Objective To explore the cinical significance of Plasma Endothelin-1(ET-1) and Nitrous Oxide(NO) in the children associated with left to right shunt congenital heart defect(CHD) with Pulmonary Hypertension(PH).Methods 42 children associated with left to right shunt congenital heart defect with pulmonary hypertension(as patient's group),26 children associated with left to right shunt congenital heart defect without pulmonary hypertension(as heathly group),20 children had the checkup(as control group).Plasma ET-1 and NO2+/NO3+ was cletected in all groups by radioimmunoassay and nitric acid-restored method.Results ET-1 of patient's group was significantly higher than that of control group(P0.05);NO2+/NO3+ of that was significantly lower control group(P

Objective To research the way of micro-traumatic ligation of PDA.Methods 40cases of PDA patient were ligated at auscultation triangle for PDA and the results were compared with 20cases of the passing chest methods.Results The results of new method were better than those of usual ligation in many studies.Conclusions This method could be used for all PDA patients except the patient combined with pulmonary hypertension or second operation and other cardic deformity.