Objective To investigate the effects of health education on enhancing the compliance behavior of patients with diabetes mellitus (DM). Methods 63 DM patients were provided with systemic health education during their staying in the hospital. A follow-up interview was performed at the 6th month of discharge to gather the information of how importance of compliance behavior on the prognosis of DM. Result After the systemic health education, the patients could take medicine on time and had a good behavior in daily life, which will effectively improved their quality in the future life.Conclusion Systemic the health education can improve the compliance behavior of patients, and thus directly affects the prognosis of DM.