1.Clinical value of human papillomavirus genotype distribution in HPV infection
Ying JIA ; Min ZHOU ; Jin WU ; Liangdan TANG
Journal of Third Military Medical University 2003;0(23):-
Objective To analyze the distribution of human papillomavirus (HPV) genotype in the diseases associated with HPV infection and explore the role of HPV genotype in these diseases. Methods Retrospective analysis was carried out to compare HPV genotypes of 353 outpatients suffering the diseases associated with HPV infection including cervical caner,cervical intraepithelial neoplasia (CIN),genital duc condyloma,and subclinical cervical human papillomavirus infection (SPI) in our department from January to October 2008. HybriMax were used to detect HPV genotype. The distribution data of HPV genotype were statistically analyzed. Results Totally 176 HPV positive females were found with a positive rate of 49.86%. HPV positive rate in cervical cancer was 100%,and all of them were high risk HPV. The positive rate was increased with the severity of CIN,and the higher histological-grade was,the higher HPV positive rate was (P
2.Estimation of evoked potentials based on MD criterion and Givens matrix in non-Gaussian noise environments.
Daifeng ZHA ; Yubao GAO ; Meiying XIONG ; Liangdan WU ; Tianshuang QIU
Journal of Biomedical Engineering 2010;27(3):495-499
Traditional EP analysis is developed under the condition that the background noises in EP are Gaussian distributed. Alpha stable distribution, a generalization of Gaussian, is better for modeling impulsive noises than Gaussian distribution in biomedical signal processing. Conventional blind separation and estimation method of evoked potentials is based on second order statistics (SOS). In this paper, we propose a new algorithm based on minimum dispersion criterion and Givens matrix. The simulation experiments show that the proposed new algorithm is more robust than the conventional algorithm.
Algorithms
;
Artifacts
;
Brain
;
physiology
;
Electroencephalography
;
methods
;
Evoked Potentials
;
physiology
;
Humans
;
Normal Distribution
;
Signal Processing, Computer-Assisted
3.Novel Mutation of the NCSTN Gene Identified in a Chinese Acne Inversa Family
Jing WU ; Huiyao GE ; Yiming FAN ; Qi ZHEN ; Lili TANG ; Liangdan SUN
Annals of Dermatology 2020;32(3):237-242
Acne inversa is a chronic inflammatory follicular disease with autosomal dominant inheritance. In recent years, many functional mutations in the NCSTN genes have been identified as the cause of familial acne inversa. Herein, we recruited four patients and seven unaffected individuals from a Chinese family and performed Sanger sequencing of the NCSTN gene. One novel frameshift mutation, c.450_459del (p.Ser 151GlnfsX48), was identified in exon 5 of the NCSTN gene. Three normal-looking children carrying the mutation were proven to be patients. We also presented a literature review from previous studies of acne inversa, suggesting that NCSTN is a hotspot gene for acne inversa. Most affected individuals experienced onset in adolescence. We confirmed the diagnosis in this family based on the mutation. This finding will help expound the relationship between the NCSTN gene and the pathogenesis of acne inversa and emphasize the value of genetic diagnosis in monogenic disorder.
4.Efficacy and safety of low-dose levonorgestrel-releasing intrauterine system in Chinese women: a multicenter, single-arm, open labeled interventional trial
Cuifeng QIAN ; Guangsheng FAN ; Qinping LIAO ; Shuying WU ; Duanduan LA ; Wen DI ; Baihua DONG ; Hongwei LIU ; Liangdan TANG ; Zheng'ai XIONG ; Hanwang ZHANG ; Yali HU ; Naiming YANG ; Mulan REN ; Hong SHI ; Gaopi DENG ; Zirong HUANG
Chinese Journal of Obstetrics and Gynecology 2018;53(6):409-413
Objective To evaluate the efficacy,bleeding profile and safety of low-dose levonorgestrel-releasing intrauterine system (LNG-IUS 8) in Chinese healthy women of childbearing age.Methods A multi-center,open-label,single-arm clinical trial conducted at 16 centres in China enrolled 773 healthy women of childbearing age (mean age 31.6 years old,range 18 to 40 years old),who demanded contraception,from April 2006 to June 2013.All women placed LNG-IUS 8 for 3 years and then been followed up at 3,6,9,12,18,24,30,36 months.The efficacy variables including pregnancy rate and expulsion rate were analyzed using life table,while observing adverse events (AE) to evaluate the safety.The bleeding profile happened during the study was assessed using 90-day reference intervals (World Health Organization criteria).Results Eight pregnancies occurred among 773 women,resulting in a overall Pearl index of 0.42 per 100 women years.The 3-year cumulative pregnancy rate was 0.37 per 100 women years and the 3-year cumulative expulsion rate was 1.99 per 100 women years.The number of women with bleeding/spotting reduced and the bleeding/spotting days declined over time.Totally 219 AE were reported related to LNG-IUS 8 placements.The most common AE were vaginal bleeding (8.2%,63/773)and the ovarian cyst (6.2%,52/773).LNG-IUS 8 had an improving effect on dysmenorrhea that the percentage of women with dysmenorrhea as well as the days of dysmenorrhea decreased over time.The percentage of women satisfied or very satisfied with LNG-IUS 8 was 87.2% (622/713).Conclusion LNG-IUS 8 is highly effective and safe for Chinese healthy women of childbearing age.