Non-alcoholic fatty liver disease (NAFLD) has become a new health issue in the world due co its increasing incidence rate,and in particular,nonalcoholic steatohepatitis is progressive and has poor prognosis.Therefore,there is an argent need to search for the methods for the prevention of disease progression and treatment.Bile acid,as an important metabolite and signal molecule,can adjust the metabolism of lipids and carbohydrates and energy balance inside and outside the liver.Bile acid interacts with is receptors,such as the farnesoid X receptor and Takeda G-protein coupled receptor 5,bile acid transporter,and gut microbiota and is involved in the pathogenesis of NAFLD and nonalcoholic steatohepatitis at different levels.This article summarizes the research advances in the pathogenesis of bile acid-related NAFLD and related pharmacotherapy.

The alkaloids of Daphniphyllum angustifolium were investigated. The whole plant was extracted with 95% EtOH, six alkaloids were isolated and purified with column chromatography over silica gel, RP-18 and Sephadex LH-20. Based on spectral analysis, their structures were identified as daphnilactone B (1), zwitterionic alkaloid (2), yuzurine (3), dehydrodaphnigracilline (4), deoxyyuzurimine (5) and macrodaphniphyllidine (6). All of compounds were obtained from the plant for the first time.
Alkaloids ; analysis ; isolation & purification ; Drugs, Chinese Herbal ; analysis ; isolation & purification ; Magnoliopsida ; chemistry ; Plant Leaves ; chemistry

OBJECTIVETo study the chemical constituents of involatile moiety of Pogostemon cablin.

METHODCompounds were isolated and purified by repeated column chromatography, and their structures were elucidated by spectroscopic analysis.

RESULTNine compounds have been isolated and identified: epifriedelinol (1), 5-hydroxymethol-2-furfural (2), succinic acid (3), beta-sitosterol (4), daucosterol (5), crenatoside (6), 3'''-O-methylcrenatoside (7), isocrenatoside (8), and apigenin-7-O-beta-D-(6"-p-coumaryl)-glucoside (9).

CONCLUSIONCompounds 2, 3, 6-8 were isolated from Pogostemon genus for the first time.

Caffeic Acids ; chemistry ; isolation & purification ; Cholestenones ; chemistry ; isolation & purification ; Furaldehyde ; chemistry ; isolation & purification ; Glucosides ; chemistry ; isolation & purification ; Lamiaceae ; chemistry ; Molecular Structure ; Oils, Volatile ; analysis ; chemistry ; isolation & purification ; Sitosterols ; chemistry ; isolation & purification ; Succinic Acid ; chemistry ; isolation & purification