Objective To explore the factors influencing the patients' treatment compliance infected with chronic hepatitis B virus, and provide some useful advices to improve patients compliance. Methods Data were collected through deep interviews with 9 patients and analyzed using a phenomenological hermeneutic method. Results Using generic analysis, the factors influencing patients' compliance fell in-to three themes: (1) The enforceability of the doctor's advice; (2)The factors of the patients their own, in-cluding the disease-related knowledge, the realization of how harmful the disease is, and past behavior habits; (3)The social factors, including economic situation, pressure of life, family care, and the supervision and guidance of health care workers. Conclusions In order to make the patients consciously adopt the doctor's advice, health workers should pay more attention to strengthen the enforceability of the doctor's ad-vice and health education, and focus on the impact of cognitive, psychological and social factors on pa-tients' compliance.

Pain is one of the most common symptoms of tumors for cancer patients, especially those with advanced tumors. As a classic opioid that can relieve pain, morphine is widely applied in cancer patients. However, morphine has certain limitations in clinical application, for example, the long-term usage of morphine can result in analgesic tolerance and hyperalgesia, cause resistance to other chemotherapy drugs, and weaken the efficacy of chemotherapy drugs. When morphine is combined with some drugs, the adverse effects of morphine can be reduced. And the effect of morphine on tumor immunity, growth, metastasis, angiogenesis and apoptosis is also complex, and different concentrations and experimental models will have an impact on the efficacy of morphine, and the specific mechanism of these effects needs to be further explored. This paper reviews the characteristics, clinical use and the influence of morphine on cancer development.