less, when dissecting the mimetic muscle, the thin layer of skin and fewer subcutaneous tissues should be cut parallel to the skin with a blade as soon as the mimetic muscle scattered between subcutaneous tissue, but not isolate the muscle fiber from deep layer, which might remove the muscle fiber and subcutaneous, and lead no obvious muscle left. The sphincter muscle of some organs should be dissected from the superficial to the deep layer of the muscles. It was necessary to look up some data to supplement the muscles with less occurrence and unusual for corpse. RESULTS: There were 549 pieces muscles in the whole body of a normal person including 270 pairs muscles and 9 pieces of non-pair skeletal muscles such as orbicularis oris muscle, arytenoids muscle, diaphragma, interspinal muscles, sphincter muscle of anus and musculus sphincter urethrae. CONCLUSION: Although the muscles not found in the corpses are supplemented by looking up the data, it is necessary to further observe, study and discuss through different corpse specimens.

132 cases of persistent occipital-transverse position and 60 cases of persistent occipital-posterior position were treated in our department in 1987.In this article,the retrospective clinical studies were reported.The former made up 9.21% and the latter made up 4.18% of the total deliveries.The rate of operative delivery was 93.33%.The cause and early diagnosis were discussed.Then we express here our preliminary opinion upon the treatment.

Objective To understand the medical staff's real experience after implementing patients participate and interactive health education method.Methods A qualitative method was conducted with 2 doctors and 7 nurses.Data were analyzed based on Colaizzi phenomenotogical research method.Results 3 themes were extracted:conflict,including the role and the education methods;the benefits of patients participate and interactive health education method,such as palliative the relationship between medical workers and patients,and help patients to manage diseases,etc;and obstacles as work burden and time limit of medical staff,patients with low health literacy,negative psychology,lack of supervision and timely feedback on both sides.Conclusions Patients participate and interactive health education method is beneficial and feasible,but some obstacles we should faced in the implementation process.Its smooth implementation needs medical staff change idea,and also needs the support of some objective factors.

OBJECTIVE： To compare between two different modes of stability test for norgestrienone acetate.METHODS： HPLC(Resolve C18 column， 5μ m ID， 4.6mm× 250mm as fixed phase， a mixture of methanol and purified water (7∶ 3) as mobile phase， detecting wavelength 243nm， flow rate 1ml/min) and TLC.RESULTS： Two tests obtained the same result.CONCLUSION： The methods used are feasible for stability test.

Traditional Chinese medicine is considered to have a lot of advantages in many ways when compared with modern medi-cine;however, the advantages are usually difficult to be widely accepted due to lack of evidence. Under the background that the evi-dence-base is paid universal attention all over the world, there is no doubt that it will bring negative effects on the development of tradi-tional Chinese medicine. Providing scientific and rational evidence base is essential for the healthy development of traditional Chinese medicine, and pharmacoeconomic is expected to play an important role in the area. The paper reviewed the study and application status of traditional Chinese medicine and pointed out the main problems, and furthermore, the corresponding countermeasures and sugges-tions were put forward in order to promote the research and application of pharmacoeconomic in the field of traditional Chinese medi-cine.

Objective To investigate the correlation value between the impression depth of umbilical cord around neck and the blood flow indexes of middle cerebral artery (MCA) and umbilical artery (UA) in fetus.Methods Totally 139 late pregnancy fetuses of umbilical cord around neck and 28 normal fetuses were enrolled in the study.The systolic maximum velocity/diastolic minimum velocity (S/D),resistence index (RI),pulsatility index (PI) of MCA and UA in fetuses were measured by Doppler ultrasound,and the correlation of the pressure trace depth with MCA and UA blood flow parameters were analyzed.Results The pressure trace depth of umbilical cord around neck and the S/D,RI,PI of MCA were positively correlated (one round of umbilical cord around neck,r=0.32,0.32,0.35,two or more rounds of umbilical cord around neck,r=0.71,0.69,0.53,all P＜0.05).The pressure trace depth of umbilical cord around neck and the S/D,RI,PI of UA had no correlation.Compared with normal fetuses,the parameters of UA had no significant differences in fetuses with umbilical cord around neck (all P＞0.05).The S/D,RI,PI of MCA in fetuses with pressure trace depth ≥0.80 cm and fetuses with two or more rounds of umbilical cord around neck were higher than those of normal fetuses (all P＜0.05).Fetuses with two or more rounds of umbilical cord around neck had obviously increased cesarean rate compared with normal fetuses.Compared with normal fetuses,the fetuses with pressure trace depth ≥0.80 cm had increased abnormal fetal heart rate,prolonged labor time during the second stage (all P＜0.05).Conclusion In late pregnancy fetuses with umbilical cord around neck,the blood flow parameters of MCA are more sensitive than those of UA.The pressure trace depth ≥ 0.80 cm may lead to intrauterine fetal anoxia.

Objectives To summarize the experience of nursing care to children with dermatomyositis complicated with interstitial pneumonia.Methods The nursing histories of 11 cases of children dermatomyositis complicated with interstitial pneumonia were retrospectively looked into for summarizing the nursing measures.Results The diseases were both effectively controlled in all the children,who were given maintenance therapy by oral taking of hormone after discharge.Conclusion Such nursing measures as close observation of disease,enhanced nursing and first aid of respiratory failure,nursing of infection and secondary infection,care after mesenchymal stem cells transplantation,strengthened disinfection and isolation,are of significance for controlling the disease.

OBJECTIVE To investigate the effective methods for nosocomial infection(NI) management and to adapt the new needs of quality-control in modern hospital.METHODS Under the circumstance to start using the ward building and reconstructing the outpatient building,by applying reasonable flow of work,making practicable rules and regulations,depending on new management mode of total cost-quality-effect and supervision-control-administration,to improve our NI management level in all directions in practice.RESULTS The reorganization towards NI management of all the staff had been boost,the rules and regulations of NI management had been carried out and NI had been controlled effectively.CONCLUSIONS Essential facilities are the matericl basis of NI management.Modernized management methods and process management are very meaningful to elevate the NI management level,and to ensure the quality of medical service.

Objective To observe the effect of electroacupuncture(EA) on the profiles of hippocampal whole-genome expression in depression rats so as to study its underlying mechanism in relieving depression.Methods Thirty male SD rats were randomized into normal,model and EA groups(n=10/group).Depression model was established by chronic unpredictable stress stimulation(forced ice-water swimming,electric shock,tail-clamping,etc.) and lonely raising for 21 days.EA(2 Hz,1 mA) was applied to "Baihui"(GV 20) and "Yintang"(EX-HN 3) for 15 min,once daily for 7 days.The rats' ethological activities(horizontal and vertical movements) were detected with Open-field test in Morris labyrinth,and 1% sucrose solution consumption was detected.After termination of the treatment,the rats were killed and their hippocampal tissues were taken out for analyzing the whole-genome expression with Roche-NimbleGen chips(Rattus norvegicus 12?135 Karray).Results Compared with normal group,the distance of horizontal movement,rearing times,and sucrose consumption at day 21 and day 28 of model group decreased considerably(P