2.Blastic plasmacytoid dendritic cell neoplasm: report of a case.
Chinese Journal of Pathology 2011;40(10):710-711
Aged
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Antineoplastic Combined Chemotherapy Protocols
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therapeutic use
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CD4 Antigens
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metabolism
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CD56 Antigen
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metabolism
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Cyclophosphamide
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therapeutic use
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Dendritic Cells
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pathology
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Diagnosis, Differential
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Doxorubicin
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therapeutic use
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Female
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Humans
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Leukemia, Myeloid
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metabolism
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pathology
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Lymphoma, Extranodal NK-T-Cell
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metabolism
;
pathology
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Plasmacytoma
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drug therapy
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metabolism
;
pathology
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Precursor Cell Lymphoblastic Leukemia-Lymphoma
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metabolism
;
pathology
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Prednisone
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therapeutic use
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Skin Neoplasms
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drug therapy
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metabolism
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pathology
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Vincristine
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therapeutic use
3.Research on progress and prospect of kinase S6K1.
Hui ZHANG ; Junyu LIANG ; Ji ZHANG
Journal of Biomedical Engineering 2014;31(4):935-949
Obesity is a prevalent metabolic disorder, which seriously affects human health and has become the world's public health problem. Kinase S6K1, an important downstream effector of mammalian target of rapamycin (mTOR), influences specific pathological responses, including obesity, type 2 diabetes and cancer. Presently, S6K1 has become an attractive therapeutic target in the treatment of these disorders. Here, the functions of kinase S6K1, its molecular regulation mechanisms, related pathogenesis of disease and relevant small molecular inhibitors are reviewed. Finally, the prospect of research toward S6K1 is expected as well.
Animals
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Diabetes Mellitus, Type 2
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Humans
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Neoplasms
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Obesity
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Ribosomal Protein S6 Kinases, 70-kDa
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metabolism
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Signal Transduction
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TOR Serine-Threonine Kinases
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metabolism
4.Observation on the effect of Omeprazole combined with operation on treatment of rupture of small intestine in closed abdominal injury
Jiyan LIU ; Yuanxiao LIANG ; Hui ZHANG
Chinese Journal of Biochemical Pharmaceutics 2017;37(4):343-344
Objective To explore the the effect of Omeprazole combined with operation on treatment of rupture of small intestine in closed abdominal injury.Methods From June 2014 to December 2014,64 cases in Xinchang county people's hospitalwith rupture of small intestine in closed abdominal were divided into the treatment group and the control group,32 cases in each group.The control group were treat with surgery,the treatment group were given surgery combined with Omeprazole.The total effective rate,quality of life,the recovery time of bowel sound and the echaust time in the two groups were compared.Results The total effective rate(90.6%,29/32)in the treatment group was significantly higher than that in thecontrol group(75.0%,24/32),the difference is significant(P< 0.05).The life index in the treatment group is significantly better than that in the control group(P<0.05).The recovery time of bowel sound in the treatment group(15.3±2.6)h,is shorter than that in the control group(23.8±6.8)h; the exhaust time(23.6±2.2)h in the treatment group is lower than that in the control group(32.3±4.6)h,the differencesis statistically significant(P< 0.05).Conclusion It can significantly improve the effect and postoperative indexes which omeprazole combined with surgical treatment on the treatment of rupture of small intestine in closed abdominal injury,Itshould be widely promoted.
5.Clinical study on 30 cases of advanced lung adenocarcinoma treated with TCM treatment based on syndrome differentiation combined with Gefitinib
Hui LIANG ; Yunqi WANG ; Yuming LI ; Qiong ZHOU ; Hui ZHANG
International Journal of Traditional Chinese Medicine 2012;34(6):502-505
ObjectiveTo investigate the therapeutic effects of advanced lung adenocarcinoma treated with TCM treatment based on syndrome differentiation combined with Gefitinib.MethodsAll cases were recruited from adenocarcinoma of lung patients in Hunan Province Cancer Hospital from February 2008 to February 2010.These 56 adenocarcinoma of lung patients were randomly divided into a treatment group (30cases) and a control group (26 cases).The control group was treated with Gefitinib,250 mg/d,until the disease getting progress or the patient showing intolerable untoward reaction; while the treatment group was treated with TCM syndrome differentiation based on the control group.ResultsAfter the treatment,the total therapeutic effects was 90.00% in the treatment group than 65.38% in the control group (x2=5.40,P<0.05); symptoms score in both group decreased after the treatment,comparing with the same group before the treatment,with the difference was statistical significance (tthe treatment group=9.2446,tthe control group=2.7778,both P<0.01) ;non-progressive survival rate of half year,1year and 2year was 66.67%,50.00% and 30.00% respectively,and survival rate of lyear and 2yenr was 73.33% and 46.67% respectively,in the treatment group,while non-progressive survival rate of half year,lyear and 2year was 38.46%,23.08% and 7.69% respectively,and survival rate of 1year and 2year was 46.15% and 19.23% respectively,in the control group,showing statistical difference between the two groups (x2 value was 4.46、4.31、5.44、4.31、5.27,P value was 0.03、0.04、0.02、0.04、0.02,all P<0.05 ) ; the effective power of KPS was 76.67% and 46.15% in the treatment and the control group respectively,showing statistical difference(x2=6.24,P<0.05) ; both groups were absent of such side effects of hematology,heart,liver and kidney toxicity,and interstitial pneumonia,but the incidence rate of Ⅱ ~ Ⅲ degree rash and diarrhea was significantly decreased in the treatment group,comparing with the control group(x2=4.49、4.37,P<0.05 ).ConclusionThe therapy of TCM treatment based on syndrome differentiation combined with Gefitinib can improve living quality,control aggravation of disease,prolong life span and enhance survival rate of the patients with advanced lung adenocarcinoma.
6.piggyBac transposon system and its applications in the genemanipulation in mammals
Qianqian WANG ; Hui ZHANG ; Liang XIAO ; Liming ZHANG
Chinese Journal of Biochemical Pharmaceutics 2017;37(1):302-305
DNA transposon is a kind of factor that is able to translocate gene in its genome, thus offering an efficient method for permanently modifying the genome of mammals. The piggyBac (PB) transposon system has been proven effective in mammalian genomic engineering, including cancer gene discovery, animal transgenesis, in vivo gene delivery as well as in vitro genetic modification like induced pluripotent stem cells. In addition, piggyBac has many desirable features, such as seamless excision of transposons from the genomic DNA and the potential to target integration events to desired DNA sequences. Therefore, the piggyBac translocation system is an ideal genetic tool in the construction of animal models and gene therapy, and we can anticipate that the piggyBac transposon system will play a more and more important role in biomedical research.
7.Reliability and validity of the Chinese Version of the Personal Diabetes Questionnaire(PDQ)
Hui ZHANG ; Wei ZHENG ; Yufang ZHANG ; Zhimei LIU ; Dan LIANG
Chinese Journal of Practical Nursing 2014;30(29):50-53
Objective To translate the Personal Diabetes Questionnaire(PDQ),and test the relia bility and validity of the Chinese version of PDQ.Methods Through forward translation,back translation,cultural adjustment,etc.,the Personal Diabetes Questionnaire (PDQ) was introduced to localize it.60 eligible patients with diabetes were selected in a tertiary hospital to make a preliminary investigation.The results were statistically analyzed in order to assess the reliability and validity of the Chinese version of PDQ.Results The Chinese version of PDQ had good reliability,whose total internal consistency coefficient was 0.831 and test-retest reliability was 0.801.The questionnaire has good validity.Total Content Validity Index was 0.938.I-CVI was between 0.800 and 1.000.The questionnaire's dimensions had good parallel validity with glycosylated hemoglobin (HbAlc) and body mass index (BMI).Conclusions The Chinese Version of the personal diabetes questionnaire has good reliability and validity,which can be widely used as the evaluation tool of diabetes self-management education.
8.Progress on the characteristics of gene variants in sporadic medullary thyroid cancer
Han ZHANG ; Daqi ZHANG ; Nan LIANG ; Hui SUN
Chinese Journal of Endocrine Surgery 2021;15(2):205-207
Medullary thyroid carcinoma (MTC) is a rare endocrine tumor characterized by high malignancy, early metastasis and easy recurrence. Sporadic medullary thyroid carcinoma (sMTC) is the main pathological type of MTC, accounting for about 75%. Compared with hMTC which has more clear germline mutations in the RET gene, the pathogenesis of sMTC is still unclear. We mainly retrospectively reviewed the characteristics of gene variants and the associations of their gene variants with tumor risk, including RET gene variants, somatic RAS gene variants, CDKN gene variants and other gene variants, aiming to provide novel directions for the evaluation of patients in terms of etiology.
9.The study of miR-216a induces cell apoptosis by targeting PKCαin gastric cancer
Xuemei ZHANG ; Hui LAN ; Fang LIU ; Min DENG ; Xiaoqiu LIANG
Chongqing Medicine 2013;(33):4051-4052,4055
Objective To confirm whether miR-216a suppresses cell proliferation and induces cell apoptosis by targeting PKCα, thus to reveal molecular mechanism that miR-216a functions as a tumor suppressor in gastric cancer .Methods PKCα3′untranslat-ed region(UTR)-luciferase vector was constructed and dual-luciferase reporter gene assay was employed to examine the effect of miR-216a on luciferase activity .MGC-803 cells were transfected with miR-216a mimics ,and next Western blotting was performed to detect the expression of PKCαprotein .The effects of PKCαdownregulation on cell proliferation and apoptosis were observed after PKCαsiRNA were transfected into MGC-803 cells .MGC-803 cell proliferation assays were performed when cotransfected with miR-216a mimics .Results The result demonstrated miR-216a could bind to the 3′UTR of PKCαand inhibited the luciferase activi-ty ,cut the 41% .PKCαprotein expressions were significantly down-regulated when miR-216a was overexpressed in MGC-803 .siR-NA-mediated downregulation of PKCα could suppress the potentials of cell proliferation and induce apoptosis .Conclusion miR-216a suppresses cell proliferation and induces apoptosis by targeting PKCαmRNA 3′UTR in gastric cancer .
10.Surgical treatment of Marfan syndrome of pregnancy complicated with acute type A aortic dissection
Hui WANG ; Yong ZHANG ; Jiali LIANG ; Ming CHEN
Chinese Journal of Postgraduates of Medicine 2014;37(32):33-35
Objective To summarize the experience in the treatment of Marfan syndrome of pregnancy complicated with acute type A aortic dissection.Methods Three women with Marfan syndrome of pregnancy complicated with acute type A aortic dissection were treated.The average age was 28.6 (25-31) years,and the average gestational age was 36.5 (32-38) weeks.At first caesarean operation were performed under general anesthesia.Bentall + Sun' s operation was performed under deep hypothermic circulatory.After operation,the mother and fetus were followed up.Results Three women and their fetus were safe.The average extracorporeal circulation time,aorta clamp time and circulatory arrest time were 265 (210-280) min,135 (120-160) min and 26.5 (20-29) min,respectively.After a mean follow-up of 2.0 (1.0-2.5) years,3 patients were living well.CT angiogram detected normal aortic,with no signs of distal dilation.Three fetus were normal in development and neurocognitive function.Conclusion Methods of surgical repair and fetal delivery should be chosen based on aortic pathological changes and gestational age to maximize the safety of the mother and fetus.