To explore the effect of the intervention of clinical pharmacists on the rational use of potassium magnesium aspartate . Methods:The prescriptions of outpatients in the fourth quarter of 2013 and those of emergency in the second quarter of 2014 with potassium magnesium aspartate injection were collected and analyzed. The unreasonable use rate of the drug before and after the intervention was compared. Results:The unreasonable use rate of potassium magnesium aspartate before the intervention was 35. 4%, that after the intervention was 15. 8%, and the difference was statistically significant(P<0. 01) . The difference in beyond the indica-tion, high concentration and unreasonable compatibility of the drug before and after the intervention was statistically significant ( P<0. 01 or P<0. 05) . Conclusion: The intervention of clinical pharmacists in the use of potassium magnesium aspartate is effective, which should be performed continuously.

Objective To explore the expression of cyclooxygenase-2 (COX-2) in different epidermal tumors and its significance. Method The expression of COX-2 was detected by immunohistochemical staining of skin specimens from 10 cases of basal cell carcinoma (BCC), 8 squamous cell carcinoma (SCC), 8 Bowen′s disease (BD), 12 seborrheic keratosis (SK) and 10 normal volunteers. Results Compared with normal epidermal cells, COX-2 expression was significantly increased in BCC, SCC and BD cells. Especially, COX-2 expression in SCC was the most intensive. COX-2 expression in SK cells was similar to that of normal epidermal cells. Conclusion The up-regulation of COX-2 expression may play a potential role in the pathogenesis of epidermal tumors.