Objective To evaluate the accuracy of prenatal diagnosis of fetal conotruncal anomalies with echocardiography. Methods Fetal echocardiography were conducted for all women in their antenatal visits from Jan 2003 to Dec 2004. The echocardiographic diagnosis was compared with cardiac pathology results. Results Among 2063 women who had fetal echocardiographiy performed, conotruncal anomaly was detected in 28 fetuses with the average gestation of 26. 6 (16-40) weeks when the diagnosis was made, including tetralogy of Fallot (n=5), double outlet right ventricle (n = 6) , transposition of the great arteries (n = 5) , truncus arteriosus (n = 9) and ventricular septal defect with suspected overriding aorta (n=1). Four of the 28 fetuses were lost during follow up and the accurate rate of prenatal assessment of the great artery relationship was 75. 0% (18/24). Two fetuses with prenatal diagnosis of truncus arteriosus were reported as having pulmonary atresia with ventricular septal defect at autopsy. An overriding aorta was suspected in the other case, but postnatal echocardiography was diagnosed as perimembranous subaortic defect. Two fetuses with prenatally suspected double outlet right ventricle were diagnosed as having transposition of the great arteries at autopsy. Only one false-negative diagnosis was made in this series (4. 2%). Conclusions Conotruncal anomalies can be correctly diagnosed by fetal echocardiography. A combination of different views is necessary to define the exact spatial relationship of the great arteries. Specific diagnosis remains a challenge in some cases.

Objective To explore link of change of plasma C-reactive protein (CRP) and atrial fibrillation (AF). Method The hsCRP enzyme-linked immunosorbent assay (ELISA) methods were used to measure plasma CRP levels in 21 patients with lone paroxysmal AF (LPAF) during AF and 7 days after return to sinus rhythm ;28 patients with lone sustained atrial fibrillation(LSAF) and 27 patients with rheumatic heart disease and chronic AF(RHD).Levels of plasma CRP were compared to levels in 32 patients with paroxysmal supraventricular tachycardia(PSVT) and 20 voluntary healthy subjects. Results Patients with LPAF,LPAF and RHD had high levels of CRP when compared with PSVT and the healthy subjects.No significant changes of CRP levels were found between the onset AF patients and those after 7 days of recovery.Patients with lone persistent AF and rheumatic heart disease with persistent AF had higher levels of CRP than those with LPAF,but have no significance.There were positive correlation between the duration of AF and the levels of CRP.But there were no relation with left atrial size on echocardiography,sex and ages. Conclusion These results indicate that elevated CRP levels in AF patients may play an important role in the occurrence and sustainment of AF.

Objective To explore the effect of comprehensive nursing intervention on oral comfort in nasopharyngeal carcinoma patients undergoing radiotherapy .Methods Ninety-eight patients undergoing radiotherapy from December 2011 to June 2012 were chosen , and the control group including 50 patients who had undergone radiotherapy 30 times on the sixth week received the routing nursing interventions;95 patients undergoing radiotherapy from July 2012 to December 2012 were chosen , and the observation group including 50 patients who had undergone radiotherapy 30 times on the sixth week received the comprehensive nursing interventions .The self rating symptoms including dry mouth , sore throat , taste change and oral comfort level were compared in two groups .Results The cases of grade 0,Ⅰ,Ⅱ,Ⅲ,Ⅳradioactive oral mucositis in patients were respectively 7,15,20,8,0 cases in the observation group , and were respectively 1,6,29,13,1 cases in the control group, and the difference was statistically significant (Z=-2.872, P<0.05).The difference was found in the level of oral comfort in two groups (P<0.01).Conclusions Comprehensive nursing intervention can reduce the symptoms including dry mouth , sore throat, taste change in the patients with nasopharyngeal carcinoma radiotherapy , decrease the incidence of radioactive oral mucositis , and improve the level of oral comfort in patients .