With the rapid development of modern medicine and pharmacy, the diagnosis and treatment of cancer have made great progress.However, cancer treatment is still a difficult and urgent problem in clinic, because the early detection is difficult for many tumors, the toxic and side effects are serious for drug therapy and treatment effect is poor.Long circulating liposomes delivery system based on nano-medicine are used for the diagnosis and treatment of tumors, which have brought new hope to cancer patients.After administration, long circulating liposomes are known for prolonging the circulation time, increasing the targeting accumulation in tumor, improving the effects of diagnosis and treatment and reducing the toxic and side effects of loading medicine or probe.In this paper, the advantages of long circulating liposome delivery system loaded with diagnostic probe or antitumor agent in targeting diagnosis and treatment of tumor are reviewed.

OBJECTIVE:To discuss the role of clinical pharmacist in clinical drug treatment team.METHODS:The role of clinical pharmacist was discussed based on personal working experience in intensive care unit(ICU).RESULTS&CONCLU-SION:Clinical pharmacist is a learner,a helper and a communicator in the clinical drug treatment team.

Objective:To make the quality of STF detection based on traceability management process realize automation, thereby reducing the error evaluation lead to artificial visual error, impartiality and improve the reliability of quality traceability system.Methods: Using image acquisition system, the introduction of computer vision technique in STF cleanliness testing process, so the evaluation results of cleanliness for STF automation, reduce the artificial dependence, improve the fairness and reliability.Results: compared with the previous manual evaluation method to inspect based, automatic generation of test results, more efficient, more accurate.Conclusion: Using the visual processing technology in STF inspection, can reduce the lead toartificial inspection subjective miscarriage of justice, fairness and improve the reliability of the detection conclusion.

Objective: Through the introduction of the application background of ATP bioluminescence detection system, the technical principle and the factors of ATP bioluminescence detection system should be taken into account in the procurement, prompted the personnel understand the necessity of ATP bioluminescence detection system using, help procurement staffs purchasing suitable ATP bioluminescence detection system. Methods: introduces the application of ATP bioluminescence detection system background, technical principle and ATP bioluminescence detection system detection accuracy related factors, and gives reasonable purchase suggestions. Results:Improved procurement staffs’ understand to ATP bioluminescence detection system. Conclusion:ATP bioluminescence detection system as a new kind of detection system, with high sensitivity, simple and quick operation, become auxiliary tool of the various departments to conduct self-detection, hospital infection management department to check, understand the principle of technology of ATP bioluminescence detection system and ATP bioluminescence detection system detection accuracy related factors to help procurement staffs purchase the most suitable ATP bioluminescence detection system for clinical.

Objective To investigate the relationship between allergic rhinitis (AR), non-allergic rhinitis (NAR) and obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods Forty-eight patients with AR symptoms and snoring symptoms for at least 2 years, who received treatment in our outpatient, were included in this study. Skin prick test, serum specific IgE, polysomnography (PSG), acoustic rhinometry, nasal resistance (RM), Müller's test (FPMM) and Epworth sleepi?ness scale (ESS) were performed in patients. Results There were 25 AR patients (AR group) and 23 NAR cases (NAR group). ESS>9 scores were found in 19 patients, including 15 NAR cases and 4 AR cases. There was higher incidence of drowsiness in NAR group than that of AR group (P<0.05). Results of PSG showed that there were significantly higher proportions of apnea, poor sleep quality, AHI index, and lower values of the lowest oxygen saturation (LSpO2) and mean oxygen saturation (ASpO2) in NAR group than those of AR group (P<0.05). The incidence of OSAHS was significantly higher in NAR group than that of AR group (82.6%vs 36.0%, P<0.05). Conclusion Both AR and NAR were risk factors for OSAHS, and both can induce sleep disorders. NAR patients were more likely to result in OSAHS, and showing higher disease severity. NAR may have an important role in the initiation of OSAHS.

Objective To investigate the diagnostic value of D‐D and coagulation indices detection in cerebral apoplexy to provide the diagnostic basis for clinic .Methods Sixty patients with cerebral apoplexy in our hospital were selected and divided into the is‐chemic cerebral apoplexy group(observation group 1 ,40 cases) and hemorrhagic cerebral apoplexy group(observation group 2 ,20 cases) ,at the same time 60 individuals undergoing the physical examination in our hospital were selected as the control group .The blood coagulation instrument was adopted to detect D‐D ,PT ,APTT ,FIB and AT‐Ⅲ .Results Compared with the control group , the D‐D and FIB levels in the observation group 1 and 2 were obviously increased ,APTT was obviously extended and the AT‐Ⅲlevel was obviously reduced ,the differences between them had statistical significance(P<0 .05);the detection indices had no statis‐tical differences between the observation group 1 and 2(P>0 .05) .D‐D ,APTT and FIB were positively correlated with cerebral ap‐oplexy(r=0 .422 ,0 .138 ,0 .171 ,P<0 .05) .Conclusion The detection of D‐D ,APTT and FIB has the diagnostic value in diagno‐sing cerebral apoplexy ,especially the clinical significance of D‐D is more significant .

AIM: To observe the effect of curcumin on the retinal structure and the expressions of interleukin-23 (IL-23) and interleukin-17(IL-17) in the rat retina after retinal ischemia-reperfusion injury (RIRI).METHODS:A total of 60 male Sprague-Dawley(SD) rats were randomly divided into normal control group(NCG),model group(MG),low-dose curcumin group (LDCG) and high-dose curcumin group (HDCG) (n=15 per group).RIRI was generated by anterior chamber perfusion of normal saline to the right eye.Rats in LDCG and HDCG received an intraperitoneal injection of 20mg/kg/d and 100mg/kg/d curcumin respectively,at 30min before RIRI and once daily after RIRI.Retinal structure and inflammation were evaluated after hematoxylin and eosin-stained (HE) staining.Western-blot and enzyme-linked immunosorbent assay (ELISA) were used to measure the level of IL-23 and IL-17 expressions after RIRI.RESULTS: The retinal structure of NCG was normal.Retinal edema,empty spaces or loosely packed cells and inflammatory cell infiltration were observed in MG and LDCG groups,whereas the morphological changes in HDCG group were improved as compared to MG and LDCG groups.Western-blot assay and ELISA showed that IL-23 and IL-17 expressions increased significantly after RIRI (vs NCG,P<0.01).Moreover,curcumin reduced IL-23 and IL-17 expressions significantly (vs MG,P<0.01).CONCLUSION: Curcumin can inhibit leukocytes infiltration and improve the retinal pathologic changes.Furthermore,curcumin can reduce retinal IL-23 and IL-17 expressions significantly in a dose-dependent manner.

Melatonin (N-acetyl-5-methoxytryptamine, MT) is a hormone synthesized and secreted by the pineal gland. Recent studies show that melatonin plays an essential role in the pathogenesis of many reproductive processes. High-concentration melatonin exists in human preovulatory follicular fluid and melatonin receptors are present in ovarian granulosa cells, which indicates the direct effects of melatonin on ovarian function. Reactive oxygen species are involved in a number of reproductive events, including folliculogenesis, follicular atresia, ovulation, oocyte maturation, and corpus luteum formation. Melatonin and its metabolites, as powerful antioxidants and free radical scavengers, can potentially inhibit premature ovarian failure. Literature published in recent years shows the essential roles of melatonin in improving human ovarian function and oocyte quality as well as in the management of infertility. Researches on the action mechanisms of melatonin may provide a theoretical basis for the prevention and treatment of some clinical diseases.
Female ; Granulosa Cells ; metabolism ; physiology ; Humans ; Melatonin ; metabolism ; physiology ; Ovarian Follicle ; growth & development ; metabolism ; Ovary ; physiology ; Reactive Oxygen Species ; metabolism

Objective To observe the influences of different analgesic methods on blood sugar, stress hormones and cytokinesMethods According to different postoperative analgesic methods, 30 patients immediately after elective cholecystectomy, were randomly divided into four groups: normal saline was infused epidurally in group C as control; analgesia via epidural infusion of morphine 2 mg in group EM; patient-controlled analgesia via epidural or intravenous fentanyl in group PCEFA or group PCIFABlood sugar, cortisol, insulin, interlukin-2 (IL-2), interlukin-6 (IL-6) and tumor necrosis factor-?(TNF-?) levels were determined during the perioperative periodResults Postoperative visual analog score was higher in group C than that in group EM, group PCEFA or group PCIFA (P005)Conclusions Postoperative application of PCEFA can much more help to maintain the stability of neuroimmunoendocrinal system

Choroidal thickness and its relevance with retinal disease has been widely studied in recent years,as choroid is an important source of retina blood supply.Diabetic retinopathy (DR) studies have been focused on retinal vascular injury and related circulatory disorders for a long time,however recent studies have found that choroidal blood vessels are also affected by diabetes,including the thickness changes.The choroidal thickness of diabetic patients is thinner than normal.There is no conclusive conclusion about choroidal thickness and the severity of DR lesions,as the choroid thickness results are determined by multiple factors,including diseases,ocular conditions (choroidal vascular status,ocular axial length,refractory errors and other eye parameters),systemic factors (age and sex) and measurement methods.Therefore,it is necessary to calibrate the ocular and extra-ocular factors affecting choroidal thickness when trying to further clarify the relationship between the choroidal thickness and DR.