Objective To compare the different ways of alkaline mouthwash slobber use in preventing the oral infection in patients with fever. Methods The patients who satisfied the requirements were involved and randomly divided into A, B and C group. A group did not use alkaline mouthwash; B group prescribed alkaline mouthwash slobber following the doctor's advice; C group received propaganda and demonstration of intensive use of the alkaline mouthwash, and then used the slobber in right way under the surveillance of nurses. The infection rates of oral ulcer and oral leukoplakia were compared and analyzed among the three groups. Results The incidence rates of oral ulcer and oral leukoplakia gradually decreased among the three groups and the differences had statistical significance (χ2=9.243,P=0.010;χ2=6.495,P=0.033).Compared with A group, there was no significant differences in the rates of oral ulcers and oral leukoplakia between Group A and B(OR=0.486, 95%CI:0.113-2.087;OR=0.557, 95%CI: 0.120-2.583), but the incidence rates of oral ulcers and oral leukoplakia gradually decreased(OR=0.024, 95%CI:0.002-0.293;OR=0.036, 95%CI:0.003-0.448)in C group. Conclusions Strengthening use of alkaline mouthwash slobber is more effective in preventing oral infection in patients with fever compared with the routine way of mouthwash use.

AIM: To establish identification and determination methods for aristolochic acids. METHODS: The extracts of the sample were developed on silica gel G F254 plate, using supernatant layer of the mixture of toluene-ethyl acetate-water-formic acid (20 ∶10 ∶1 ∶1) as the mobile phase. Chromatogram system:gradient elution with mobile phase consisting of (A) 1% acetic acid in water and (B) methanol was used. The initial condition was at 40% of B and gradient up to 100% B in 15 minutes before returning to the initial conditions. Detection was at 310 nm. The column temperature was set at 40℃ and flow-rate was set at 1.0 mL/min. RESULTS: TLC:the Rf value of aristolochic acid Ⅰ was 0.50 and aristolochic acid Ⅱ was 0.53. The results of assay were shown as follow: The average recovery of aristolochic acid Ⅰ was 103.3% (RSD=0.98%). The average recovery of aristolochic acid Ⅱ was 95.97% (RSD=1.2%). CONCLUSION: It reveals that the methods we described are accurate, rapid and reproducible.

Objective To explore the clinical features and gene mutations of blepharophimosis-ptosis-intellectual-disability syndrome (BPID). Methods The clinical data, diagnosis and treatment of a child with BPID in neonatal intensive care unit (NICU) were reviewed. Based on the literature retrieved from PubMed database, the common classification, clinical features, diagnosis and genetic counseling of BPID and its affiliated blepharophimosis-mental retardation syndromes (BMR) were reviewed. Results This male infant was 39 weeks of gestational age with birth weight of 1920 g, and was admitted to NICU 15 min after birth due to dyspnea. The main clinical manifestations were facial deformity such as biepharophimosis, ptosis and micromandible, inspiratory dyspnea with laryngeal cartilage softening, malformations of the thorax and feeding difficulties. A heterozygous mutation in UBE3B gene was identified by complete exon sequencing and he was diagnosed of BPID, a rare genetic disorder. Reviewing the literature, there was no relevant report in domestic. While one foreign literature was found to report 5 patients from 4 families having a subtype of BMR, a kind of autosomal recessive diseases caused by mutations in the UBE3B gene. Conclusion BPID is a rare clinical entity of BMR. Complete exon sequencing can be used to diagnose the disease.

Standardization of medical equipment acceptance regional specification is elaborated., by virtue of regional resources to further improve the acceptance level, to strengthen the quality management of medical devices is strengthened through the improvement of acceptance level with regional shared resources.
Equipment Safety ; standards ; Equipment and Supplies, Hospital ; standards ; Quality Control

Objective:To investigate the rate and timing of antenatal corticosteroid administration in the singleton preterm infants in our hospital, and explore the relationship between the timing of antenatal corticosteroid administration associated with the causes of preterm delivery and with neonatal outcomes.Methods:The study was a retrospective chart review of clinical data regarding singleton preterm neonates and their mothers from January 2016 and June 2020 at Peking University International Hospital.Optimal administration timing was defined as the first dose of antenatal dexamethasone given ≥48 h and ≤7 d before delivery.Suboptimal administration timing included any antenatal dexamethasone timing(<48 h or >7 d) that did not meet the optimal criteria.Antenatal dexamethasone administration timings were compared among preterm delivery with different causes.The neonatal outcomes of the optimal and suboptimal administration timing groups were compared.Results:The percentage of antenatal dexamethasone use was 89.16%, with 51.35% receiving optimal dexamethasone.Women with premature rupture of membranes were most likely to receive optimal dexamethasone(63.79%), followed by women with complications of pregnancy and other disorders(54.29%). The optimal dexamethasone rate of the women with cervical incompetence and preterm labor was relatively low(20% and 28%, respectively). The incidence of respiratory distress syndrome(RDS) of optimal administration timing group was lower than that in suboptimal administration timing group among neonates at <34 weeks of gestation( P<0.05). But there was no significant difference in the incidence of severe RDS, bronchopulmonary dysplasia, and need for pulmonary surfactant between two groups( P>0.05). The preterm infants with a gestational age between 34 and 34 + 6 weeks had no severe RDS or bronchopulmonary dysplasia.Compared with suboptimal administration timing group, the incidence of RDS and need for pulmonary surfactant of optimal administration timing group did not decrease significantly( P>0.05). Conclusion:The causes of preterm delivery affect the timing of antenatal dexamethasone administration.Optimizing the timing of antenatal dexamethasone administration can reduce the incidence of RDS among neonates less than 34 weeks of gestation.

Objective To discuss the impact of Neuman theory on anxiety and depression of hospitalized chronic obstructive pulmonary disease( COPD) patients.Methods Totals of 120 COPD patients in anxiety and depression condition were admitted to our department for treatment from January 2012 to January 2014.In accordance with the principles of randomized controlling, patients were equally divided into observation group and control group.The control group received routine care, while the observation group got care based on Neuman theory.Their anxiety and depression level before and after treatments were measured using Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD).Results Before treatment, there was no significant difference in the level of anxiety and depression between the two groups ( t =0.934 0, 0.450 6, respectively;P>0.05);however, after treatment, the anxiety level of the observation group was (12.6 ±6.4), which was significantly lower than (17.2 ±7.9) of the control group (t=3.504 6,P<0.05).The depression level of the observation group was (11.9 ±6.7), which was significantly lower than (16.1 ±6.3) of the control group (t=3.537 5,P<0.05).Conclusions The application of Neuman theory can relive the anxiety and depression of COPD patients and it is worthy of promotion.

Objective To analyze the current situation and trends of nursing home research to provide reference for further study.Methods The GoPubMed retrieval tool was used to retrieve the research literatures on the nursing home in PubMed database with the subject term "Nursing Homes",then the Excel2010 was used to statistically analyze the items such as the published literature's time distribution,geographical distribution,journals distribution,high-authors,related subjects.Results In total,46 436 articles were retrieved out.The publication amount was increased year by year.The largest publication amount was the United States,but China ranked at 21.Meanwhile the top 10 cities,top 10 journals and top 10 authors in publication amount were mainly in European and American countries,while China did not enter the ranks.The main research fields were community care,long-term care,etc.Conclusion In recent years,the research literatures about nursing homes present upward trend as a whole,but which are mainly concentrated in European and American countries.China is relatively weaker,so there is still much rising space.

OBJECTIVETo study the changes in quantitative kinetic parameters in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) during radiotherapy and their value for efficacy evaluation in patients with nasopharyngeal carcinoma (NPC).

METHODSTwenty-four patients with NPC that had been pathologically confirmed as poorly differentiated squamous cell carcinoma underwent conventional MRI and DCE-MRI scans 1-2 days before radiotherapy (Pre-RT), during radiotherapy (RT 50 Gy), and upon completion of radiotherapy (RT 70 Gy). Based on the two-compartment model and using the arterial input function deconvolution technique, we calculated the quantitative kinetic parameters of DCE-MRI (K(trans), kep, and Ve) of the tumor tissues, examined the correlation between the tumor regression rate (RS0-50) and the parameters on Pre-RT and RT 50 Gy, and compared the parameters for RT 70 Gy among the groups with different prognosis.

RESULTSThe K(trans) value of the tumor tissue decreased after radiotherapy and showed a significant difference between Pre-RT and RT 70 Gy, but not between Pre-RT and RT 50 Gy. The kep value decreased and Ve value increased after radiotherapy. The tumor regression rate was found to be positively correlated with the K(trans) value for Pre-RT (P=0.005) but negatively with the K(trans) value for RT 50 Gy (P=0.001). During the follow-up for 3 years, 5 patients died and 3 patients had distant metastases. No statistical differences in K(trans), kep, or Ve were found between the groups with different prognosis.

CONCLUSIONSThe kinetic parameters in DCE-MRI, which vary significantly during radiotherapy, allow monitoring of tumor angiogenesis and vascular permeability and quantitative assessment of treatment efficacy for NPC. K(trans) value for Pre-RT and RT 50 Gy can serve as an indicator for early efficacy assessment of radiotherapy and for treatment adjustment, but its relation with the long-term outcomes awaits further study.

Algorithms ; Capillary Permeability ; Carcinoma ; Carcinoma, Squamous Cell ; diagnosis ; Humans ; Magnetic Resonance Imaging ; Nasopharyngeal Neoplasms ; blood supply ; radiotherapy ; Neovascularization, Pathologic ; Prognosis ; Treatment Outcome

Objective:To study the impacts of different causes of preterm birth on the clinical outcomes of late preterm infants.Methods:From 2016 to 2022, clinical data of late preterm infants and their mothers delivered in our hospital were retrospectively analyzed. The infants were assigned into spontaneous preterm group, premature rupture of membranes (PROM) group and iatrogenic preterm group according to the causes of preterm birth. Perinatal data and neonatal outcomes were compared among these groups. Composite neonatal adverse outcomes (CNAO) included more than one of the following conditions: respiratory diseases, the need for respiratory support, hypoglycemia and neonatal asphyxia. Logistic regression analysis was used to analyze the correlation between causes of preterm birth and CNAO.Results:A total of 553 late preterm infants were enrolled in the study, including 111 cases (20.1%) in spontaneous preterm group, 305 cases (55.2%) in PROM group and 137 cases (24.8%) in iatrogenic preterm group. Iatrogenic preterm group had higher incidences of maternal hypertension during pregnancy, antenatal corticosteroid use, C-section delivery, neonatal respiratory diseases, respiratory support and CNAO than the other two groups ( P<0.05). Additionally, iatrogenic preterm group showed lower birth weight (BW) than the other two groups ( P<0.05). No significant differences existed in above-mentioned items between spontaneous preterm group and PROM group ( P>0.05). Iatrogenic preterm group had significantly lower gestational age (GA) and higher incidences of neonatal asphyxia and small-for-gestational-age (SGA) than PROM group ( P<0.05). Logistic regression analysis showed that iatrogenic preterm birth ( OR=1.983, 95% CI 1.037-3.791) and lower GA at delivery (34 weeks: OR=2.412, 95% CI 1.250-4.656; 35 weeks: OR =1.909,95% CI 1.197-3.044) were independent risk factors for CNAO in late preterm infants. Conclusions:In addition to immaturity caused by lower GA, iatrogenic preterm birth also increases the incidence of CNAO in late preterm infants.

Objective To study the changes in quantitative kinetic parameters in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) during radiotherapy and their value for efficacy evaluation in patients with nasopharyngeal carcinoma (NPC). Methods Twenty-four patients with NPC that had been pathologically confirmed as poorly differentiated squamous cell carcinoma underwent conventional MRI and DCE-MRI scans 1-2 days before radiotherapy (Pre-RT), during radiotherapy (RT 50 Gy), and upon completion of radiotherapy (RT 70 Gy). Based on the two-compartment model and using the arterial input function deconvolution technique, we calculated the quantitative kinetic parameters of DCE-MRI (Ktrans, kep, and Ve) of the tumor tissues, examined the correlation between the tumor regression rate (RS0-50) and the parameters on Pre-RT and RT 50 Gy, and compared the parameters for RT 70 Gy among the groups with different prognosis. Results The Ktrans value of the tumor tissue decreased after radiotherapy and showed a significant difference between Pre-RT and RT 70 Gy, but not between Pre-RT and RT 50 Gy. The kep value decreased and Ve value increased after radiotherapy. The tumor regression rate was found to be positively correlated with the Ktrans value for Pre-RT (P=0.005) but negatively with the Ktrans value for RT 50 Gy (P=0.001). During the follow-up for 3 years, 5 patients died and 3 patients had distant metastases. No statistical differences in Ktrans, kep, or Ve were found between the groups with different prognosis. Conclusions The kinetic parameters in DCE-MRI, which vary significantly during radiotherapy, allow monitoring of tumor angiogenesis and vascular permeability and quantitative assessment of treatment efficacy for NPC. Ktrans value for Pre-RT and RT 50 Gy can serve as an indicator for early efficacy assessment of radiotherapy and for treatment adjustment, but its relation with the long-term outcomes awaits further study.