Objective? To investigate the effect of midline catheter in intravenous treatment after renal transplantation. Methods? From May 2018 to February 2019, 84 renal transplant patients were treated with central line catheters, which were placed through cubital fossa or superior superficial cubital vein. The length of catheters was 22-36 cm. During catheterization, the maintenance of catheters was well done, the prevention and treatment of complications were emphasized, and the situation of catheter extraction was observed. Results? Totally 84 patients had catheter indwelling time of 10-41 days, 2 cases of puncture point oozing, 2 cases of tube plugging, 2 cases of shoulder pain, 1 case of upper extremity edema. After careful care and treatment, no serious complications occurred and the effect was satisfactory. Conclusions? The application of midline catheter vein treatment, without repeated venipuncture, reduces the pain of patients′ puncture and the occurrence of phlebitis, achieves the expected treatment effect, and reduces the workload of nurses.