1.Progress in stem cell research
Chinese Pharmacological Bulletin 1986;0(05):-
Stem cells exist not only in the developing mammalian embryo but also in certain areas of various adult tissues. In embryo, they can take part in the development of tissues and the whole organism while in adult, they are thought to be involved in cell metabolism. With the development of research in embryo and nervous system, the field of stem cells has become a hot point in scientific world. A brief summary is made on stem cell biology and its potential medical importance.
2.Effect of single lung ventilation for pneumoresection on blood gas
Yong ZHANG ; Lihong ZHANG ; Jie SHEN ;
China Oncology 2001;0(03):-
Purpose:To study the effect of single lung ventilation for pneumoresection on blood gas. Methods:20 patients with lung cancer whose lung function were normal or reduced slightly before the operation were divided into 2 groups (A and B),of 10 cases each.The patients in group A underwent single lung ventilation with an endobronchial tube during the operation ,and two lung ventilation with an endotracheal in group B.Blood gas analysis was measured in every patient before, during and after the operation.Results:The values of blood gas analysis during the operation in all patients were normal and no significant difference was found between the two groups during the same time. Conclusions:The patients with lung cancer whose lung function were normal or reduced slightly before the operation can receive single lung ventilation safely for pneumoresection.[
3.The effect of event-related potentials N400 in rehabilitation for patients with post-stroke aphasia
Lihong SHEN ; Bing ZHANG ; Junpeng ZHAO
Chinese Journal of Primary Medicine and Pharmacy 2013;20(8):1125-1126
Objective To explore the siqnificance of event related potential(ERP) N400 on stroke patients with aphasia and provide theoretical basis for clinical operations.Methods 29 stroke patients with aphasia(aphasia group) and 58 stroke patients without aphasia(control group) were selected,which were examined with N400.The latency and amplitude of N400 were compared between the two groups.Results The difference waves' latency and amplitude of aphasia group were longer and higher than those of control group.The difference had statistical significance (all P < 0.05).Conclusion N400 is a significant marker for the language disturbance of aphasia patients.
4.Management of Medical Refuse Is Important to Control Hospital Infection
Guyu SHEN ; Lihong ZHU ; Huifang HUANG
Chinese Journal of Nosocomiology 1994;0(01):-
OBJECTIVE To strengthen the management of medical refuse in order to control the onset of hospital(infection.) METHODS It has been done including setting up special tissue,formulating supervising system,strengthening training,carrying out supervising measures and strengthening examination and inspection.(RESULTS) It could prevent hospital infection effectively to regulate the whole course of the medical refuses(collection,) storage,dealing with and registration.CONCLUSIONS It is very important to strengthen the management of medical refuse in order to prevent hospital infection.
5.Radiotherapy of primary cardiac neoplasm
Wenjiang SHEN ; Lihong ZHU ; Ping LI
Chinese Journal of Radiation Oncology 1992;0(04):-
Objective To evaluate the result of radiotherapy for primary cardiac neoplasm.Methods A patients with primary malignant mucinous Schwannoma in th left ventriclular wall had been treated by conservative surgery. He,then,received fast neutron radiotherapy one year after wards. Radiotherapy was given through opposing anterior and posterior fields of 7.8 cm?7.8 cm. The total radiation dose was 1?004.95 ncGy with 11 fractions of 100 ncGy in 48 days.Results The function of the patient's heart recovered after treatment. The patients has been followed for 5 years without evidence of recurrence or distance metastased. Conclusion Fast neutron radiotherapy is effective in the treatment of primary cardiac neoplasms by surgery combined with postoperative radiotherapy. It could improve the prognosis of patients with primary cardiac neoplasms.
6.Effects of X-ray irradiation on focal adhesion kinase in vascular smooth muscle cells
Ping LI ; Wenjiang SHEN ; Lihong ZHU
Chinese Journal of Radiation Oncology 1993;0(03):-
Objective To investigate the signaling transduction mechanisms of inhibiting effect of radiation on vascular smooth muscle cells(VSMC).Methods Cell culture in vitro and semi quantitative reverse transcription polymerase chain reaction(RT PCR) were used to observe the dynamic change of VSMC focal adhesion kinase(FAK) on the mRNA expression level and result of the control group as compared to those of the irradiation ones at 2.5,10,15,20 Gy.Results Dose of 2~20?Gy irradiation down regulated the expression of FAK mRNA. At hour 48 after 2~20?Gy irradiation,the FAK mRNA expressions were all less than the control ones(F=364.21,P
7.Comparison between shikani optical stylet and Mc coy laryngoscope on elder patients with intratracheal intubation anesthesia
Lihong SHEN ; Binjiang ZHAO ; Lei GUAN ; Feng FENG
China Journal of Endoscopy 2017;23(3):20-24
Objective To compare shikani optical stylet and Mc coy laryngoscope on elder patients with intratracheal intubation anesthesia.Methods 112 cases of elder patients with intratracheal intubation anesthesia were enrolled as study objects, all patients were divided into shikani optical stylet group (52 cases), Mc coy laryngoscope group (60 cases) according to different intubation way. Then detect the hemodynamic parameters, stress-related indicators, EEG relevant indicators of the two groups.Results One time success rate and total success rate in Shikani visual laryngoscope group was higher than Mc Coy visual laryngoscope group, while many times intubation rate was lower (P < 0.05); T1, T2 MAP, HR levels were lower in Shikani optical stylet group than Mc Coy laryngoscope group patients (P < 0.05); Plasma levels of epinephrine, norepinephrine, and glucose on T1, T2 in Shikani optical stylet group was lower than that in Mc Coy laryngoscope group (P < 0.05); T1, T2 BIS, ECoG grading, αβ% values in Shikani optical stylet group was lower than that in Mc coy laryngoscope group (P < 0.05).Conclusions Elderly patients with intratracheal intubation anesthesia received shikani optical stylet can enhance the success rate of intubation and effectively stabilize patients circulatory system, reduce excessive physical stress caused by various system dysfunction, which shows positive significance.
8.Value of neutrophil-lymphocyte count ratio in diagnosing bloodstream infection
Lihong SHEN ; Yongde CHEN ; Haopeng CHAO ; Wenqi SONG ; Xiaoyi TIAN
Basic & Clinical Medicine 2017;37(7):1000-1003
Objective To explore the diagnostic value of five infection markers in bloodstream infection.Methods Randomly selected 110 bloodstream infection patients with positive blood cultures and 30 bacterial infection patients with negative blood cultures.Blood was simultaneously drawn with blood cultures;the complete blood count and C-reactive protein (CRP) levels were measured.The white blood cell count (WBC),neutrophil count (NEU),lymphocyte count (LMY),CRP level and neutrophil-lymphocyte count ratio (NLCR) were compared between the two groups.Results The levels of WBC,NEU,NLCR and CRP in bloodstream infection group were significantly higher than those in control group (P<0.05),while LYM was significantly lower than that in control group (P< 0.05).Among these five infection markers,the area under the receiver operating characteristic curve (ROC-AUC) was the highest for NLCR (0.808) and LMY (0.756);when the cutoff value for NLCR was >9.33,sensitivity was 63.6%,specificity was 93.3%;and the cutoff value for LYM was ≤0.97,sensitivity was 58.2%,specificity was 86.7%.Furthermore,the NLCR of patients with gram-negative bloodstream infection was higher than those in patients with gram-positive bloodstream infection.NLCR showed important clinical significance in distinguishing strains of different bloodstream infections.Conclusions NLCR is the better predictors than routine parameters in diagnosing bloodstream infection.
9.Expressions and clinical value of serum SGF, TSGF and CEA in NSCLC patients
Chengde LI ; Nanyang LI ; Xueji SHEN ; Haizhu LI ; Lihong LIANG
Chinese Journal of Primary Medicine and Pharmacy 2009;16(10):1745-1746
Objective To establish a serological diagnostic method about NSCLC by investigating the expres-sion of 3 tumor markers of the sulfate glycosaminoglyean fragments(SGF), TSGF and CEA in NSCLC patients' serum. Methods To assay the level of SGF,TSGF and CEA in 50 NSCLC patients with latex particleagglutiation test,colori-metry of biochemistry and CLIA, respectively. Compared the clinical value of different examination combination way in NSCLC diagnosis value. Results There was high difference value between the Ⅰ - Ⅱ stage and the Ⅲ time,the Ⅲ time and the Ⅳ time about the level of SGF(P <0.05) in NSCLC patients. The specificity between SGF,TSGF and CEA each single item and the SGF and TSGF combination examination were not significant(P > 0.05). The semitivity between the SGF and TSGF combination and the SGF,TSGF and CEA combination was not significant(P >0.05), its specificity had significant difference(P <0.05). Conclusions There are higher expression about the 3 tumor mark-ers in NSCLC patients' serum. In the different combination examination, SGF and TSGF combined has great clinical value than other combinations to diagnosis NSCLC.
10.Effect of different withdrawal time of dexmedetomidine on the quality of general anesthesia recovery
Xiaoyun HU ; Binjiang ZHAO ; Xiuyun WANG ; Lihong SHEN ; Feng FENG
Journal of Chinese Physician 2014;16(12):1606-1609
Objective To explore effect of different withdrawal time of dexmedetomidine (DEX) on the quality of general anesthesia recovery.Methods Eighty patients of ASA Ⅰ or Ⅱ undergoing lymph surgery were randomly assigned to four groups (n =20).Groups D1,D2 and D3 received DEX 0.5 μg/kg as bolus before induction,continued with 0.5 μg/(kg · h) by infusion until one hour,30 min before the end of operation and the end of operation,respectively.Group C received equal volume of normal saline.Mean artery pressure (MAP),heart rate (HR) and pulse oxygen saturation (SpO2) were observed during and after operation.Spontaneous respiration recovery time,eyes open time,extubation time,orientation recovery time,observer's assessment of alertness/sedation score (OAA/S),restlessness score (RS),and visual analogue scales (VAS) were observed after operation.Results For MAP and HR in Groups D2 and D3,there were no statistically significant difference during extubation compared to those at preoperation,but at the same time point,they were lower than those in group C (P < 0.05).For groups C and D1,MAP and HR at extubation and 5 min after extubation were higher than those at preoperation (P <0.05).Spontaneous respiration recovery time,eyes open time,extubation time,orientation recovery time in group D3 were significantly longer than those in Group C (P < 0.05),while there were no statistically significantly difference between groups D1,D2,and group C.OAA/S in group D3 was significantly lower than that in group C (P < 0.05) at extubation.Incidence of restlessness,VAS,and cases given analgesic 2 hours after operation in groups D2 and D3 were significantly lower than those in groups C and D1.Compared to those in group C,dosages of propofol and remifentanil in groups D2 and D3 were significantly lower.Conclusions Dexmedetomidine administered of 0.5 μg/kg before induction,continued with infusion of 0.5 μg/(kg · h) until 30 min before the end of operation,may improve emergence,without influencing the awakening time of patients,and prolong the duration time of analgesia which comfort the patients.