Necroptosis,it is activated by the formation of necrosome,is a way of programmed cell death that independent of the activation of caspase.Necroptosis is regulated by many factors,for example,RIPK1 can initiate necroptosis,but also inhibit necroptosis;caspase-8 is the key negative regulation factor of necroptosis;CHIP is a new regulation protein of necroptosis.Triggering necroptosis is a promising strategy to overcome apoptosis resistance in cancer.

Objective:To summarize the content and effects of exercise interventions for stroke survivors, providing references for medical and nursing personnel in formulating exercise intervention plans for these patients.Methods:Literature on exercise interventions for stroke survivors was searched in databases such as China National Knowledge Infrastructure, Wanfang, VIP, China Biology Medicine disc, Cochrane Library, PubMed, Embase, and Web of Science up to May 1, 2023. Data extraction and summarization were conducted on the included literature.Results:Twenty-two articles were included in the review. The exercise types for stroke survivors primarily involved aerobic and resistance training; the intensity was mainly moderate to high; the frequency was mostly 3-5 times per week, with each session lasting 30-60 minutes; and the duration of interventions ranged from as short as two weeks to as long as one year. Exercise interventions improved stroke survivors' functional mobility, quality of life, cardiopulmonary function, mental state, cognitive function, fatigue, sleep, and compliance to varying degrees.Conclusions:Exercise interventions have achieved positive outcomes in stroke survivors. In the future, medical and nursing personnel can incorporate patient preferences into exercise intervention plans while ensuring patient safety to promote rehabilitation.

Objective:To explore the chain mediating effect of emotion dysregulation and trait anger between childhood trauma and aggressive behavior in adolescents.Methods:A sample of 1 333 undergraduates were recruited to complete the questionnaires about childhood trauma, aggressive behavior, emotion dysregulation, trait anger.The SPSS 23. 0 and Mplus 8.3 software were used to analysis data and test intermediate effect.Results:The scores of childhood trauma, aggressive behavior, difficulties in emotion regulation and trait anger were (33.624±8.211), (53.995±12.307), (91.781±17.518), (23.352±5.477), respectively. Correlation analysis showed that childhood trauma, aggressive behavior, emotion dysregulation and trait anger were positively correlated with each other( r=0.209-0.614; all P<0.01). Mediation modeling analysis showed that childhood trauma had a significant direct effect on aggressive behavior. The direct effect value was 0.121, accounting for 35.8% of the total effect. The total indirect effect of childhood trauma on aggressive behavior was 0.217, accounting for 64.2% of the total effect. The mediating effect of emotion dysregulation as mediator between childhood trauma and aggressive behavior was 0.035, accounting for 10.4% of the total effect. The mediating effect of trait anger as mediator between childhood trauma and aggressive behavior was 0.108, accounting for 31.9% of the total effect. The chain mediating effect of emotion dysregulation and trait anger was 0.074, accounting for 21.9% of the total effect. Conclusion:Emotion dysregulation and trait anger exert a multiple mediating effect on the relationship between childhood trauma and aggressive behavior.

Objective To investigate the current status and influencing factors of physical activity(PA)among stroke survivors.Methods A total of 203 stroke survivors were selected as the research subjects using convenient sampling method.General information questionnaire,Stroke Self-efficacy Scale,Perceived Social Support Scale,Modified Rankin Scale,International Physical Activity Ques-tionnaire-Long Form,Fatigue Severity Scale,and European Five-Dimension Health Scale were used for questionnaire survey.Based on the health ecological model,hierarchical multiple linear regression a-nalysis was used to explore the influencing factors of PA among stroke survivors.Results Using meta-bolic equivalents(MET)to quantify energy expenditure,the weekly PA energy expenditure of 203 stroke survivors was 693.0(0,1 386.0)MET.The results of hierarchical multiple linear regression analysis showed that personal traits(stroke staging),behavioral characteristics and psychology(Mod-ified Rankin Scale score,fatigue severity,stroke recovery self-efficacy),and interpersonal networks(perceived social support-friend support dimension)were the main influencing factors of PA among stroke survivors(P＜0.05),which could explain 55.5％of the variation in PA.Conclusion The level of PA among stroke survivors is influenced by multi-dimensional and multi-level complex factors in their health ecosystem,and it is currently at a low level.Healthcare professionals can formulate comprehensive strategies to improve PA among stroke survivors based on the health ecological model,aiming to further enhance the PA level of stroke survivors and promote physical function recovery.

Objective To investigate the current status and influencing factors of physical activity(PA)among stroke survivors.Methods A total of 203 stroke survivors were selected as the research subjects using convenient sampling method.General information questionnaire,Stroke Self-efficacy Scale,Perceived Social Support Scale,Modified Rankin Scale,International Physical Activity Ques-tionnaire-Long Form,Fatigue Severity Scale,and European Five-Dimension Health Scale were used for questionnaire survey.Based on the health ecological model,hierarchical multiple linear regression a-nalysis was used to explore the influencing factors of PA among stroke survivors.Results Using meta-bolic equivalents(MET)to quantify energy expenditure,the weekly PA energy expenditure of 203 stroke survivors was 693.0(0,1 386.0)MET.The results of hierarchical multiple linear regression analysis showed that personal traits(stroke staging),behavioral characteristics and psychology(Mod-ified Rankin Scale score,fatigue severity,stroke recovery self-efficacy),and interpersonal networks(perceived social support-friend support dimension)were the main influencing factors of PA among stroke survivors(P＜0.05),which could explain 55.5％of the variation in PA.Conclusion The level of PA among stroke survivors is influenced by multi-dimensional and multi-level complex factors in their health ecosystem,and it is currently at a low level.Healthcare professionals can formulate comprehensive strategies to improve PA among stroke survivors based on the health ecological model,aiming to further enhance the PA level of stroke survivors and promote physical function recovery.

ObjectiveTo compare the differences in thyroid hormone levels between adolescents with and without suicidal ideation， and to explore the association between thyroid hormone/suicidal ideation and the antidepressant treatment. MethodsA total of 100 patients were divided into non-suicidal ideation group and suicidal ideation group according to the SIOSS. The levels of thyroid-stimulating hormone （TSH）， triiodothyronine （T3）， thyroxine （T4）， free triiodothyronine （FT3） and free thyroxine （FT4） were compared between the two groups as well as their changes after 6 weeks of antidepressant treatment. ResultsThe levels of FT3， FT4 and T4 in the non-suicidal ideation group were higher than those in the suicidal ideation group. After 6 weeks of antidepressant treatment， the levels of FT3， FT4 and T4 in the suicide ideation group were higher than those before the treatment. The FT3 level in the male non-suicidal ideation group was higher than that in the suicidal ideation group. The levels of FT4 and T4 in the female non-suicidal ideation group were higher than those in the suicidal ideation group （all P<0.05） ConclusionThere are differences in thyroid hormone levels between adolescents with and without suicidal ideation （both with first-episode depression）， and patients with suicidal ideation have significant changes after treatment with antidepressants.