Objective:To investigate the status of family function and self-management in patients with chronic kidney disease in the early stage, and to analyze the correlation between the two.Methods:From May 2018 to November 2019, 242 early stage patients with chronic kidney disease in the Department of Nephrology of the Second Affiliated Hospital of Guangxi Medical University were selected as the research subjects. The family function assessment scale and self-management scale were used for investigation.Results:The average scores of family function in early stage of chronic kidney disease patients were (2.11±0.37) points, and the average scores of self-management were (2.29±0.63) points; family function was negatively correlated with self-management ( r value was -0.832, P <0.05). Multiple linear regression analysis showed that education level and family function were influencing factors of patient self-management ( t value was 15.916, 17.569, P <0.05). Conclusions:The family function and self-management of patients with chronic kidney disease need to be improved in the early stage. Family function can affect patients' self-management. Nursing staff should focus on the functions of communication and behavior control in the family functions of patients with early chronic kidney disease in order to improve their self-management ability.

Objective To investigate the impact of preoperative hyperuricemia on acute kidney injury (AKI) after cardiac surgery with cardiopulmonary bypass (CPB).Methods A total of 567 adult patients undergoing cardiac surgery with CPB were enrolled to conduct a retrospective cohort database analysis.The patients were divided into hyperuricemia group and non-hyperuricemia group according to preoperative serum uric acid,and the incidence of AKI in two groups were compared.Binary logistic regression analysis was used to evaluate the relationship between preoperative hyperuricemia and AKI.Results Among 567 patients after cardiac surgery with CPB,hyperuricemia occurred in 303 cases (53.4％),and AKI occurred in 217 cases (38.3％).There was significantdifference in the incidence of AKI between hyperuricemia group and non-hyperuricemia group (44.6％ vs 31.1％,x2=10.874,P=0.001).The duration of intensive care unit (ICU) stay and the length of stay were longer in hyperuricemia group than those in non-hyperuricemia group (both P ＜ 0.05).After adjusting for age,gender,comorbidities (hypertension,diabetes mellitus,cerebrovascular disease),preoperative renal function,preoperative heart function,CPB time,intraoperative aortic block time,type of cardiac surgery and postoperative hypotension,binary logistic regression analysis showed that preoperative hyperuricemia was an independent risk factor of AKI after cardiac surgery with CPB (OR=1.912,95％ CI 1.270-2.879,P=0.002).Conclusion AKI is a common complication following cardiac surgery with CPB,and hyperuricemia is independently associated with CPB-associated AKI.Hyperuricemia may be involved in the pathogenesis of AKI,and intervention before cardiac surgery may be beneficial to prevent postoperative AKI.