Objective To investigate the influence of perimenopausal estrogen levels on the occurrence of osteoporosis. Methods From January 2014 to January 2016,106 cases of perimenopausal women in the Traditional Chinese Medicine Hospital of Shengzhou were selected in the study. According to the age,they were divided into two groups,with 53 cases in each group. The control group was aged from 45 to 50 years old. The observation group was 51 to 55 years old. The levels of serum estradiol (E2 ),β - collagen specific sequence (β - CTX),N - terminal osteocalcin (NMID),total type I collagen amino acid extended peptide (PINP) and bone mineral density (BMD) were compared between the two groups. Results The levels of E2 [(31. 56 ± 10. 33) ng/ L]and BMD[(80. 72 ± 24. 19) mg/ cm3 ] in the observation group were significantly lower than those in the control group[(73. 72 ± 13. 28) ng/ L,(125. 68 ± 38. 75) mg/ cm3 ](t = 18. 24,7. 17,all P < 0. 05). The levels of β - CTX,NMID and PINP in the observation group were (0. 29 ± 0. 04) ng/ mL,(24. 38 ± 11. 69) ng/ mL,(47. 66 ± 16. 88) μg/ L,respectively,which were significantly higher than those in the control group[(0. 17 ± 0. 01) ng/ mL,(11. 4 ± 2. 63) ng/ mL,(26. 79 ± 14. 42)μg/ L],the differences were statistically significant (t = 21. 19,8. 04,6. 84,all P < 0. 05). Conclusion The level of perimenopausal hormone in women is related to the occurrence of osteoporosis. With the decrease of estrogen level,the incidence rate of osteoporosis is increased,which is of great reference value for the prevention,diagnosis and treatment of disease.

Objective To investigate the effect of goserelin combined with marvelon in treatment of en -dometriosis(EM)and its effect on estrogen levels .Methods 120 EM patients were randomly divided into the ob-servation group(60 cases)and the control group(60 cases)according to the digital table.Two groups underwent laparoscopy .3.6 mg sustained release goserelin was injected subcutaneously from the anterior abdominal wall once every four weeks on the first time of menses recovery .The treatment continued during the following six months.The observation group were treated with marvelon on the basis of this , 1 tablet each day, 21 days of con-tinuous treatment and then began to take medicine on the 5 th day of the next menstruation during the following six months.The two groups were followed up for two years .The level of luteinizing hormone(LH), follicle-stimula-ting hormone(FSH)and estradiol(E2), the cumulative pregnancy rate, recurrence rate and peri menopausal sta-tus of the two groups were observed before and after treatment .Results The total effective rate was 96.67%and 83.33%respectively for the observation group and the control group .The difference had statistical significance (P<0.05).The level of E2, FSH, and LH at 1 month, 3 months, 6 months after treatmnet was lower than that before treatment(P<0.05).The level of E2, FSH, LH of two groups had no statistical difference (P<0.05). The cumulative pregnancy rate of the observation group was higher than that of the control group while the recur -rence rate was lower than that of the control group ( P<0.05 ) .The perimenopausal symptom score ( Kupperman score)of the two groups had no significant difference (P>0.05).Conclusion Goserelin combined with marvel-on can effectively improve the effect of laparoscopic surgery in treatment of endometriosis , lower estrogen level , improve patients'pregnancy rate , and reduce the recurrence rate .