Objective To analyze the clinical therapeutic efficacy of edaravone and dexborneol in elderly patients with posterior circulation perforating arterial cerebral infarction after receiving rt-PA for arterial thrombolysis.Methods A total of 68 elderly patients with acute cerebral infarction who were treated in our hospital from August 2021 to August 2023 were enrolled and then ran-domly divided into thrombolytic group and combined group,with 34 cases in each group.The thrombolytic group was treated with rt-PA arterial thrombolysis,and the combined group was treated with edaravone and dexborneol on the basis of thrombolytic group.The therapeutic effica-cy,neurological function,oxidative stress reaction,inflammatory reaction,ADL,and incidence of adverse events were compared between the two groups.Results There was no significant differ-ence in the total effective rate between the two groups(P＞0.05).Serum levels of NSE,MMP-9,S100β,MDA,IL-6 and CRP,and the scores of mRS and NIHSS were all decreased in the two groups in 14 d after treatment than before treatment(P＜0.05),and the levels of NSE,MMP-9,S100β,MDA,IL-6 and CRP,and mRS score and NIHSS score were obviously lower in the com-bined group than the thrombolytic group at the time point(P＜0.05,P＜0.01).After 90 days'treatment,the combined group obtained notably lower NIHSS score than the thrombolytic group(6.15±0.92 vs 7.48±0.83,P＜0.01).After 14 days of treatment,the level of SOD and Barthel in-dex in the two groups were higher than those before treatment(P＜0.05),and the two indicators in the combined group were higher than those in the thrombolytic group(P＜0.01).No statistical difference was observed in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Concurrent administration of edaravone and dexborneol shows good clinical ef-ficacy for elderly patients with cerebral infarction with perforating artery of posterior circulation after rt-PA arterial thrombolytic therapy,and at the same time,the combination of edaravone and dextromethorphan had a better clinical effect,which can reduce oxidative stress and inflammatory reaction,improve brain tissue damage and neurological function,and promote the ability of daily living,with better safety.

Objective To understand the stability of iodine content in potassium iodide iodized salt and potassium iodate iodized salt during production.Methods The sodium sulfate type brine well rock salt and calcium salt brine well rock salt as raw material were used to produce potassium iodide salt and potassium iodate salt by different iodization methods of before and after fluid bed dryer and then the loss of iodine during production was measured,meanwhile iodine content of powder salt was determined.According to the "Belt Delivery Sampling of Sampling Methods of the Main Products in the Salt Industry" (GB/T 8616-2001),25 standard salt samples and 6-24 powder salt samples were collected in the same batch.The salt iodine content was determined by oxidationreduction titration and direct titration of the "General Test Method in Salt Industry-Determination of Iodine" (GB/T 13025.7-2012).Results For the sodium sulfate type brine well rock salt,there was no statistical difference in iodine loss rate between potassium iodide salt and potassium iodate salt (16.55％ vs.19.60％,x2 =0.01,P ＞ 0.05) by iodization of before fluid bed dryer.The iodine loss rate of potassium iodide salt was 2.17％ and the iodine loss of potassium iodate salt was undetectable and there was no statistical difference between the two (x2 =2.19,P ＞ 0.05)by iodization of after fluid bed dryer.For calcium salt brine well rock salt,the iodine loss rate of potassium iodide was less than that of potassium iodate (20.60％ vs.39.75％,x2 =8.70,P ＜ 0.05) by iodization of before fluid bed dryer and neither of them was lost by iodization of after fluid bed dryer.Conclusions For both sodium sulfate type brine well rock salt and calcium salt brine well rock salt,the iodine loss of iodide iodized salt is not higher than that of potassium iodate during iodization of before or after fluid bed dryer.Since the iodine loss during iodization of before fluid bed dryer is significantly higher than that after fluid bed dryer,adopting iodization of after fluid bed dryer to produce iodized salt should be recommended.