Objective To investigate the characteristics of risk factors and coronary angiography (CAG)in young patients with acute myocardial infarction(AMI).Methods A total of 36 consecutive AMI female patients (age≤44 years)who underwent coronary angiography were retrospectively retrieved from the database,and 90 AMI patients whose age >44 years who also underwent coronary angiography were enrolled as a control (elderly)group.Characteristics of risk factors and coronary angiography were com-pared between the two groups.Results The risk factors:BMI,family history of coronary heart disease and high triglycerides(TG)were major in the youth group.The percentage of single-branch lesion was lower in the young patients.The prevalence of left anterior descending (LAD)was higher in the young patients(P <0.05).Conclusions The main risk factors in young and elderly patients are significantly different.The out-comes of CAG in the young patients show the coronary lesion are mostly single vessel lesion,and early inter-vention may improve prognosis.

Background:Irritable bowel syndrome (IBS)is a commonly seen functional intestinal disorder. The association between Helicobacter pylori (Hp)infection and IBS is not clarified yet. Aims:To investigate the role of Hp eradication in diarrhea-predominant IBS (IBS-D)and the relationship between Hp infection and IBS-D. Methods:A total of 335 IBS-D patients and 335 health examination subjects were recruited from Jan. 2009 to Dec. 2015 at Transportation Center Hospital of Yunnan Province and People's Hospital of Xishuangbanna Dai Autonomous Prefecture. All IBS-D patients were hospitalized patients and fulfilled the Rome Ⅲ criteria. Positive for both rapid urease test and 14 C-urea breath test was defined as Hp infection. Hp-positive IBS-D patients recruited in 2005 received Hp eradication therapy and were allocated into two groups according to the results of eradication therapy. Pinaverium bromide and montmorillonite powder were given in both groups and the clinical efficacy for IBS symptoms was assessed after treatment and followed up for 6 months. Results:The Hp infection rate of IBS-D patients was significantly higher than that in healthy controls (53. 7% vs. 41. 8%,P < 0. 05). In IBS-D patients received Hp eradication therapy,51 were allocated into eradicated group and 26 into non-eradicated group. No significant differences were observed in individual symptoms including abdominal pain/discomfort,bloating and stool frequency and the overall efficacy for global symptoms (68. 6% vs. 65. 4%)between the two groups (P > 0. 05). After a 6-month follow up,the differences were still insignificant (P > 0. 05). Conclusions:Hp infection is more prevalent in IBS-D patients than in general population,however,eradication of Hp has no impact on IBS symptoms. The association between Hp infection and IBS-D needs further study.

Objective To establish a thin layer Chromatograph-Fluores cent method for the determination of karanjin in Radix of Fofdia caulifora. Methods Anhydrous-EtOH is solution, thin-sheet is silica gel, expanding solution is Benzene-EtoAc (8.5∶1.5), with excitation wavelength at 355 nm and emission wavelength at 428 nm. Results The average recovery of karanjin was 99.14% and RSD was 1.94% (n =5). There is a good linear relationship within the range of 0.138～0.69 ?g of karanjin. Conclusion The method is convenient, sensitive, accurate and reproducible, and can be used the quality control of the Radix of Fofdia caulifora.

Objective To investigate the effect of carvedilol combined with spironolactone in the treatment of elderly patients with chronic heart failure clinical efficacy and to provide reference for clinical treatment of formulation. Methods 104 elderly patients with chronic heart failure were randomly divided into observation group and control group,52 cases were randomly divided into observation group and control group.Control group intervention in accord-ance with the conventional treatment of chronic heart failure program,the observation group in the conventional scheme based on,combined with oral carvedilol and spironolactone therapy.6 months after treatment,clinical efficacy was compared between the two groups.The results of echocardiography before and after treatment in two groups were compared.The adverse reactions in the treatment process were compared.Results The effective rate in the observation group was 59.62%,the total effective rate was 96.15%,which were significantly higher than those of the control group (χ2 =4.10,9.82,all P <0.05);After treatment,LVEDD and LVESD of the two groups were significantly lower than those before treatment[(51.89 ±7.06)mm,(41.39 ±6.85)mm,(60.71 ±7.43)mm,(51.02 ±7.95)mm], LVEF[(52.31 ±9.02)% and (41.64 ±7.73)]were significantly higher than that before treatment,there were statistifically significant differences between the two groups(t =4.92,5.10,5.45,2.87,2.98,3.03,all P <0.05);After treatment,LVEDD[(51.89 ±7.06 )mm],LVESD [(41.39 ±6.85 )mm]of the observation group were significantly lower than those of the control group,and LVEF(52.31 ±9.02)% were significantly higher than that of the control group,there were statistifically significant differences between the two groups (t =3.02,2.98,2.97,all P <0.05);There was no significant difference in the incidence of adverse reactions between the two groups(P >0.05).Conclusion Carvedilol combined with spironolactone can significantly improve the clinical effect of the treatment of elderly patients with chronic heart failure,effectively improve the left ventricular remodeling in patients with,improve myocardial contractility in patients and has good security.

Objective To determine the characteristic features of clinical manifestation, imaging and pathology in the patients with hypertrophic cranial pachymeningitis (HCP). Methods All clinical data of 1 patient with HCP were studied retrospectively. Results The patient presented with heavy headache, progressive visual acuity decreased and hoarse voice. Brain MRI displayed abnormal strengthening signals in cerebral dura mater, especially in cerebral falx and tentorium of cerebellum. Pathological examination demonstrated chronic inflammation changes including numerous plasmocytes infiltration, accrementition and glassy degeneration of fibrous tissue, formation of granulation tissue. Therapy with corticosteroid hormone showed good effect for this patient.Conclusions HCP mainly presents with headache and paralysis of multiple cranial nerves. Distinctive sign on brain MRI is strengthening signal in cerebral dura. Chronic inflammation is the pathological change of this disease and pathological examination plays important role in diagnosis of HCP.

Objective: To investigate the relationship between serum uric acid(SUA) and prevalence of hyperuricemia(HUM) and the effects of dietary factors on HUM . Methods: Total 748 subjects from Guangzhou were questioned and SUA and body mass index (BMI) was measured by trained investigators. Results: The mean SUA concentration was (384.6?74.8)mmol/L in males vs (286.3?65.3) mmol/L in females, (P

As social views on disability changed,how to support intellectual disabled adult so they can be involved in ordinary social life is not only the hot topic of special education and rehabilitation service system,but also the concern of psychologists.For the improvement of social inclusion,psychologists should provide assessment,intervention and support for intellectual disabled adults at personal and social supportive levels,and relative policy advices for the government should be included.

To develop a new temperature control moxibustion device so as to improve the clinical therapeutic effect of moxibustion. According to the thermal effect of moxibustion, with the designs such as the modern electronic equipment (temperature control system) adopted and in combination of smoke filtration device and oxygen mask device, a new temperature control moxibustion device was developed. The new temperature control moxibustion device may achieve the automatic regulation of temperature and distance and avoid the pollution and irritation of smoke and flavor, etc. As a result, the traditional moxibustion therapy can better play its efficacy and display its safety and convenience in practice.
Equipment Design ; Humans ; Moxibustion ; instrumentation ; methods ; Temperature

BACKGROUND:As a kind of stressor, exercise-induced fatigue surely can lead to the material and functional changes of certain nerve nucleus within brain.It is still uncertain on what kind of nucleus closely relate to exer-cise-induced fatigue and what materials induce the functional or/and structural changes of tired central nerve.OBJECTIVE:To study the relationship between nitric oxide synthase (NOS) in ventromedial hypothalamic nucleus(VMH),dorsomedial hypothalamic nucleus(DMH) and exercise-induced fatigue.DESIGN:Randomized controlled study.MATERIALS:The experiment was completed in the Department of Human Anatomy of North University of China and Shanxi Medical University during October 2003 to January 2004.Twenty male Wister rats of clean class were selected.INTERVENTIONS:The rats were randomly divided into experimental group and control group with each of 10 rats.The rats in experimental group were made exercise-induced fatigue animal model by doing heavy load swimming until they were exhausted for 4 consecutive weeks. After the model was built,ABC immunohistochemical method was used to observe the expression of neuronal NOS (nNOS) in neurons of VMH ,and DMH and image analysis and statistic process were conducted.MAIN OUTCOME MEASURES:Number of nNOS positive cells in per unit visual field; Area and gray of positive substance.RESULTS:The number of nNOS positive cells in VMH of fatigue group was (25.25±7.35)/visual field which was much greater than that of control group (9.70±3.20)/visual field(P＜ 0.001).The area of nNOS positive substance was (3 867.75±1 940.41)μm2/visual field which was greater than that of control group(750.13±579.88)μm2/visual field(P ＜ 0.001). The number of nNOS positive cells in DMH of fatigue group was (30.25±7.87) /visual field which was much greater than that of control group (14.00±4.99) /visual field. And the area of nNOS positive substance was (4 512.06±1 243.93) μm2/visual field that was much greater than that of control group(782.46±711.46)μm2/visual field(P ＜ 0.001).CONCLUSION:The nNOS positive neurons in VMH and DMH neurons are closely related to the occurrence of central exercise-induced fatigue.Nitric oxide may play an important role in regulation of VMH and DMH to stress caused by fatigue.

Objective To study the characteristics of the serum free light chain ( sFLC ) and cytokines levels and the effects of cyclophosphamide (CTX) on patients with primary Sj(0)gren's syndrome (pSS) complicated with amyloidosis.Methods Nine patients of pSS with amyloidosis who were admitted to Department of Rheumatology of the hospital from Jan 2005 to Mar 2011 were selected.The serum levels of sFLC and cytokines TNF-α,TGF-β1,IL-4 were measured before and 3,6,12 months after the treatment respectively.Meanwhile,Twelve patients with pSS without complications were selected as controls.Repeated measures analysis of variance was used for data analysis.Results The sFLC in serum of pSS patients with amyloidosis was λ type,the κ type was not found.The level of serum sFLC after 12 months treatment [(22±42) mg/L]was significantly lower than before treatment [(180±15) mg/L].The levels of TNF-α,TGF-β1,IL-4 after 12months treatment [(24.0±1A),(58±5),(38.8±3.2) ng/L,respectively] were significantly lower than before treatment [(31.1±L0),(65±5),(61.2±3.8) ng/L,respectively].Conclusion The levels of serum sFLC and eytokines are abnormally increased in patients of pSS with amyloidosis.After treatment,the levels of cytokines are decreased initially which indicates that these cytokines may play a key role in the pathogenesis of pSS.CTX therapy may lead to better efficacy and more favorable prognosis.