1.The role of intrauterine growth retardation on postnatal lipid metabolism and its mechanism
International Journal of Pediatrics 2014;(4):347-350
Intrauterine growth retardation( IUGR) is a common complication during pregnancy. Epide-miological and clinical studies have shown that IUGR has a long-term impact on postnatal lipid metabolism. The effect of IUGR on postnatal lipid metabolism is accomplished by regulating signal pathways of fatty acid and cholesterol metabolism,which may be mediated by epigenetic modifications. Further study of these epigenetic mechanisms could lead to a novel way for prevention and treatment of adulthood diseases, including dyslipi-demia,non-alcoholic fatty liver disease and metabolic syndrome.
2.Analysis of therapeutic efficacy in 49 patients with advanced non-small cell cancer treated with gefitinib.
Chinese Journal of Oncology 2007;29(8):635-636
Adult
;
Aged
;
Aged, 80 and over
;
Antineoplastic Agents
;
adverse effects
;
therapeutic use
;
Brain Neoplasms
;
secondary
;
Carcinoma, Non-Small-Cell Lung
;
drug therapy
;
secondary
;
Exanthema
;
chemically induced
;
Female
;
Humans
;
Liver Neoplasms
;
secondary
;
Lung Neoplasms
;
drug therapy
;
pathology
;
Male
;
Middle Aged
;
Neoplasm Staging
;
Protein Kinase Inhibitors
;
adverse effects
;
therapeutic use
;
Quinazolines
;
adverse effects
;
therapeutic use
;
Remission Induction
;
Survival Rate
;
Vomiting
;
chemically induced
3.56 Cases with Low Frequency Sensorineural Hearing Loss:Assessment and Analysis
Fude LI ; Ruimin LIANG ; Chen CHEN
Journal of Audiology and Speech Pathology 1998;0(01):-
Objective The diagnosis of low frequency sensorineural hearing loss is examined for clinical applications.Methods Pure tone threshold (PTT),acoustic impedance,auditory brainstem response(ABR),distortion product otoacoustic emissions(DPOAE),electrocochleogram(ECochG) and imaging examinations of CT or MRI were performed on 56 cases with low frequency sensorineural hearing loss.Results Among 56 cases of low frequency sensorineural hearing loss,38 cases with sudden low frequency sensorineural hearing loss,9 with Meniere's disease,6 as auditory neuropathy,1 case of acoustic neuroma,1 case of multiple sclerosis and 1 case with arachnoid cyst of cerebellar hemisphere surface.Conclusion Low frequency sensorineural hearing losses occurred in varied diseases.A comprehensive approach should be taken to diagnose this hearing loss and if necessary,CT or MRI can be utilized to confirm the standard audiologic evaluations.
4.56 Cases with Low Frequency Sensorineural Hearing Loss: Assessment and Analysis
Fude LI ; Ruimin LIANG ; Chen CHEN
Journal of Audiology and Speech Pathology 2010;18(1):19-22
Objective The diagnosis of low frequency sensorineural hearing loss is examined for clinical applications.Methods Pure tone threshold(PTT),acoustic impedance,auditory brainstem response(ABR),distortion product otoacoustic emissions(DPOAE),electrocochleogram(ECochG)and imaging examinations of CT or MRI were performed on 56 cases with low frequency sensorineural hearing loss.Results Among 56 cases of low frequency sensorineural hearing loss,38 cases with sudden low frequency sensorineural hearing loss,9 with Meniere's disease, 6 as auditory neuropathy,1 case of acoustic neuroma,1 case of multiple sclerosis and 1 case with arachnoid cyst of cerebellar hemisphere surface.Conclusion Low frequency sensorineural hearing losses occurred in varied diseases.A comprehensive approach should be taken to diagnose this hearing loss and if necessary,CT or MRI can be utilized to confirm the standard audiologic evaluations.
5.Astrocyte Proliferation and Glial Scar Formation after Spinal Cord Injury (review)
Liang WU ; Jianjun LI ; Liang CHEN ; Li YUAN ; Xiaolei LU
Chinese Journal of Rehabilitation Theory and Practice 2010;16(3):201-204
The nature and functions of astrocytes (AS), the pathological changes and roles of AS after spinal cord injury, the experimental methods of inhibiting AS proliferation and glial scar formation, and so on, were reviewed. AS beneficially affects repairing injured spinal cord at different periods of differentiation. However, adult AS secreting the factors formed the chemical glial barrier which severely affects nerve regeneration and hinders axon extension. Because of the static, activated and proliferative AS tending to coexist after spinal cord injury, and complex factors of barrier formation, the current approach taken by a single method is difficult to effectively control the AS proliferation and glial scar formation.
6.Primary culture and identification of human placental microvascular endothelial cell in vitro
Li CHEN ; Zhiqing LIANG ; Junnan LI
Journal of Third Military Medical University 2003;0(09):-
Objective To explore the methods of culture and identification of human placental microvascular endothelial cells(HPMVEC) in vitro,aiming to construct the polar model of human placental barrier.Methods By proteolytic enzymes,the tissular and cellular suspensions were collected from the chorionic villi of pregnant and centrifugated over a preformed discontinuous Percoll gradient.The highly purified human placental microvascular endothelial cells were obtained and cultured in HG-DMEM with fetal calf serum and identified by immunocytochemistry(SP methods) and transmission electron microscope.Results The highly purified human microvascular endothelial cells were cultured in vitro and passaged for three to five generations.Factor Ⅷ-related antigen and CD34 were both positive by immunocytochemistry.Weibel-Palade body(W-P body) was observed by transmission electron microscope.Conclusion Human placental microvascular endothelial cells can be isolated and cultured successfully in vitro by our method.
7.Treatment for lumbar disc herniation with percutaneous transforaminal endoscopic discectomy and discussing the relative problems
Liang CHENG ; Jian KANG ; Weixing LI ; Fang LIANG ; Haibin CHEN
International Journal of Surgery 2015;42(2):93-96,封3
Objective To investigate the efficiency,decision of intra-operative puncture route,treatment of perioperative complications and discuss the other relative problems of the treament for lumbar disc herniation with percutaneous transforaminal endoscopic discectomy.Methods To excise the nucleus pulpesus under percutaneous transforaminal endoscopic discectomy,use the Macnab standard,visual analogue scale and infrared thermal imaging to estimate the efficiency.Results Among followed-up of 208 patients,182 patients were excellent and good outcome,23 patients favorable,2 patients fair,0 patient poor.The leg and back VAS was a significant improvement 1 week post-operation compared with pre-operation (P < 0.05),but no statistical difference among 3 months,6 months,12 months and 1 week post-operation (P > 0.05).The infrared thermal imaging point out that the legs skin temperature of D-value was a significant improvement post-operation compared with pre-operation (P < 0.05).Conclusions The method excised the nucleus pulpesus,and provided the spine maximum protection about the stability and flexibility.Intra-operative puncture route of individuation design can reduce the complications of intervertebral foramen perioperative,and the key to improve the effectiveness.
8.The effects of personality and self-consciousness on the orthodontic compliance of adolescents
Yong CHEN ; Jiaxing LIANG ; Li LIN
Journal of Practical Stomatology 2001;0(01):-
Objective: To study the effects of psychological variables on orthodontic compliance of adolescents.Methods:Prior to orthodontic treatment,60 adolescent patients received two questionnaires for the analysis of their personality(EPQ) and self-consciousness.The compliance of the patients was evaluated at each visit and 6 months after the beginning of treatment by orthodontists.Results:The outgoing personality and the high self-consciousness significantly predicted good orthodontic compliance of the adolescent patients in the treatment(P
9.Analysis of Clinical Findings and Audioloical Result of Auditory Neuropathy
Fude LI ; Jiaping CHEN ; Ruimin LIANG
Journal of Audiology and Speech Pathology 1998;0(03):-
Objective To study the clinical findings and audiological characteristics of auditory neuropathy. Methods Clinical findings, pure tone threshold, acoustic impedance audiometry, speech audiometry, auditory brainstem response (ABR) and distortion product otoacoustic emission( DPOAE) were analyzed in 23 cases of auditory neuropathy. Results The patients were predominantly youngster, female more than male. Pure tone audiometry revealed mainly binaural symmetric upward - sloping audiogram with mild and moderate hearing loss at low frequencies. Speech discrimination score was obviously reduced, which was disproportionately to the pure tone threshold. Ipsilateral and contralateral stapedial reflex were absent. ABR was severely abnor- mal. DPOAIE was normal or nearly normal. Conclusion Clinical findings and systemic audiometry revealed the main characteristics of auditory neuropathy, which could be used not only for the understanding, but also for the diagnosis of this disease.
10.Analysis of Pure Tone Hearing Threshold of Auditory Neuropathy
Fude LI ; Jiaping CHEN ; Ruimin LIANG
Journal of Audiology and Speech Pathology 1997;0(04):-
Objective To explore the characte ristics of pure tone threshold (PTT) in auditory neuropathy. Methods The results of PTT audiometry were analysed in 48 patients with auditory neuropathy and compared with that of cochlear deafness. Results PTT audiograms in auditory neuropathy group r evealed curves including ascending slope, peak, spoon, letter W, lain letter S, flat, gentle slope. Binaural symmetric PTT audiograms were seen in 38 cases and asymmetric in 10 cases. The auditory threshold in auditory neuropathy showed a e levated range from mild to moderate degrees. Elevated degrees of auditory thresh old in left and right ears were consistent. The elevations of low-frequency audi tory threshold or in the main feature of low-frequency auditory threshold were 9 3.75% (90/96 ears) in the PTT audiograms. Conclusion The elevations of biauricular symmetric and ba sic symmetric low-frequency auditory threshold or in the main feature of low-fre quency auditory threshold were important characteristics of auditory neuropathy.