Objective To investigate the status quo of social-psychological adjustment and self-efficacy in patients after ostomy and to analyze the correlation between them as well as the influencing factors of social-psychological adjustment. Methods Totally 148 patients who received ostomy from 5 Class Ⅲ Grade A hospitals in Nanjing between March and July 2016 were selected by convenient sampling. The Chinese version of Ostomates' Adjustment Inventory, Self-Efficacy Questionnaire for Stoma and the Self-Designed General Information Questionnaire were used to investigate the patients. The Pearson correlation analysis was used to analyze the relationship between the level of social-psychological adjustment and self-efficacy, single factor analysis and the multivariate stepwise regression analysis were used to analyze the factors influencing the level of social-psychological adjustment. Results The level of social-psychological adjustment in patients with stoma was (44.86±9.69), with only 6.8% of the patients being highly adaptive. The self-efficacy was (66.36±17.29)and only 1.4% of the patients showed high efficacy. There was a positive correlation between them (r=0.797, P<0.01). The multivariate stepwise linear regression analysis showed that self-efficacy, stoma complications, sex and stoma types were the influencing factors of social-psychological adjustment (β'=0.740,-0.177,0.100,-0.128;P< 0.05). Conclusions The patients after ostomy need to improve their social-psychological adjustment. Women and patients with stoma complications should gain more attention. Their self-efficacy may be improved with targeted intervention and follow-up instruction which can help them get adapted to stoma and return to theiry home and community as soon as possible.

Objective To develop the assessment scale of proactive health behavior ability for the disabled elderly in nursing homes and to test its reliability and validity.Methods The first draft of the scale was formed by literature review,qualitative interviews and Delphi method.From December 2023 to March 2024,525 disabled elderly people from 9 nursing homes in Sichuan Province and Chongqing City were selected as the survey subjects,and item analysis and reliability and validity test were carried out on the scale.30 disabled elderly people were re-investigated after 2 weeks to calculate the retest reliability of the scale.Results The scale consisted of 4 dimensions and 27 items.Exploratory factor analysis extracted 4 common factors,with the cumulative vanance contribution rate of 65.992％,and confirmatory factor analysis showed that the modified model fitting index was within acceptable range.The content validity index at item level was 0.917-1.000,and that at scale level was 0.997.The Cronbach's α coefficient,test-retest reliability and split-half reliability of the total scale were 0.944,0.997 and 0.882,respectively.Conclusion The scale has good reliability and validity,and it can be used to evaluate the proactive health behavior ability of the disabled elderly in nursing homes.

Vincristine, a widely used chemotherapeutic agent for treating different cancer, often induces severe peripheral neuropathic pain. A common symptom of vincristine-induced peripheral neuropathic pain is mechanical allodynia and hyperalgesia. However, mechanisms underlying vincristine-induced mechanical allodynia and hyperalgesia are not well understood. In the present study, we show with behavioral assessment in rats that vincristine induces mechanical allodynia and hyperalgesia in a PIEZO2 channel-dependent manner since gene knockdown or pharmacological inhibition of PIEZO2 channels alleviates vincristine-induced mechanical hypersensitivity. Electrophysiological results show that vincristine potentiates PIEZO2 rapidly adapting (RA) mechanically-activated (MA) currents in rat dorsal root ganglion (DRG) neurons. We have found that vincristine-induced potentiation of PIEZO2 MA currents is due to the enhancement of static plasma membrane tension (SPMT) of these cells following vincristine treatment. Reducing SPMT of DRG neurons by cytochalasin D (CD), a disruptor of the actin filament, abolishes vincristine-induced potentiation of PIEZO2 MA currents, and suppresses vincristine-induced mechanical hypersensitivity in rats. Collectively, enhancing SPMT and subsequently potentiating PIEZO2 MA currents in primary afferent neurons may be an underlying mechanism responsible for vincristine-induced mechanical allodynia and hyperalgesia in rats. Targeting to inhibit PIEZO2 channels may be an effective analgesic method to attenuate vincristine-induced mechanical hypersensitivity.