Lichen nitidus (LN) is an uncommon, usually asymptomatic cutaneous eruption characterized by the presence of multiple, small, flesh-colored papules. The epidemiologic and pathophysiologic characteristics of LN have not yet been defined. Furthermore, LN has rarely been described in association with other cutaneous diseases. We herein report 3 cases of LN associated with various cutaneous diseases, including lichen striatus, oral lichen planus, and psoriasis vulgaris.
Lichen Nitidus* ; Lichen Planus ; Lichen Planus, Oral ; Lichens ; Mouth ; Psoriasis

Humans ; Lichen Planus, Oral ; psychology

No abstract available.
Lichen Planus, Oral* ; Mouth* ; Tacrolimus*

No abstract available.
Lichen Planus, Oral* ; Mass Screening*

Oral lichen planus (OLP) is a painful chronic inflammatory condition, that is often resistant to many therapeutic approaches, including immunosuppressive agents. Topical tacrolimus has recently been recognized as a safe and effective remedy in the treatment of OLP. We, rerein, describe 3 patients with oral lichen planus, who showed a substantial improvement after the use of topical tacrolimus ointment (0.1%). This topical agent was well tolerated in all 3 patients and could be used an effective medicine in controlling oral lesions of lichen planus.
Humans ; Immunosuppressive Agents ; Lichen Planus ; Lichen Planus, Oral* ; Tacrolimus*

Lichen planus is an unique, common inflammatory disorder that affects the skin, mucous membranes, nails and hair. Oral lichen planus is among the more common mucosal conditions with an unknown etiology. Lichen nitidus is an uncommon, usually asymptomatic cutaneous eruption that is characterized by the presence of multiple, small, flesh colored papules. Perforation in lichen nitidus is a rare phenomenon. Lichen nitidus is distinguished from lichen planus on both clinical and histologic grounds. However, the possibility that lichen nitidus represents a micropapular variant of lichen planus has never been definitively excluded. Herein, we report on a case of perforating lichen nitidus associated with oral lichen planus.
Hair ; Lichen Nitidus ; Lichen Planus ; Lichen Planus, Oral ; Lichens ; Mucous Membrane ; Nails ; Skin

Humans ; Lichen Planus, Oral ; diagnosis ; therapy

OBJECTIVETo evaluate the expression of CD4+, CD8+ T cells and cell apoptosis in oral lichen planus (OLP) and investigate the role and the relationship of immunological reaction and cell apoptosis in the pathogenesis of OLP2.

METHODSImmunohistochemical technique was used to study the expression of CD4+, CD8+ T cells in 27 OLP cases. TUNEL was used for detecting the cell apoptotic index (AI) in 17 OLP2 cases.

RESULTSThe expression of CD4+, CD8+ T cells were obviously elevated in lamina propria of OLP group compared with control group (P<0.05). There was a strong significance when compared the ration of CD4/CD8 in both group. AI was remarkably increased in epithelia cells and significantly decreased in lymphocytes in lamina propria in OLP cases compared with its expression in the control group respectively.

CONCLUSIONThe increased amount of CD4+, CD8+ T cells in lamina propria of OLP and the change ration of CD4/CD8 suggest that immune response is involved in the pathogenesis of OLP. The abnormal cell apoptosis plays an important role in the pathogenesis of OLP.

Oral lichen planus (OLP) is a relatively common chronic inflammatory disease of uncertain etiology. OLP lesions rarely undergo spontaneous remission and have the potential to undergo malignant transformation. The risk of malignant transformation in OLP is estimated to be between 0.4% and 5.3%; two clinical studies in Korea reported the frequency of malignant change as 2.9% and 2.85%. However, to the best of our knowledge, there has been no individual case report in the Korean dermatological literature to date regarding the malignant transformation of OLP. Herein, we report the case of a 77-year-old Korean woman with long-standing OLP that underwent transformation to oral squamous cell carcinoma. This is the first well-documented case report of squamous cell carcinoma that developed from OLP.
Aged ; Biopsy ; Carcinoma, Squamous Cell* ; Female ; Humans ; Korea ; Lichen Planus ; Lichen Planus, Oral* ; Remission, Spontaneous

oral lichen planus with epithelial dysplasia. It can be clinically mistaken for oral lichen planus, but has histologic features of dysplasia and a true malignant predisposition. It is not a variant or transitional form of lichen planus but, instead, represents a distinct entity that has a true potential for malignant transformation. In addition to abnormal epithelial maturation and cytology, lichenoid dysplasia exhibits other histologic features that separate it from oral lichen planus. Lichenoid dysplasia and lichen planus share many clinical and microscopic features, leading to the frequent misdiagnosis of unrecognized lichenoid dysplasia as lichen planus. We experienced a case of lichenoid dysplasia in the oral mucosa. We treated this patient with surgical excision. The patient has now been followed for two months. It is important to recognize this precancerous condition and inspect the excision site and remaining oral mucosa during long-term follow-up.]]>
Diagnostic Errors ; Follow-Up Studies ; Humans ; Leukoplakia ; Lichen Planus ; Lichen Planus, Oral ; Mouth Mucosa ; Precancerous Conditions