Objective To develop and explore the clinical application effect of orthopedic protective trestle for post-operative patients with lower limb fracture.Methods Totally 60 patients with lower limb fracture that hospitalized in Osteopathic Department from March to June 2015 were randomly divided into the observation group(n=30) and the control group(n=30). Patients in the control group were given Thomas trestle for the fixation while patients in the observation group were given orthopedic protective trestle for the fixation. The pain score, average hospitalization days and patients′satisfaction degree in two groups were compared. Results The pain score of patients in the observation group after 48 h was (3.50±0.63) points, which was significantly lower than the score in the control group (5.53±0.82) points (t=10.78,P<0.05);the average hospitalization days in the observation group was (16.47±2.68) d, which was significantly lower than that in the control group (22.47± 7.32) d (t=4.22,P<0.05);the satisfaction score of patients in the observation group was (8.80±0.61) points, which was significantly higher than the score in the control group (6.93±1.36) points (t=-6.85,P<0.05). Conclusions Orthopedic protective trestle for patients with lower limb fracture can relieve the pain of patients, reduce the length of average hospitalization days and improve the satisfaction of patients.