OBJECTIVE: To study the effect of insulin injection on the stability of cefodizime sodium for injection in 5% glucose injection.METHODS: The appearance and the pH value of the mixed solution in 12 h were monitored and the content of cefodizime sodium in the mixed solution was determined by HPLC.RESULTS: There were no evident changes for the mixture in appearance,pH value and the content of cefodizime sodium within 12 h at room temperature.CONCLUSION: Insulin injection has no effect on the stability of cefodizime sodium within 12 h at room temperature.

Objective To develop a HPLC method for psoralenand angelicin content assay in Zhuanggu granules .Meth-ods Agilent Zorbax C18 column(4 .6 mm × 250 mm ,5 μm) was used with methanol and water (45∶55) as mobile phase .The detection wavelength was set at 245 nm .The flow rate was 1 .0 ml/min and column temperature at 25 ℃ .The injection volume was 10 μl .Psoralenand angelicin were extracted with 70% ethanol under water bath .Results The linearity was obtained over 3 .75~40 μg/mlfor psoralenand angelicin .The RSDs were less than 2% .The average recovery was between 94% and 105% . Conclusion This simple and accurate HPLC method was suitable for the quality control of Zhuanggu granules .

Objective To provide basic references for the utilization of health educational prescription in community and to evaluate the intervention effects of health educational prescription in child vaccinoprophylaxis. Methods A total of 1055 participants ( age ranged from 1-24 months ) along with their parents were recruited from the community received routine health education about vaccinoprophylaxis. Participants were randomly divided into control group (n=495) and intervention group (n=560). All parents in the control group received the conventional health education, while parents in the intervention group received the additional health education prescription based on the conventional health education. The rate of adverse reaction of vaccinoprophylaxis in children and the satisfaction level in parents for health care were compared between two groups after six months′ interventions. Results The incidence rate of adverse reaction in the intervention group were lower than that of the control group (P<0. 01). The satisfaction level of parents in the intervention group was 97. 3% and was 90. 9% in the control group (χ2 =4. 24,P<0. 05). Conclusions The health educational prescription can reduce the incidence of adverse reaction in children and improve the satisfaction level in parents. It is worthy of promotion in community child vaccinoprophylaxis.