Forkhead box O (FOXO) transcription factors are involved in multiple signaling pathways and play critical roles in a number of pathological and physiological processes including proliferation and apoptosis, so this family of transcription factors appears to be a promising target for future drug discovery for cancers.This review presents the research progress of FOXO proteins as a target for cancer therapy.

Objective To observe the clinical effect of Baiziyangxin decoction in treating children's viralmyocarditis and to explore its possible mechanism. Methods Sixty-two patients were randomly divided into a control group and a treatment group. The control group was treated with conventional western therapy (CWT), while the treatment group was treated with CWT plus Baiziyangxin decoction. The changes of myocardial enzymes before and after the treatment were observed. Results The total effective rate of the treatment group was 87.5%, while that of the control group was 70%. The difference of the total effective rate between the two groups was significant(P<0.05)., The treatment group was obviously superior to the control group in declining myocardial enzymes level. Conclusion Baiziyangxin decoction showed obvious effect in treating Children's Viralmyocarditis.

Objective To set up a method for determining Specnuezhenide in Shengxinfa Capsules. Methods With HPLC method, Agilent TC-C18 column (4.6 mm×250 mm, 5 μm) was used. Mobile phase was methanol-water (35∶65), the flow rate was 1.0 mL/min, and the detecting wavelength was at 224 nm. Results The linearity was in the range of 0.15-0.90 μg. The average recovery was 100.35%, and RSD was 1.43%. Conclusion The method is accurate, reliable, and can be used for the determination of Specnuezhenide in Shengxinfa Capsules for its quality control.

Objective To establish the fingerprint for evaluation of Zhenhuang Capsules (Scutellaria Extract, Notoginseng Radix et Rhizoma, et al). Methods The fingerprint was established by HPLC with photodiode array detector (PADA). The mobile phase was methanol-0.1%phosphoric acid (gradient elution), column temperature was at 35 ℃, flow rate was 1.0 mL/min, and detection wavelength was at 280 nm. Results There were 15 common peaks appeared in the HPLC-PADA fingerprint which was defined by Similarity Evaluation System for Chromatographic Fingerprint of TCM (Version 2004A) published by Committee of Pharmacopoeia of China. The similarity of 11 batches examples with the control was more than 0.99. Conclusion The method is simple, accurate and sensitive, with good reproducibility. It is suitable for quality evaluation of Zhenhuang Capsules.

Objective To observe the clinical effects of Chaihu Gegen decoction in treating children's epidemic parotitis and to explore its possible mechanism. Methods Sixty five patients were randomly recruited into a control group and a treatment group. The control group was treated with conventional western therapy (CWT) , while the treatment group was treated with CWT plus Chaihu Gegen decoction and external application of Chinese medicine. The therapeutic effects in both groups were observed. Results The body temperature and the improvement time of clinical symptoms were obviously better in treatment group than the control group. The effective rate was 94.29% and 76.67% in the treatment group and the control group respectively. The difference between the two groups was significance (P<0.05). Conclusion It is effective to treat epidemic parotitis with Chaigu Gegen decoction combined with external treatment.

Objective To understand the basic information and differences in the AIDS-related knowledge ,attitude ,behavior and knowledge acquisition between the medical students and the non-medical students to provide the related basis for formulating the ra-tional health education strategy in the colleges and universities .Methods The questionnaires of the AIDS-related knowledge ,atti-tude ,behavior and knowledge acquisition were used to perform the survey on 440 college students including 220 medical students and 220 non-medical students .The SPSS19 .0 software was adopted to analyze the survey results .Results The statistical differ-ences existed between the the medical students and the non-medical students in the average scores of the AIDS-related knowledge and attitude questionnaires(P<0 .05) .The propability of premarital sexual behavior was 3 .96% in the medical stedents and 7 .62%in the non-medical students .The main routes for obtaining the AIDS knowledge in the medical students and the non-medical students were newspapers ,magazines ,televisions and movies .The most popular routes were televisions and movies .Conclusion Colleges and universities should team up with families for conducting the AIDS education through the way that the college and uni-versity students really enjoy ,especially for the non-medical students on the non-transmission route knowledge ,the attitude towards the patients/infected individuals with AIDS and the prevention knowledge .

Objective: To study the effect of low-dose dopamine on splanchnic DO_2/VO_2.in rabbit SMAO shock Method:Twenty rabbits were randomly devided into two groups:group A with dopamine,group B as control group. In group A dopamlne was infused at a rate of 5?g?kg~(-1)?min~(-1). SMAO shock model was induced in both groups. Cardiac output index(Cl),portal venous blood flow index (QpvI),mean arterial pressure (MAP),arterial. artiaI and portal venous blood gas analysis.arterial and portal venous serum lactate concentrations(ALT,PLT), total oxygen delivery/oxygen consumption (TDO_2/TVO_2), splanchnic oxygen delivery/oxygen consumption (SDO_2/SVO_2). oxygen extraction ratio(O_2ER) were measured respectively. Result: QpvI, SDO_2,SVO_2 were higher in group A than those of group B (P0.05). CI,MAP, TDO_2/TVO_2 decreased. TO_2ER and SO_2ER increased in both of groups during shock, but without significant differences between both groups. Conclusion: Low-dose dopamine has beneficial effects by increasing portal venous blood perfusion and improving splanchnic oxygenation during SMAO shock in rabbits. but no effects on systemic oxygenation of shock.

Objective To investigate the effect of unilateral basal ganglia hemorrhage on long -term behavio-ral development of neonatal SD rats.Methods Forty -eight neonatal SD rats (1 0 days after birth)were equally divided into cerebral hemorrhage (CH)group,sham operation (SH)group and normal control (NC)group randomly, 1 6 cases for each group.Stereotaxic apparatus was used to inject autologous blood 25 μL into rats′brain caudate nu-cleus to establish basal ganglia hemorrhage model,while SH group was injected with nothing,and NC group received no treatment.Berderson scoring method was used to test rats′neurological functions on the first day,the third day,the seventh day,and the fourteenth day after operation,respectively.The open -field environment test and the Lat maze were used to assess behavior of the rats on the fourteenth day after operation,lasting for 3 days continuously.Results (1 )After being modeled rats appeared with different degrees of neurological function damage.SH group rats′neurologi-cal function damage was slight,which was completely restored in the 72 hours after surgery.CH group rats appeared hemiplegia and muscle tension change.CH rats neurological scores′on the first and third day after modeling scores were separate (3.40 ±0.83)scores and (1 .1 3 ±0.92)scores respectively,and the scores were statistically higher than SH group [(0.73 ±0.59)scores and (0.1 3 ±0.35)scores]and NC group (all P <0.05).And then Bederson score de-creased,and on the seventh and fourteenth day after modeling,the Bederson scores′difference was not statistically sig-nificant among the 3 groups(P >0.05).(2)On the fourteenth day after modeling,in open -field test and the Lat maze,the number of passed panels,straightening(times)and grooming(times)in CH group were more than those in SH group and NC group respectively (all P <0.05).The difference in the number of passed panels,straightening (times)and grooming (times)between SH group and NC group was not statistically significant (P >0.05 ). Conclusions Neonatal rats focal hemorrhage in unilateral basal ganglia is strongly repairable and compensatory,which leaves no severe neurological dysfunction.The neurological function damage which is caused by unilateral basal ganglia hemorrhage can lead to the increase of autonomic activities,the decrease of non -selective attention level,attention defi-cit and other long -term behavioral abnormalities.

BACKGROUND:It has been found that the compressive strength and flexural strength of nano-hydroxyapatite combined with light-cured resin matrix can neet the requirements of dental restorative materials. OBJECTIVE:To detect the cytotoxicity of nano-hydroxyapatite/composite resin, and to analyze its effects on the dental restoration. METHODS:In vitro test:passage 5 periodontal ligament fibroblast-like cel s and L-929 cel s suspensions were cultured in the 10%, 50%, 100%of nano-hydroxyapatite/composite resin extracts, respectively, and fresh maintenance medium functioned as negative control group. Absorbance values were detected within 7-day culture. In vivo repair test:57 cases with tooth defect were enrol ed containing 37 males and 20 females aged from 15 to 31 years old, and al were subjected to nano-hydroxyapatite/composite resin treatment. A 3-year fol ow-up was undergone to detect the completeness, marginal adaptation and color matching of the restoration, as wel as the periodontal probing depth, sulcus bleeding index, tooth mobility, dental plaque index, gingival crevicular fluid and aspartate aminotransferase level. RESULTS AND CONCLUSION:In vitro test results showed that the different concentrations of nano-hydroxyapatite/composite resin extracts had no effects on both periodontal ligament fibroblast-like cel s and L-929 cel s. In vivo repair test results found that after 3 years of fol ow-up, the periodontal probing depth, sulcus bleeding index, tooth mobility, dental plaque index, gingival crevicular fluid and aspartate aminotransferase level of patients were significantly decreased than those before repair (P<0.05), but the alkaline phosphatase level revealed no significant change (P>0.05). Unfortunately, three cases with incomplete restoration, four cases with color mismatching, and three cases with the inadaptable edge occurred. To conclude, the nano-hydroxyapatite/composite resin holds good biocompatibility and no cytotoxicity, which can maintain a good periodontal health condition in the dental restoration.

OBJECTIVE:To investigate therapeutic efficacy and safety of Salviae miltiorrhizae and ligustrazine hydrochloride injection in the treatment of vertebro-basilar artery insufficiency(VBI)after cerebral infraction. METHODS:128 patients with VBI after cerebral infraction were divided into observation group and control group according to random number table,with 64 cases in each group. Both group received general treatment. Control group was additionally given Shuxuetong injection 6 ml added into 0.9%Sodium chloride injection 250 ml,ivgtt,qd. Observation group was additionally given Salviae miltiorrhizae and ligustrazine hy-drochloride injection 10 ml into 0.9% Sodium chloride injection 250 ml,ivgtt,qd. Both groups received treatment for consecutive 2 weeks. Clinical efficacies of 2 groups were observed as well as blood lipid,vertebro-basilar artery blood velocity and blood viscosity before and after treatment. The occurrence of ADR was compared between 2 groups. RESULTS:The total effective rate of observa-tion group was 95.31%,which was significantly higher than 79.69% of control group,with statistical significance(P<0.05). Before treatment,there was no statistical significance in blood lipid,vertebro-basilar artery blood velocity and blood viscosity between 2 groups(P>0.05). After treatment,above indexes of 2 groups were improved significantly,and blood lipid and vertebro-basilar ar-tery blood velocity of observation group were significantly better than control group,with statistical significance(P<0.05). No obvi-ous ADR was found in 2 groups. CONCLUSIONS:Salviae miltiorrhizae and ligustrazine hydrochloride injection shows significant therapeutic efficacy for VBI after cerebral infraction,can significantly improve blood lipid,vertebro-basilar artery blood velocity and blood viscosity with good safety.