OBJECTIVE: To investigate the role and clinical significance of the expression of BRMS1 gene in development and progression of nasal and paranasal sinus carcinomas. METHOD: The expression of BRMS1 protein was detected by immunohistochemistry method in the 53 nasal and paranasal sinus carcinomas and 24 nasal polyp tissues and 10 normal mucosa. The expression of BRMS1 was analyzed in nasal and paranasal sinus carcinomas with different clinicopathological parameters. RESULT: The expression of BRMS1 in normal tissues (90.0%) and nasal polyp tissues (79.2%) was statistically significantly higher than that in nasal and paranasal sinus carcinomas (39.6%) (P < 0.01). There was a positive correlation between BRMS1 expression and TNM staging and lymph node metastasis; but not associated with pathological grade. CONCLUSION The loss of BRMS1 expression may be involved in the development and progression of nasal and paranasal sinus carcinomas.
Adult ; Aged ; Female ; Genes, Tumor Suppressor ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Proteins ; genetics ; Neoplasm Staging ; Nose Neoplasms ; genetics ; pathology ; Paranasal Sinus Neoplasms ; genetics ; pathology ; Repressor Proteins