With life level improving, more and more attention has been paid to the health and subhealth. Although the thoughts of prevention the diseases had been raised in Yellow Emperor’s Inner Canon and gave the direction of Chinese Medicine in interventing in subhealth condition, and the dominance of Chinese Medicine in interventing in subhealth condition in clinic has been generally accepted by the specialists, the key problem about the concepts of the health, subhealth, before sickness and prevention have not unified standards. According to the Clinical Guidelines of Chinese Medicine on Subhealth which was published by China Association of TCM and Pharmacy, the author gave personal opinions and wished to discuss them with all experts.

Japanese kampo medicine originated from traditional Chinese medicine. But different from TCM pattern of "Tracing the etiology by syndrome differentiation-establishing therapeutic methods-prescribing formula", during the process of development, Japanese kampo medicine has gradually formed a different diagnostic and therapeutic mode, which was "corresponding prescription and pattern". This therapeutic mode directly chose formula from ancient books, especially Shanghanlun (Treatise on Febrile Diseases), according to the constitution, symptoms and signs of patients. The diagnostic and therapeutic mode of Japanese kampo medicine provides references for integration of traditional Chinese and western medicine.

This article introduced the treatment of chronic renal insufficiency by by retention enema with Chinese medicine, and analysed its mechanism and the application status quo. It explorated the way to delaying the development of chronic renal insufficiency patients into the blood or peritoneal dialysis process positively.

Objective To study the effect of Gualou Gancao Granules(GLGC)on influenza virus pneumonia mice.Methods The mice model of viral pneumonia was established by nose inhalation of influenza virus FM1.The treatment groups were administered GLGC with ribavirin served as control drug.The mortality,body weight,lung index,viral blood agglutination titer of influenza virus pneumonia mice were observed.Results Compared with the model group,GLGC can reduce the mortality of influenza virus pneumonia mice,prolong the average living days,inhibit the body weight decrease,and depress the lung index and viral titer distinguishingly.Conclusion GLGC,which derived from the therapeutic principle of clearing away heat-evil and eliminating sputum,has an affirmative effect on influenza virus pneumonia mice.

Objective: To study the effect of Tang Ke Decoction on tumor necrosis factor ?(TNF?) and glucose transporter 4(GLUT4) expression in tissues of model rats of insulin resistance of type two diabetes mellitus,and to investigate the mechanism of the function of Tang Ke Decoction to insulin resistance.Methods: Rat model of insulin resistance of type two diabetes mellitus was duplicated by using strepozotocin(STZ) and high caloric diet,and using Tang Ke Decoction of compound Chinese herbs and rosiglitazone acted on model rats individually.The degree of insulin resistance was measured by insulin sensitivity index(ISI).The expression of TNF? mRNA was assayed in adipose tissue by RT-PCR.GLUT4 protein expression was assayed by immunohistochemical method in skeletal muscule tissue,and its distribution in skeletal muscle cell was observed with electron microscope.Results: ISI of model group was significantly lower than that of control group(P

Idiopathic pulmonary fibrosis is divided into chronic progression stage and acute exacerbation stage according to progression of disease;early,middle and late stage according to onset time and clinic symptoms.It is considered that the etiological factors of idiopathic pulmonary fibrosis are repeated suffering of exogenous pathogen,environmental pathogen, deficiency of lung and kidney.The basic pathological products are blood stasis and phlegm turbid,the key point of pathopoiesis is that phlegm and stasis hides deeply and stagnated,the pulmonary collaterals are blocked.In addition,the evolutions of pathogenesis during its different stage are discussed.

OBJECTIVE: To study the approach for developing a rat model of pulmonary fibrosis induced by bleomycin (BLM). METHOD: Different doses (7, 6, 5, 3.4, 2, 1 mg/kg) of bleomycin A5-saline were infused into the rats' lung in bleomycin-treated group through tracheal intubation, and rats in sham-operated group were infused with same volume of saline. The living state and lung pathology of the rats were observed. The author deeply studied the condition of the rats in 1 mg/kg bleomycin-treated group, and the changes of body weight and lung pathology were observed. Lung quotient, the content of transforming growth factor beta1(TGF-beta1) and platelet-derived growth factor (PDGF) in serum were measured on the 14th, 28th and 45th day of the experiment. RESULTS: The study demonstrated that infusing large doses of bleomycin A5 quickly through tracheal intubation had a high mortality, and infusing 1 mg/kg quickly could successfully develop an animal model of pulmonary fibrosis. Compared with the sham-operated group, fibrosis was appeared obviously in the rats' lung in 1 mg/kg bleomycin A5-treated group after 14 days of experiment, diffuse fibrosis was appeared after 28 days of experiment, and the fibrosis became more severe after 45 days of experiment. The body weight of the rats in bleomycin-treated group was declined after 3, 7 and 14 days of experiment as compared with the sham-operated group (P<0.01). Twenty-one days after the experiment, the body weight was declined too, but there was no significant difference between the bleomycin-treated group and the sham-operated group (P>0.05). Lung quotient was increased 14, 28 and 45 days after the experiment (P<0.01), the level of serum TGF-beta1 began to increase since 28 days after the experiment (P<0.05, P<0.01), and the level of serum PDGF also increased gradually 45 days after the experiment (P<0.05). And the mortality rate of 1 mg/kg bleomycin A5-treated group was lower than those of the other doses of bleomycin A5-treated groups. CONCLUSION: A rat model of pulmonary fibrosis can be duplicated successfully by infusing 1 mg/kg bleomycin A5 quickly through tracheal intubation.

Doctors in the past dynasties always used ephedra to treat disease of exogenous wind-cold,cough,asthma and edema,but ignored its application in treating arthromyodynia.It could be deduced from the record of the books of Chinese medicine and prescriptions that ephedra had the nature of pungent and warm,could dispel wind and remove wetness,warm channel and expel cold,remove obstruction in collaterals.All of those were correspondent with the pathogenesis of arthromyodynia.Thus,ephedra can be widely used in types of arthromyodynia.Proven case was also included in this article.

Objective:To research the therapeutic effect dnd pulmonary ground substance rebuilding in the treatment on IPF patients by Feixian-Fang and.Methods:Treatment 20 cases IPF by Feixian Fang RCT prednisone three months.obsive The therapeutic efficacy and the levels of matrix met alloproteinase 1,2,tissue inhibtor of met alloproteinase(TIMP-1,2).Results: The total effective rate of Feixian-Fang group is 84.2%.The total effective rate of prednisone group is 81.3%.Feixian-Fang can reduce the level of MMP-1,MMP-2,TIMP-1,TIMP-2 in the serum.Concluds:Feixian-Fang can treat IPF probably through inhibiting pulmonary ground substance rebuilding.